A5100449823- MicroRNA in disease regulation
- Plant-Microbe Interactions and Immunity
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Plant Pathogenic Bacteria Studies
- RNA and protein synthesis mechanisms
- Molecular Biology Techniques and Applications
- Bamboo properties and applications
- Gene expression and cancer classification
- Tree Root and Stability Studies
- Complexity and Algorithms in Graphs
- RNA modifications and cancer
- Genetically Modified Organisms Research
- Plant Disease Resistance and Genetics
- Network Security and Intrusion Detection
- CRISPR and Genetic Engineering
- Plant pathogens and resistance mechanisms
- Legume Nitrogen Fixing Symbiosis
- Natural Fiber Reinforced Composites
- Advanced Graph Theory Research
- Epigenetics and DNA Methylation
- Anomaly Detection Techniques and Applications
- Internet Traffic Analysis and Secure E-voting
- Food Supply Chain Traceability
- Optimization and Search Problems
Zhejiang Normal University
2018-2024
First Hospital of Jilin University
2018-2024
Jilin University
2018-2024
Fudan University
2024
Chongqing Institute of Green and Intelligent Technology
2022-2023
West China Hospital of Sichuan University
2021-2022
Sichuan University
2021-2022
Shanghai Ninth People's Hospital
2022
Shanghai Jiao Tong University
2022
Chinese Academy of Sciences
1995-2022
Bacterial blight (BB) is a globally devastating rice disease caused by Xanthomonas oryzae pv. (Xoo). The use of resistance (R) genes in breeding an effective and economical strategy for the control this disease. Nevertheless, majority R lack durable long-term under global warming conditions. Here, we report isolation novel executor gene, Xa7, that confers extremely durable, broad-spectrum, heat-tolerant to Xoo. expression Xa7 was induced incompatible Xoo strains secreted transcription...
Abstract Osteoarthritis (OA) is a degenerative joint disorder causing pain and functional disability. Emerging evidence reveals that circular RNAs (circRNAs) play essential roles in OA progression development. This study aimed to investigate the role of novel circRNA factor, circFOXO3, elucidate its underlying molecular mechanism. The function circFOXO3 interaction between downstream mRNA target, forkhead box O3 (FOXO3), were evaluated by western blot (WB), immunofluorescence (IF), RNA...
Osteoarthritis (OA) presents a significant therapeutic challenge, with few options for preserving joint cartilage and repairing associated tissue damage. Inflammation is pivotal factor in OA-induced deterioration synovial inflammation. Recently, exosomes derived from human umbilical cord mesenchymal stem cells (HucMSCs) have gained recognition as promising noncellular modality, but their use hindered by the challenge of harvesting sufficient number effective efficacy. Given that HucMSCs are...
Abstract Background Chronic obstructive pulmonary disease (COPD) is one of the world’s leading causes death and a major chronic disease, highly prevalent in aging population exposed to tobacco smoke airborne pollutants, which calls for early useful biomolecular predictors. Roles noncoding RNAs COPD have been proposed, however, not many studies systematically investigated crosstalk among various transcripts this context. The construction RNA functional networks such as lncRNA-mRNA,...
Background: T cell malignancies are highly aggressive hematological tumors with limited effective treatment options. CAR-NK therapy targeting CD7 has emerged as a promising approach for treating T-cell malignancies. However, conventional faces the challenges of fratricide due to expression on both malignant cells and normal NK cells. Additionally, engineering CARs into human tissue-derived demonstrates heterogeneity, low transduction efficiency, high manufacturing costs. Methods: The...
Bacterial blight (BB), caused by Xanthomonas oryzae pv. ( Xoo ), is a widespread and destructive disease in rice production. Previously, we cloned an executor R gene, Xa7 , which confers durable broad-spectrum resistance to BB. Here, further confirmed that the transcription activator-like effector (TALE) AvrXa7 strains could directly bind effector-binding element (EBE) promoter of gene. Other genes Xa10 Xa23 Xa27 ) driven gene be activated trigger hypersensitive response (HR) tobacco leaves....
Accumulating evidence has indicated that aberrant expression of long non-coding RNAs (lncRNAs) is an important oncogenic factor. The aim the present study was to investigate role LINC01296, lncRNA exerts a tumor‑promoting function in many cancers, regulation proliferation, metastasis and cell cycle osteosarcoma. LINC01296 osteosarcoma tissues adjacent healthy 30 patients analyzed by quantitative real‑time PCR (qRT‑PCR). relationship between survival with also explored. levels cells normal...
Currently, more and malicious insiders are making threats, the detection of insider threats is becoming challenging. The often uses legitimate access privileges mimic normal behaviors to evade detection, which difficult be detected via using traditional defensive solutions. In this paper, we propose DeepMIT, a threat framework, utilizes Recurrent Neural Network (RNN) model user as time sequences predict probabilities anomalies. This framework allows DeepMIT continue learning, detections made...
The need for bladder reconstruction and side effects of cystoplasty have spawned the demand development alternative material substitutes. Biomaterials such as submucosa small intestine (SIS) been widely used patches repair, but outcomes are not fully satisfactory. To capture stem cells in situ has considered a promising strategy to speed up process re-cellularization functionalization. In this study, we developed an anti-CD29 antibody-conjugated SIS scaffold (AC-SIS) which is capable...
MicroRNAs (miRNAs) are crucial player in plant-pathogen interaction. While the evidence has demonstrated that rice miRNAs mediate immune response to pathogens invasion, roles of on Xanthomonas oryzae pv. (Xoo) attack remain be place. Herein, we monitored responsive changes at 0, 8, 24 h across Xoo strain PXO86 infection its compatible variety IR24 and incompatible IRBB5 by small RNA sequencing, genes targeted were also detected via degradome technology. The faithfulness sequencing data was...
In the context of global sustainable development, use natural and renewable bamboo as a building material is great significance for engineering. As an important part bamboo, there still lack systematic research on effect nodes mechanical properties bamboo. this paper, compression parallel to grain bending, tensile grain, shear perpendicular tests entire culm P. edulis were carried out, effects moisture content, bearing capacity analyzed. The relationship between standardized parameters node...
Long non‑coding (lnc)RNA heart and neural crest derivatives expressed 2‑antisense RNA 1 (HAND2‑AS1), an lncRNA antisense transcript adjacent to the 2 protein (HAND2), inhibits development of several types cancer; however, its role in melanoma is currently unknown. In present study, it was revealed that HAND2‑AS1 downregulated, whereas Rho‑associated kinase (ROCK1) mRNA upregulated tumor tissues when compared with healthy patients melanoma. Expression levels ROCK1 were inversely correlated...
Salicylic acid (SA) is a key natural component that mediates local and systemic resistance to pathogens in many dicotyledonous species. However, its function controversial disease rice plants. Here, we show the SA signaling involved both pathogen-associated-molecular-patterns triggered immunity (PTI) effector (ETI) Xanthomonas oryzae pv. Oryzae (Xoo) mediated by recessive gene xa5, which OsNPR3.3 plays an important role through interacting with TGAL11. Rice plants containing homozygous xa5...
Abstract A hybrid global optimization algorithm using a combination of simulated annealing and downhill simplex methods is used to invert teleseismic body waves for earthquake source parameters. Time-domain constraints on the source-time function, inversion double-couple parameters rather than moment tensor elements, consideration multiple sources lead nonlinear multimodal problem, in which objective function contains many local minima. Traditional approaches that linearize problem use...
Abstract The xa5 gene encodes a basal transcription factor (TFIIAγ) protein with wide spectrum resistance to bacterial blight caused by Xanthomonas oryzae pv. Oryzae ( Xoo ) in rice. It was only found few rice ecotypes, and the recessive characteristics limited its application breeding. Here, we employed TALEN-based technique edit dominant allelic TFIIAγ5 obtained many mutant genes. Most of them reduced susceptibility varying degrees when plants were challenged . In particular, knocked-out...