Neuropathic pain is a chronic and severe syndrome for which effective therapy insufficient the release of ATP from microglia induced by sphingosine-1-phosphate (S1P) plays vital role in neuropathic pain. Therefore, there an urgent demand to develop highly sensitive selective biosensors quantitative monitoring low-concentration complex nervous system, helps understanding mechanism involved Herein, we developed electrochemical microsensor based on entropy-driven bipedal DNA walker. First,...

Abstract miR-374a-5p expression and localization in intracranial aneurysm (IA) tissues were detected, its correlation with vascular smooth muscle cells (VSMCs) macrophage markers was analyzed. Using platelet-derived growth factor-BB (PDGF-BB) induced VSMC model, elastase-induced IA rat model. Subsequently, knocked down or overexpressed. We investigated the effects of on phenotypic conversion, vivo experiments also carried out to verify findings. The targeted relationship between WNTA5 effect...

ABSTRACT The Yabrai range‐front fault (YRF) is a large‐scale within the Alashan Block, located northeast of Tibetan Plateau, which has undergone several surface rupture events on southwestern and middle segments since late Quaternary. As no relevant research been conducted northeastern segment, paleoseismic data for this area are lacking, restricts our overall understanding spatiotemporal intensity distribution strong earthquakes YRF. To address problem, we investigations based trench wall...

Cooperative control for virtual coupling systems of multiple heavy-haul trains can improve the safety and efficiency railway transportation. However, false data injection attack system is a serious obstacle, which will lead to imprecise train operation control. To address this issue, deep learning-based (FDIA) detection proposed. First, cyber-physical model established. Second, cooperative law designed system, effects FDIA on analyzed. Then, unsupervised autoencoder method introduced achieve...

In the context of global sustainable development, use natural and renewable bamboo as a building material is great significance for engineering. As an important part bamboo, there still lack systematic research on effect nodes mechanical properties bamboo. this paper, compression parallel to grain bending, tensile grain, shear perpendicular tests entire culm P. edulis were carried out, effects moisture content, bearing capacity analyzed. The relationship between standardized parameters node...

Hypertensive intracerebral hemorrhage (HICH) is a life-threatening disease and lacks effective treatments. Previous studies have confirmed that metabolic profiles altered after ischemic stroke, but how brain metabolism changes HICH was unclear. This study aimed to explore the therapeutic effects of soyasaponin I on HICH.HICH model established first. Hematoxylin eosin staining used estimate pathological HICH. Western blot Evans blue extravasation assay were applied determine integrity...

This paper presents a solution to address the challenges of unexpected events in operation metro trains, which can lead increased delays and safety risks. An improved Q-learning algorithm is proposed reschedule train timetables via incorporating detention different section running times as actions. To enhance computational efficiency convergence rate, simulated annealing dynamic factor introduced improve action selection strategies. Additionally, importance sampling employed evaluate...

The generation efficiency of electromagnetic acoustic transducers (EMATs) dramatically reduces with increasing lift-off, thus restricting their applications. This paper aims to provide methods decrease lift-off sensitivity. process generating a shear wave in spiral coil EMAT is established based on 2-D axisymmetric model using the finite element method. An equivalent excitation circuit, including an impedance-matching network and limited power source, presented for calculating current. Such...

In order to determine the design strengths of P. edulis bamboo material, this research carried out a series material tests on full-culm specimens, including compression parallel grain, bending tests, tension shear grain and perpendicular grain. The standard values different for were obtained by Bootstrap method. influence load combination effect ratio relationship between reliability index β resistance factor γR was analyzed. A method calculating target strength proposed. determined...

In this article, a kind of original bamboo-fiber reinforced phosphogypsum composite wall was proposed. The axial compression tests eight walls and finite element analysis were carried out. failure modes mechanical properties the explored, influence parameters on performance studied, calculation methods capacity stiffness results show that cracked first in during loading process, cracks gradually spreaded through widened, bamboo tubes inside crushed. buckling occurred pure wall. bearing...

Microelectrode- and nanoelectrode-based electrochemistry has become a powerful tool for the in situ monitoring of various biomolecules vivo. However, two challenges limit application micro- nanoelectrodes: difficulty highly sensitive detection nonelectroactive molecules specific target complex biological environments. Herein, we propose an electrochemical microsensor based on entropy-driven multipedal DNA walker selective ATP. An ATP aptamer was immobilized microelectrode surface to form...

SUMMARY The cumulative displacement by multiple slip events along faults may generate composite damage zones (CDZ) of increasing width, and could modify the hydraulic mechanical properties faults. internal architecture fracture distribution within CDZs at subsurface are analysed here using seismic attributes variance, curvature dip-azimuth 3-D reflection data from tight sandstone reservoirs in northeast Sichuan, China. intersect reservoir a depth range 2.4–3.0 km. intensity mapping revealed...

To improve the oxidation resistance of Mo-based alloys, a novel (Mo,Hf)Si2-Al2O3 composite coating was fabricated on alloy by method slurry sintering. The isothermal behavior evaluated at 1400 °C. microstructure evolution and phase composition before after exposure were characterized. anti-oxidant mechanism for good performance during high-temperature discussed. had double-layer structure consisting MoSi2 inner layer outer layer. could offer more than 40 h oxidation-resistant protection °C...

Heavy-haul transportation plays a significant role in railway freight. Limited by the complex topography and resource distribution, China's heavy-haul railways contain great number of long downward slopes, which is main challenge for combined trains. Constrained pneumatic brake system train, cyclic needs to be applied provide adequate braking capability, when train running on steep slope. The subject this work 20,000-tonne trains, consisting 1 locomotive +105 wagons + 105 with end device...