A5100350537- Extracellular vesicles in disease
- Advanced Photocatalysis Techniques
- Nanocluster Synthesis and Applications
- MicroRNA in disease regulation
- Osteoarthritis Treatment and Mechanisms
- Nanoplatforms for cancer theranostics
- CO2 Reduction Techniques and Catalysts
- Metal-Organic Frameworks: Synthesis and Applications
- Electrocatalysts for Energy Conversion
- Nanopore and Nanochannel Transport Studies
- Perovskite Materials and Applications
- Advanced biosensing and bioanalysis techniques
- Inflammasome and immune disorders
- Advanced battery technologies research
- Flavonoids in Medical Research
- Optimism, Hope, and Well-being
- Carbon and Quantum Dots Applications
- Optical measurement and interference techniques
- Circular RNAs in diseases
- Carbon Nanotubes in Composites
- Heme Oxygenase-1 and Carbon Monoxide
- Polymer Surface Interaction Studies
- Surface Roughness and Optical Measurements
- Protein Hydrolysis and Bioactive Peptides
- Web Data Mining and Analysis
Jinzhou Medical University
2024-2025
Lanzhou University
2024
University of Notre Dame
2024
Hunan Normal University
2024
Beijing Institute of Technology
2024
Fujian University of Traditional Chinese Medicine
2024
China Pharmaceutical University
2023
Institute of Biomedical Sciences, Academia Sinica
2023
Southwest University
2021-2023
Guangxi Medical University
2023
As chondrocytes from osteoarthritic cartilage usually exhibit aging and senescent characteristics, targeting could be a potential therapeutic strategy. In this study, exosomes derived umbilical cord-derived mesenchymal stem cells (UCMSC-EXOs) combined with the chondrocyte-targeting capacity controlled-release system were proposed for osteoarthritis (OA) treatment via rejuvenating chondrocytes. The essential functional miRNAs within UCMSC-EXOs investigated, p53 signaling pathway identified as...
Abstract Abnormal silencing of fibroblast growth factor (FGF) signaling significantly contributes to joint dysplasia and osteoarthritis (OA); However, the clinical translation FGF18‐based protein drugs is hindered by their short half‐life, low delivery efficiency need for repeated articular injections. This study proposes a CRISPR/Cas9‐based approach effectively activate FGF18 gene OA chondrocytes at genome level in vivo, using chondrocyte‐affinity peptide (CAP) incorporated hybrid exosomes...
Nature-inspired supramolecular self-assemblies are attractive photocatalysts, but their quantum yields limited by poor charge separation and transportation. A promising strategy for efficient transfer is to enhance the built-in electric field symmetry breaking. Herein, an unsymmetric protonation, N-heterocyclic π-conjugated anthrazoline-based photocatalyst SA-DADK-H
Emodin, the effective component of traditional Chinese medicine Dahuang, has anti-inflammatory effects. However, protective effects and potential mechanisms emodin are not clear. This study investigated on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in vitro vivo. In vivo, we designed an LPS-induced ALI rat model. vitro, chose J774A.1 cell line to establish inflammatory cellular model, knocked down NOD-like receptor family pyrin domain containing 3 (NLRP3) using small...
In this work, an original rolling-circle strand displacement amplification (RC-SDA) was developed by introducing a circle DNA with two recognition domains as template instead of the limited liner in traditional (SDA), which displayed much shorter reaction time down to 30 min and quite higher conversion efficiency more than 1.77 × 108 compared those (SDA) could be applied construct label-free biosensor for ultrasensitive detection HIV fragment. Once target fragment interacts DNA, RC-SDA...
Osteoarthritis (OA) presents a significant therapeutic challenge, with few options for preserving joint cartilage and repairing associated tissue damage. Inflammation is pivotal factor in OA-induced deterioration synovial inflammation. Recently, exosomes derived from human umbilical cord mesenchymal stem cells (HucMSCs) have gained recognition as promising noncellular modality, but their use hindered by the challenge of harvesting sufficient number effective efficacy. Given that HucMSCs are...
A novel fluorescence sensor based on molybdenum‐doped carbon quantum dots (Mo‐CQDs) was developed to determine lemon yellow in beverages. Mo‐CQDs were prepared from β‐cyclodextrin(carbon source) and ammonium molybdate through a bottom‐up, one‐step hydrothermal synthesis. The composition structure of determined using transmission electron microscopy, x‐ray energy spectrum analysis, FT‐IR. amount involved the reaction pH system optimized optimal conditions. quantitative standard curve...
Photocatalytic hydrogen peroxide (H2O2) production has emerged as an attractive alternative to the traditional anthraquinone process. However, its performance is often hindered by low selectivity and sluggish kinetics of oxygen reduction reaction (ORR). Herein, we report anthrazoline‐based supramolecular photocatalyst, SA‐SADF‐H+, featuring unsymmetric protonation structure for H2O2 photosynthesis from water air. The introduction disrupts initial mirror symmetry SADF, significantly enhancing...
Fly ash (FA) usually causes air and soil pollution due to wind erosion. However, most FA field surface stabilization technologies have long construction periods, poor curing effects, secondary pollution. Therefore, there is an urgent need develop efficient environmentally friendly technology. Polyacrylamide (PAM) environmental macromolecular chemical material for improvement, Enzyme Induced Carbonate Precipitation (EICP) a new bio-reinforced This study attempted use chemical, biological,...
Mitochondrial dysfunction in chondrocytes is a key pathogenic factor osteoarthritis (OA), but directly modulating mitochondria vivo remains significant challenge. This study the first to verify correlation between mitochondrial and downregulation of FOXO3 gene cartilage OA patients, highlighting potential for regulating mitophagy via modulation alleviate OA. Consequently, we developed chondrocyte-targeting CRISPR/Cas9-based gene-editing tool (FoxO3) integrated it within nanoengineered...
Here, we explored the influences of thyme microcapsules on growth, gene expression, and histamine accumulation by Proteus bacillus isolated from smoked horsemeat sausage. RT-qPCR was employed to evaluate expression level histidine decarboxylase (HDC) cascade-associated genes. We used HPLC monitor concentration both in pure culture as well processing Results showed that suppressed microcapsule inhibitory effect histamine-producing bacteria reduction transcription hdcA hdcP Besides, compared...
Aiming at the difficult problem of high-precision axicon profile measurement, a laser differential confocal normal tracking (LDCNT) measurement method with high spatial resolution and anti-tilt capability is proposed in this paper. The utilizes principle direction adaptive for measurement. It employs PSD image plane spot position to calculate angle rotary axis drive sensor measured surface achieve reduce difficulty pose adjustment axicon. Using focusing principle, signal normalized improve...
Abstract Nature‐inspired supramolecular self‐assemblies are attractive photocatalysts, but their quantum yields limited by poor charge separation and transportation. A promising strategy for efficient transfer is to enhance the built‐in electric field symmetry breaking. Herein, an unsymmetric protonation, N‐heterocyclic π‐conjugated anthrazoline‐based photocatalyst SA‐DADK‐H + was developed. The protonation breaks initial structural of DADK , resulting in ca. 50‐fold increase molecular...
Photocatalytic hydrogen peroxide (H2O2) production has emerged as an attractive alternative to the traditional anthraquinone process. However, its performance is often hindered by low selectivity and sluggish kinetics of oxygen reduction reaction (ORR). Herein, we report anthrazoline‐based supramolecular photocatalyst, SA‐SADF‐H+, featuring unsymmetric protonation structure for H2O2 photosynthesis from water air. The introduction disrupts initial mirror symmetry SADF, significantly enhancing...