A5101938733- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Multiple Myeloma Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- CAR-T cell therapy research
- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- Chronic Lymphocytic Leukemia Research
- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
- Circular RNAs in diseases
- Cardiovascular Function and Risk Factors
- Bioinformatics and Genomic Networks
- Random Matrices and Applications
- Animal Nutrition and Physiology
- Renal and related cancers
- Stochastic processes and statistical mechanics
- Plant-Microbe Interactions and Immunity
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Plant Pathogenic Bacteria Studies
- Prostate Cancer Diagnosis and Treatment
- Optimal Experimental Design Methods
- Toxic Organic Pollutants Impact
Janssen (United States)
2023-2025
Zhengzhou University of Aeronautics
2024
Beijing University of Technology
2024
Chinese Academy of Sciences
2004-2023
Institute of Genetics and Developmental Biology
2020-2023
China Agricultural University
2017-2023
Ministry of Agriculture and Rural Affairs
2021
University of Chinese Academy of Sciences
2020
Shenzhen University
2020
First Affiliated Hospital of Dalian Medical University
2009-2019
Organochlorine (OC) pesticides have been used broadly in China's past, yet very little is known about their atmospheric concentrations and transport. In this work, air samples were collected the Taihu Lake Region, China, from July 23 to August 11, 2002, measure of OC air. The average α γ- hexachlorocyclohexane (HCH), hexachlorobenzene (HCB), heptachlor (HEPT), α-endosulfan, p,p'-DDT, p,p'-DDE, p,p'-DDD, o,p'-DDT 74 46, 47, 53, 307, 124, 212, 36, 767 pg m-3, respectively. It was interesting...
In the United States and elsewhere, recreational water quality is monitored for fecal indicator bacteria to help prevent swimming-associated illnesses. Standard methods measure these take at least 24 hours obtain results. Molecular approaches such as quantitative polymerase chain reaction (qPCR) can estimate faster, in under 3 hours. Previously, we demonstrated that measurements of Enterococcus using qPCR were associated with gastrointestinal (GI) illness among swimmers freshwater beaches....
To compare the safety and efficiency of conventional monopolar, plasmakinetic holmium laser transurethral resection bladder tumor (CM-TURBT, PK-TURBT HoL-TURBT) while managing primary non-muscle invasive cancer.From 2005 to 2009, 173 patients with cancer underwent endoscopic surgery. Among them, 51 CM-TURBT, 58 PK-TURBT, 64 HoL-TURBT. All were divided into three risk groups (low, intermediate, high) based on European Association Urology guidelines prognostic factors recurrence. Clinical...
miR-409-3p/-5p is a miRNA expressed by embryonic stem cells, and its role in cancer biology metastasis unknown. Our pilot studies demonstrated elevated expression human prostate bone metastatic cell lines; therefore, we defined the biologic impact of manipulation on progression correlated levels with clinical specimens.miRNA profiling epithelial-to-mesenchymal transition (EMT) line model was performed. A Gleason score tissue array probed for validation specific miRNAs. In addition, genetic...
Combined sewer overflows (CSOs) occur in combined systems when sewage and stormwater runoff are released into water bodies, potentially contaminating sources. CSOs often caused by heavy precipitation expected to increase with increasing extreme associated climate change.The aim of this study was assess whether the association between rainfall rate emergency room (ER) visits for gastrointestinal (GI) illness differed presence CSOs.For period 2003-2007, time series daily ER GI meteorological...
Roux-en-Y gastric bypass (RYGB) is an effective method of weight loss and remediation type-2 diabetes; however, the mechanisms leading to these improvements are unclear. Additionally, adipocytes within white adipose tissue (WAT) depots can manifest characteristics brown adipocytes. These 'BRITE/beige' express uncoupling protein 1 (UCP1) associated with in glucose homeostasis protection from obesity. Interestingly, atrial B-type natriuretic peptides (NPs) promote BRITE/beige adipocyte...
Populations of Vibrio parahaemolyticus in the environment can be influenced by numerous factors. We assessed correlation total (tl+) and potentially virulent (tdh+) V. water with three harmful algal bloom (HAB) genera (Pseudo-nitzschia, Alexandrium Dinophysis), abundance diatoms dinoflagellates, chlorophyll-a temperature, salinity macronutrients at five sites Washington State from 2008–2009. The variability density was explained predominantly strong seasonal trends where maximum densities...
Obesity is a known risk factor for PDA and recent reports suggest obesity has negative impact on clinical outcomes in patients with PDA. Pretreatment body mass index (BMI) serum albumin (SA) have been shown to be associated worse overall survival advanced metastatic However, minimal data exists the of BMI SA perioperative long-term early-stage resected Herein, we report these variables outcomes, (OS) disease free (DFS) With IRB approval, evaluated 1,545 treated at single institution from...
Surgically excised keloids reportedly recur at a rate of >45%. Post-excision radiation (RT) has been delivered via external beam radiotherapy (EBRT) or interstitial high dose (HDR) brachytherapy. Despite historical data showing 10% to 20% keloid recurrences with post-excision RT, there is paucity high-quality evidence comparing between the two RT modalities.We performed largest single-institution case-control retrospective study (2004-2014) recurrence rates and complications EBRT HDR...
The microbiota of female reproductive tract have attracted considerable attention in recent years due to their effects on host fitness. However, the throughout chicken oviduct and its symbiotic relationships with not been well characterized. Here, we characterized microbial composition six segments tract, including infundibulum, magnum, isthmus, uterus, vagina cloaca, pedigreed laying hens phenotypes egg quality quantity. We found that diversity gradually increased along from infundibulum...
Abstract Incidences of harmful algal blooms (HABs) and Vibrio infections have increased over recent decades. Numerous studies tried to identify environmental factors driving HABs pathogenic populations separately. Few considered the two simultaneously, though emerging evidence suggests that enhance growth survival. This study examined various physical, nutrient, temporal associated with incidences HABs, V. vulnificus , parahaemolyticus in South Carolina coastal stormwater detention ponds,...
Women with signs and symptoms of ischemia, no obstructive coronary artery disease (CAD) preserved left ventricular ejection fraction (EF) often have diastolic dysfunction experience elevated rates major adverse cardiac events (MACE), including heart failure (HF) hospitalization (HFpEF). We evaluated the predictive value inflammatory biomarkers for long-term HF all-cause mortality in these women.We performed a cross-sectional analysis to investigate relationships between [serum interleukin-6...
Lethal progression of prostate cancer metastasis can be improved by developing animal models that recapitulate the clinical conditions. We report here cytokeratin 13 (KRT13), an intermediate filament protein, plays a directive role in bone, brain, and soft tissue metastases. KRT13 expression was elevated metastatic cell lines primary prostate, lung, breast specimens. When determined at single level tumor tissues 44 cases, predicted bone overall survival patients. Genetically enforced human...
Abstract We present a cancer phase I clinical trial design of combination two drugs with the goal estimating maximum tolerated dose curve in two‐dimensional Cartesian plane. A parametric model is used to describe relationship between doses agents and probability limiting toxicity. The re‐parameterized terms probabilities toxicities at combinations corresponding minimum available interaction parameter. Trial proceeds using cohorts patients receiving according univariate escalation overdose...
Seed germination is vital for ensuring the continuity of life in spermatophyte. High-quality seed usually represents good seedling establishment and plant production. Here, we identified OsLTPL23, a putative rice non-specific lipid transport protein, as an important regulator responsible germination. Subcellular localization analysis confirmed that OsLTPL23 present plasma membrane nucleus. The knockout mutants were generated by CRISPR/Cas9-mediated genome editing, osltpl23 lines...