A5101668727- Protein Interaction Studies and Fluorescence Analysis
- Sleep and related disorders
- Genetic Associations and Epidemiology
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Circadian rhythm and melatonin
- Molecular Sensors and Ion Detection
- Free Radicals and Antioxidants
- Advanced Sensor and Energy Harvesting Materials
- Computational Drug Discovery Methods
- Cancer, Lipids, and Metabolism
- Regulation of Appetite and Obesity
- Tryptophan and brain disorders
- Genetics, Aging, and Longevity in Model Organisms
- Diabetes and associated disorders
- Rock Mechanics and Modeling
- Machine Learning in Bioinformatics
- Biosimilars and Bioanalytical Methods
- Enzyme function and inhibition
- Hydrogels: synthesis, properties, applications
- Hormonal and reproductive studies
- Circular RNAs in diseases
- Advanced Polymer Synthesis and Characterization
- Genomics, phytochemicals, and oxidative stress
- Coal Properties and Utilization
First Affiliated Hospital of Henan University
2025
Guilin University of Technology
2023-2025
Capital Medical University
2022-2024
Anhui University of Science and Technology
2024
Shandong First Medical University
2020-2022
Zhejiang Gongshang University
2021-2022
Zhejiang Sci-Tech University
2022
Southwest University
2022
WuXi AppTec (China)
2020
University of Science and Technology Beijing
2013-2018
Background: Extensive studies put forward the association between Alzheimer’s disease (AD) and psychiatric disorders; however, it remains unclear whether these associations are causal. Objective: We aimed to assess potential causal relationship major disorders AD. Methods: A bidirectional two-sample Mendelian randomization (MR) was applied evaluate causality five AD by selecting single-nucleotide polymorphisms from genome-wide as instrumental variables. Inverse-variance weighted (IVW) method...
ABSTRACT Poly(dimethylaminoethyl methacrylate) hydrogels containing cholic acid (PDMAEMA–CA) were synthesized by radiation crosslinking. The introduction of 10 and 20 mol% (CA) into the poly(dimethylaminoethyl (PDMAEMA) hydrogel decreased maximum swelling ratio (SR) gel from 40 to 6 5, respectively. incorporation CA with dimethylaminoethyl methacrylate led a decrease in lower critical temperature 44 42°C but did not exert big influence on ion‐stimulus‐responsive properties gel. However, pH...
Observational studies revealed changes in Immunoglobulin G (IgG) N-glycosylation during the aging process. However, it lacks causal insights and remains unclear which direction relationships exist. The two-sample bidirectional Mendelian randomization (MR) design was adopted to explore associations between IgG N-glycans senescence-associated secretory phenotype (SASP). Inverse variance weighted (IVW) Wald ratio methods were used as main analyses, supplemented by sensitivity analyses. Forward...
In order to reduce the occupational health hazard of coal dust miners, surface tension and viscosity tests bituminous powder sedimentation experiments were conducted. A composite suppressant with bonding-wetting effects was developed. Meanwhile, based on FTIR test peak-differentiating curve fitting, changes peak areas samples before after treatment investigated, quantitative analysis hydrophilic hydrophobic groups. Gravity drop weight Malvern particle size analyses carried out. The...
In this paper, we introduce a kind of tertiary amine-based CO2-responsive material combining with the H2O2-responsive to develop dual-responsive self-propulsion smart device which can convert chemical energy H2O2 into mechanical steadily through diving–surfacing cycles. device, is designed as wettability conversion species, wrapped strip platinum catalyze decomposition generate gaseous O2 realize surfacing. deionized water, floats on surface water initially and perform cycle when CO2 stimuli...
We reported the pharmacokinetic/pharmacodynamic (PK/PD) targets of a biosimilar generic product amphotericin B colloidal dispersion (G-ABCD) againstCandida albicans (MIC 1-2 μg/mL) in rat model invasive candidiasis (IC) to facilitate its precision administration.Single-dose plasma PKs G-ABCD was studied IC following intravenous administration at doses 0.0625-10 mg/kg. Amphotericin concentrations were determined and PK parameters calculated based on plasma. The efficacy evaluated after single...
Mammary gland hyperplasia (MGH) is very common, especially among young and middle-aged women. New diagnostics biomarkers for MGH are needed rational clinical management precision medicine. We report, in this study, new findings using a glycomics approach, with focus on immunoglobulin G (IgG) N-glycosylation. A cross-sectional study was conducted community-based population sample Beijing, China. total of 387 participants 40–65 years age were enrolled including 194 women (cases) 193 who had no...
Perfluorinated compounds (PFCs) belong to a significant category of global environmental pollutants. Investigating the toxicological effects PFCs within biological systems is critical significance in various disciplines such as life sciences, science, chemistry, and ecotoxicology. In this study, under simulated human physiological conditions (pH = 7.4), combination multiple spectroscopic techniques computational simulations was employed investigate impact perfluorinated on G protein-coupled...
Abstract The aim of this study was to understand the interaction between transthyretin (TTR) and halogenated phenols (HPs) including 2,4‐dichlorophenol (DCP), 2,4,6‐trichlorophenol (TCP), pentachlorophenol (PCP), 2‐bromophenol (2‐BP), 2,4‐dibromophenol (DBP) 2,4,6‐tribromophenol (TBP). Computer simulation multi‐spectroscopy techniques were used investigate interaction. fluorescence TTR found be quenched through static quenching non‐radiative energy transfer by HPs, suggesting that binding...
Background: Night-shift workers are exposed to nocturnal light and more prone develop circadian rhythm disorders. Although night-shift work is thought be associated with decreasing levels of melatonin, studies have showed inconsistent results. Methods: This systematic review meta-analysis studied the association between melatonin its metabolite, 6-sulfatoxymelatonin (aMT6s). PubMed EMBASE databases were searched up August 30, 2019. The difference in day was statistically quantified by...
The aim of this study was to understand the interaction between transthyretin (TTR) and halogenated phenols (HPs) including 2,4-dichlorophenol (DCP), 2,4,6-trichlorophenol (TCP), pentachlorophenol (PCP), 2-bromophenol (2-BP), 2,4-dibromophenol (DBP) 2,4,6-tribromophenol (TBP). Computer simulation multi-spectroscopy techniques were used investigate interaction. fluorescence TTR found be quenched through static quenching non-radiative energy transfer by HPs, suggesting that binding process HPs...