Fangfang Chao

ORCID: 0000-0001-5254-1560
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About
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Research Areas
  • Medical Imaging Techniques and Applications
  • Sarcoma Diagnosis and Treatment
  • Radiopharmaceutical Chemistry and Applications
  • Mesenchymal stem cell research
  • Neuroscience and Music Perception
  • Glioma Diagnosis and Treatment
  • Neurogenesis and neuroplasticity mechanisms
  • Music Therapy and Health
  • Radiomics and Machine Learning in Medical Imaging
  • Bone Tumor Diagnosis and Treatments
  • Cancer, Hypoxia, and Metabolism
  • Orthopaedic implants and arthroplasty
  • Digital Mental Health Interventions
  • Cardiac tumors and thrombi
  • Peptidase Inhibition and Analysis
  • Neural dynamics and brain function
  • Diverse Music Education Insights
  • Cardiac Imaging and Diagnostics
  • RNA modifications and cancer
  • Lymphoma Diagnosis and Treatment
  • Pluripotent Stem Cells Research
  • Thyroid Cancer Diagnosis and Treatment
  • Lung Cancer Diagnosis and Treatment
  • Child Development and Digital Technology
  • Gastrointestinal Tumor Research and Treatment

First Affiliated Hospital of Zhengzhou University
2023-2025

Second Affiliated Hospital of Zhejiang University
2012-2017

Zhejiang University
2012-2017

Zhejiang Chinese Medical University
2012-2017

Trop2 exhibits significantly elevated expression in numerous solid malignancies, playing a crucial role tumor advancement, whereas its presence healthy tissues is minimal. In this study, we investigated bladder cancer models using [64Cu]Cu-NOTA-Trodelvy for immunoPET imaging. HT-1376 models, effectively visualized as early 12 h p.i. (10.30 ± 1.45% ID/g), with uptake increasing and peaking at 48 (13.73 1.16% highlighting potential Control groups also demonstrated low (5.27 1.14% ID/g the...

10.1021/acs.molpharmaceut.5c00069 article EN Molecular Pharmaceutics 2025-03-09

The purpose of this study was to determine the functionality transplanted induced pluripotent stem cells (iPSCs) and embryonic (ESCs) in a rat model cerebral ischemia with use <sup>18</sup>F-FDG small-animal PET imaging. <b>Methods:</b> Middle artery occlusion used establish ischemia. Twenty-four male rats were randomly assigned 1 3 groups: iPSC treatment, ESC control phosphate-buffered saline (PBS) injection. After neurologic function tests baseline had been performed, 1.0 × 10<sup>6</sup>...

10.2967/jnumed.112.111112 article EN Journal of Nuclear Medicine 2013-03-15

Abstract Background The aim of the present study was to evaluate impact intratumoral metabolic heterogeneity and quantitative 18 F‐FDG PET/CT imaging parameters in predicting patient outcomes thymic epithelial tumors (TETs). Methods This retrospective included 100 patients diagnosed with TETs who underwent pretreatment PET/CT. maximum mean standardized uptake values (SUVmax SUVmean), tumor volume (MTV), total lesion glycolysis (TLG) on were measured. Heterogeneity index‐1 (HI‐1; standard...

10.1111/1759-7714.15331 article EN cc-by-nc-nd Thoracic Cancer 2024-05-16

This study reports the synthesis and evaluation studies of 6′‐cyclopentadienyl tricarbonyl technetium‐99m 6′‐oxo‐11‐(hexanamide)undecanoic acid (1). 1 was prepared with 26.5 ± 4.3% radiochemical yield more than 98% purity. Tissue distribution in mice showed that high radioactivity accumulated heart moderate clearance. However, unfortunately, similar to those other technetium‐labeled fatty analogs, biodistribution poor heart‐to‐blood ratios, which suggested cannot be used as myocardial...

10.1002/jlcr.2987 article EN Journal of Labelled Compounds and Radiopharmaceuticals 2012-12-07

Frightening music can rapidly arouse emotions in listeners that mimic those from actual life-threatening experiences. However, studies of the underlying mechanism for perceiving danger created by are limited. <b>Methods:</b> We investigated monoamine receptor changes induced frightening using <sup>11</sup>C-<i>N</i>-methyl-spiperone (<sup>11</sup>C-NMSP) PET. Ten healthy male volunteers were included, and their psychophysiologic evaluated. <b>Results:</b> Compared with baseline condition,...

10.2967/jnumed.112.106690 article EN Journal of Nuclear Medicine 2012-08-29

In the follow-up of patients with differentiated thyroid cancer (DTC), several had elevated serum levels antithyroglobulin antibody (TgAb), undetectable thyroglobulin (Tg), and negative radioiodine whole body scan (131I-WBS). We describe use neck ultrasonography (US) fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) imaging in these to investigate this clinically challenging problem propose treating.A total 49 DTC TgAb (>115IU/mL), Tg 131I-WBS...

10.1967/s002449910703 article EN PubMed 2018-03-20

Background: Primary adrenal diffuse large B-cell lymphoma (PA-DLBCL) is a rare occurrence, has very poor prognosis, and marked by high risk of relapse. Accurate prediction patient prognosis before treatment initiation, along with timely adjustment the plan, holds paramount importance. 2-Deoxy-2-[fluorine-18]-fluoro-D-glucose (18F-FDG) positron emission tomography combined computed (PET/CT) imaging techniques are conventionally performed prior to initiation in DLBCL patients, offering...

10.21037/qims-23-803 article EN Quantitative Imaging in Medicine and Surgery 2023-11-24

Myxoid liposarcoma (MLS) is a rare malignant soft tissue sarcoma that predominantly manifests in the deep tissues of extremities, particularly within musculature thigh. Unlike other types liposarcoma, MLS demonstrates propensity for metastasis to atypical sites, including lung parenchyma, tissues, retroperitoneum, mediastinum, breast, liver, thymus, lymph nodes, and bones. The definitive diagnosis primarily relies on histology with HE staining. Imaging modalities such as ultrasound, CT, MRI,...

10.3389/fmed.2023.1235843 article EN cc-by Frontiers in Medicine 2023-07-27
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