A5088524066- Breast Cancer Treatment Studies
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Breast Lesions and Carcinomas
- Cancer and Skin Lesions
- Gastrointestinal disorders and treatments
- Genetic factors in colorectal cancer
- Metastasis and carcinoma case studies
- Cancer Diagnosis and Treatment
- Macrophage Migration Inhibitory Factor
- Thyroid Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Helicobacter pylori-related gastroenterology studies
- Salivary Gland Tumors Diagnosis and Treatment
- Breast Implant and Reconstruction
- Pediatric Hepatobiliary Diseases and Treatments
- Endometrial and Cervical Cancer Treatments
- Liver Diseases and Immunity
- Hepatitis B Virus Studies
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
Woodhull Medical and Mental Health Center
2024
Clínica Alemana
2019-2024
Hospital Universitario Fundación Jiménez Díaz
1996-2023
Hospital San Pedro
2015-2022
Universidad del Desarrollo
2022
Software (Spain)
2019
Clinica Universidad de Navarra
2003-2017
Hospital Universitari de Vic
2016-2017
Gobierno de La Rioja
2016
Hospital Universitario Virgen del Rocío
2015
microRNAs (miRNA) are small RNAs that function as post-transcriptional regulators of gene expression. Recent evidence has shown some miRNAs can act oncogenes or tumor suppressors. This study was conducted to evaluate the potential association miRNA expression with clinical outcome in patients gastric cancer.Expression 250 human mature measured by real-time PCR on paraffin-embedded samples 21 cancer stage III uniformly treated surgical resection followed chemoradiation. We identified...
Abstract Many antitumor therapies affect rapidly dividing cells. However, tumor proliferation may be driven by cancer stem cells (CSCs), which divide slowly and are relatively resistant to cytotoxic drugs. Thus, many tumors progress because CSCs not sensitive the treatment. In this work, we searched for target genes whose expression is involved in chemoresistance of CSCs. Both these processes could controlled simultaneously cell regulators such as microRNAs (miRNAs). Therefore, colonospheres...
Abstract Given the long-term ineffectiveness of current therapies and late-stage diagnoses, lung cancer is a leading cause malignant diseases. Tumor progression influenced by cell interactions with tumor microenvironment (TME). Insulin-like growth factor 1 receptor (IGF1R) was reported to affect TME; however, role IGF1R in TME has not been investigated. First, we assessed genomic alterations expression NSCLC patient tissue samples, as well serum levels. Next, performed heterotopic...
Expansions of more than 30 hexanucleotide repetitions in the C9ORF72 gene are a common cause frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS). However, range 20-30 is rarely found and still has unclear significance. A screening our cohort cases with FTD (n = 109) revealed 4 mutation carriers (>30 repetitions) but also 5 probands 20-22 confirmed repetitions. This study explored possible pathogenic correlation repeats expansion (short expansion).Comparison clinical...
Recipients of liver transplantation (LT) may develop immunological tolerance. Factors predictive tolerance are not clearly understood. Transplant recipients with normal function tests and without active viral hepatitis or autoimmune disease who presented side effects immunosuppression a high risk de novo malignancies were selected to participate in this prospective study. Twenty-four patients fulfilled the inclusion criteria and, therefore, underwent gradual reduction immunosuppression....
Summary This study aims to establish the relative effectiveness and safety of low molecular weight heparin in elderly patients with venous thrombosis order find an alternative oral anticoagulant therapy less bleeding complications long-term treatment deep (DVT). One hundred consecutive (>75 years old) venographically demonstrated proximal DVT were included a randomized trial. All treated for ten days adjusted doses intravenous heparin. Informed consent was obtained on eight day, randomly...
This study aims to evaluate large cell carcinomas (LCC) of the lung with a panel immunohistochemical markers in an attempt identify tumors belonging other categories. We analyzed tissue microarray platform 101 LCC 31 monoclonal antibodies. The were 82 (81.3%) classic LCC, 7 (6.9%) neuroendocrine 6 (5.9%) lymphoepithelioma-like 3 (2.9%) basaloid 2 (2%) clear and 1 (1%) rhabdoid phenotype. Characteristic immunophenotype was loss staining CK5/6, CK14 positive most squamous carcinoma (SCC), lack...
The finding that some rectal cancers respond to neoadjuvant chemoradiation is broadening new surgical options for the treatment of these tumors that, until now, required a total mesorectal excision. Nevertheless, fine match between clinical and pathological response when planning conservative approaches.This study aims prospectively validate use endoscopic ultrasound as predictor tumor in patients with locally advanced cancer.: This an observational cohort undergoing followed by surgery.This...
The degree of histopathological response after neoadjuvant therapy in locally advanced gastric cancer (GC) is a key determinant patients' long-term outcome. We aimed to assess the pattern regression two approaches and its impact on survival times.Regression grade primary tumour (Becker criteria) nodal by 4-point scale (grades A-D) were assessed. Grade A-true negative lymph nodes (LNs); B C-infiltrated LNs with any or little evidence response; D-complete pathological previously infiltrated...
BACKGROUND The distinction between pleural mesothelioma (MS), reactive mesothelium (RM), and adenocarcinoma (AC) in serous effusions continues as a diagnostic problem pathology. Immunohistochemistry can help, especially surgical samples, but the optimum panel of antibodies has yet to be reported. application these displayed variable results. aim this study was evaluate usefulness eight monoclonal differential diagnosis MS, RM, AC effusions. METHODS A total 44 cytologic specimens (26 pleural,...
Four patients who received dural grafts of cadaveric origin in the course posterior fossa procedures subsequently developed Creutzfeldt-Jakob disease (CJD). The interval from placement to clinical onset CJD ranged 16 months nine years. Initial presentation consisted cerebellar symptoms, with dementia and myoclonus developing later stages disease. EEGs showed diffuse slowing that evolved a periodic activity pattern. CT MRI were unremarkable early but pronounced cerebral atrophy widened sulci...
Preoperative chemotherapy followed by radical surgery is a novel therapeutic approach for locally advanced colon cancer (LACC). Neoadjuvant strategies require highly accurate diagnostic tests proper selection of candidate patients, allowing low risk overtreatment. This paper assesses the radiological, metabolic and pathological findings induced preoperative oxaliplatin fluoropyrimidines-based in LACC.Forty-four consecutive patients with confirmed diagnosis LACC who received neoadjuvant were...
Abstract The value of intraoperative frozen-section biopsy thyroid nodules (solitary or dominant in a multinodular goitre) was examined patients who underwent fine-needle aspiration cytology (FNAC) for diagnosis before operation. A total 170 consecutive were evaluated and classified according to whether the cytological benign, suspicious malignant. In benign group, diagnostic accuracy 98 per cent FNAC 97 biopsy. those with cytology, 12 96 malignant there 100 76 Intraoperative by frozen...
ABSTRACT— We studied liver changes in the hepatic biopsies of five patients with hyperthyroidism. A characteristic histopathologic picture consisting mild to moderate intrahepatocytic cholestasis, lobular inflammatory infiltrate some eosinophils, and Kupffer cell hyperplasia was found all cases. discuss specificity, clinico‐pathological correlations possible pathophysiology these lesions.
Neoadjuvant chemoradiotherapy followed by total mesorectal excision has improved the outcome of locally advanced rectal carcinoma.The aim this study was to identify independent prognosis factors disease recurrence in a group patients treated with approach.This retrospective design. Data from cancer who had completed treatment 2000 2010 were reviewed.The analysis performed tertiary referral center.The primary outcomes measured risk factors.The cohort consisted 228 patients; 69.3% them men,...
Salivary duct carcinoma (SDC) is a rare high-grade aggressive neoplasm that manifests close histologic features with invasive ductal of the breast (IDC). In contrast to SDC, extensive molecular studies have been performed on IDC and led identification certain biological markers. To investigate underlying biologic characteristics we analyses using microsatellite markers chromosomal arms 6q, 16q, 17p, 17q, DNA flow cytometry immunohistochemical staining for androgen receptor (AR) p53...
The role of circulating tumor markers in providing prognostic information has not been widely studied. In the current study, serum levels carbohydrate antigen 15-3 (CA 15-3) and carcinoembryonic (CEA) were determined preoperatively 364 breast cancer patients with no clinical signs metastasis. relevance these for recurrence (175/364) death disease (104/175) was by Cox multivariate analysis, including comparison classical factors. High both associated aneuploid tumors high S-phase fraction...