A5042529673- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Macrophage Migration Inhibitory Factor
- Colorectal Cancer Screening and Detection
- Cancer, Hypoxia, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Treatments and Mutations
- Prostate Cancer Treatment and Research
- GDF15 and Related Biomarkers
- Pancreatic and Hepatic Oncology Research
- Helicobacter pylori-related gastroenterology studies
- Empathy and Medical Education
- Carbon dioxide utilization in catalysis
- Soft tissue tumors and treatment
- ATP Synthase and ATPases Research
- Breast Cancer Treatment Studies
- Proteoglycans and glycosaminoglycans research
- Esophageal and GI Pathology
- Testicular diseases and treatments
Clinica Universidad de Navarra
2006-2024
Universidad de Navarra
2006-2019
Memorial Sloan Kettering Cancer Center
2005-2008
The University of Texas MD Anderson Cancer Center
2008
University of Padua
2008
National Cancer Center
2008
Hospital General Dr Aurelio Valdivieso
2007
National Cancer Center
2006
Hospital General Universitario Gregorio Marañón
2001-2006
Radiation Oncology Associates
2006
microRNAs (miRNA) are small RNAs that function as post-transcriptional regulators of gene expression. Recent evidence has shown some miRNAs can act oncogenes or tumor suppressors. This study was conducted to evaluate the potential association miRNA expression with clinical outcome in patients gastric cancer.Expression 250 human mature measured by real-time PCR on paraffin-embedded samples 21 cancer stage III uniformly treated surgical resection followed chemoradiation. We identified...
Purpose Although combined-modality therapy (CMT) is the preferred treatment for T3 and/or lymph node (LN)-positive rectal cancer, German cancer study published in 2004 demonstrated that 18% of patients deemed suitable preoperative CMT by endorectal ultrasound (ERUS) may be overstaged. Because data also suggest LN-negative after total mesorectal excision not require radiotherapy, it reasonable to consider omitting radiotherapy cT3N0 subset. We therefore determined accuracy pre-CMT ERUS or...
Abstract Background There is strong evidence demonstrating that activation of epidermal growth factor receptors (EGFRs) leads to tumor growth, progression, invasion and metastasis. Erlotinib gefitinib, two EGFR-targeted agents, have been shown be relevant drugs for lung cancer treatment. Recent studies demonstrate lapatinib, a dual tyrosine kinase inhibitor EGFR HER-2 receptors, clinically effective against HER-2-overexpressing metastatic breast cancer. In this report, we investigated the...
The degree of histopathological response after neoadjuvant therapy in locally advanced gastric cancer (GC) is a key determinant patients' long-term outcome. We aimed to assess the pattern regression two approaches and its impact on survival times.Regression grade primary tumour (Becker criteria) nodal by 4-point scale (grades A-D) were assessed. Grade A-true negative lymph nodes (LNs); B C-infiltrated LNs with any or little evidence response; D-complete pathological previously infiltrated...
Radiotherapy (RT) is a common treatment for localised prostate cancer, but can cause important side effects. The therapeutic efficacy of RT be enhanced by pharmacological compounds that target specific pathways involved in cell survival. This would elicit similar response using lower doses and, turn, reducing study describes the antitumour activity novel Akt inhibitor 8-(1-Hydroxy-ethyl)-2-methoxy-3-(4-methoxy-benzyloxy)-benzo[c]chromen-6-one (Palomid 529 or P529) as well its ability to...
We have used immunohistochemistry to examine the dynamics of tumor hypoxia.. Expression CAIX is known be influenced by hypoxia, and this protein has been shown an endogenous hypoxia marker in several models. However, due its long half-life, it could also present oxygenated tissue that had recently hypoxic. To investigate issue we compared expression exogenous marker, pimonidazole using HT29 (human colorectal cancer) xenografts. manipulated with carbogen hydralazine, treatments respectively...
Tumour response evaluation after chemotherapy has become crucial in the development of many drugs. In contrast to standard bidimensional WHO criteria, recently described Response Evaluation Criteria Solid Tumors are based on unidimensional measurements. The aim present study was compare both methods patients with metastatic non-small cell lung cancer. One hundred and sixty-four treated two cisplatin-paclitaxel-based schedules between June 1994 December 2000 were analysed. measurements...
Se describen el diseño y la puesta en marcha de un proyecto docente Facultad Medicina Universidad Navarra dirigido a promover una fuerte identidad médica centrada paciente que armonice desarrollo personal profesional los futuros médicos. La acción educativa se lleva cabo 3 fases consecutivas. primera consiste unos talleres previos las rotaciones clínicas reflexiona, manera participativa, sobre aspecto seleccionado. En segundo momento, alumno identificará manifestaciones concretas ese...
Pterygium is one of the most common conjunctival diseases among ophthalmic pathologies. The frequency recurrences high, either after surgical treatment or combined with mitomycin C beta-radiation therapy.The purpose this study was to determine whether concanavalin A (ConA) lectin bound pterygial surface can be used detect recurrence remnants pterygium excision.This a prospective on 20 patients pterygium, divided in five stages, pre-surgery, early post-surgery (24h), late (seven days), very...