A5025326086- Biomedical Text Mining and Ontologies
- Scientific Computing and Data Management
- Semantic Web and Ontologies
- Bioinformatics and Genomic Networks
- Genomics and Phylogenetic Studies
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Gene expression and cancer classification
- Muscle activation and electromyography studies
- Neuroscience and Neural Engineering
- Cancer-related molecular mechanisms research
- Genetics, Bioinformatics, and Biomedical Research
- Epigenetics and DNA Methylation
- Analog and Mixed-Signal Circuit Design
- Alzheimer's disease research and treatments
- Advanced Proteomics Techniques and Applications
- Data Quality and Management
- MicroRNA in disease regulation
- Machine Learning in Bioinformatics
- RNA and protein synthesis mechanisms
- stochastic dynamics and bifurcation
- Microbial Metabolic Engineering and Bioproduction
- Bone Tumor Diagnosis and Treatments
- Child Development and Education
- Dietary Effects on Health
Universitat Politècnica de Catalunya
2023-2024
Barcelona Supercomputing Center
2023-2024
Universidad de Navarra
2002-2024
Navarrabiomed
2014-2020
Universidad Publica de Navarra
2001-2020
Departamento de Salud
2018
Universidad de Granada
2009-2017
Research Organization of Information and Systems
2011-2013
Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research
2012
European Bioinformatics Institute
2007-2008
InterPro is an integrated resource for protein families, domains and functional sites, which integrates the following signature databases: PROSITE, PRINTS, ProDom, Pfam, SMART, TIGRFAMs, PIRSF, SUPERFAMILY, Gene3D PANTHER. The latter two new member databases have been since last publication in this journal. There several developments InterPro, including additional reading field, database links, extensions to web interface match XML files. has always provided matches UniProtKB proteins on...
Rapid advances in DNA sequencing promise to enable new diagnostics and individualized therapies. Achieving personalized medicine, however, will require extensive research on highly reidentifiable, integrated datasets of genomic health information. To assist with this, participants the Personal Genome Project choose forgo privacy via our institutional review board- approved “open consent” process. The contribution public data samples facilitates both scientific discovery standardization...
We present a new version of the European Bioinformatics Institute Web Services, complete suite SOAP-based web tools for structural and functional analysis, with improved applications. New functionality has been added to most services already available, an underlying framework allowed us include more
Drawing the epigenome landscape of Alzheimer's disease (AD) still remains a challenge. To characterize epigenetic molecular basis human hippocampus in AD, we profiled genome-wide DNA methylation levels hippocampal samples from cohort pure AD patients and controls by using Illumina 450K arrays. Up to 118 AD-related differentially methylated positions (DMPs) were identified hippocampus, extended mapping specific regions was obtained bisulfite cloning sequencing. DMPs significantly correlated...
The discovery of novel biomarkers stroke etiology would be most helpful in management acute ischemic patients. Recently, circular RNAs (circRNAs) have been proposed as candidate neurological conditions due to its high stability. circRNAs function sponges, sequestering miRNAs and are involved relevant biological functions. Our aim was identify differentially expressed patients according etiology.A comprehensive expression profile blood conducted by Arraystar Human circRNA arrays (13,617...
We studied the effect of stimulus predictability on alpha and beta changes observed in central regions during stimulus-induced movement paradigms. Six young volunteers were instructed to extend briskly their dominant wrist as soon possible after hearing a 2000 Hz sound. Two sequences stimuli presented each subject, first rhythmic at 1/6 s second with random intervals between 5 13s. A time-frequency analysis nonphase-locked activity 7–37 range was performed stimulus-centred EEG sweeps using...
The Ensembl Trace Archive ( http://trace.ensembl.org/ ) and the EMBL Nucleotide Sequence Database http://www.ebi.ac.uk/embl/ ), known together as European Archive, continue to see growth in data volume diversity. Selected major developments of 2007 are presented briefly, along with submission retrieval information. In face increasing requirements for nucleotide trace, sequence annotation archiving, capture priority decisions have been taken at Archive. Priorities discussed terms how reliably...
The structure of many eukaryotic cell regulatory proteins is highly modular. They are assembled from globular domains, segments natively disordered polypeptides and short linear motifs. latter involved in protein interactions formation complexes. function such proteins, which may be difficult to define, the aggregate subfunctions modules. It therefore desirable efficiently predict motifs with some degree accuracy, yet sequence database searches return results that not significant.We have...
Thrombotic material retrieved from acute ischemic stroke (AIS) patients represents a valuable source of biological information. In this study, we have developed clinical proteomics workflow to characterize the protein cargo thrombi derived AIS patients. To analyze thrombus proteome in large-scale format, that combines isolation by endovascular thrombectomy and peptide chromatographic fractionation coupled mass-spectrometry. Using workflow, characterized specific proteomic expression profile...
Abstract Mindfulness and meditation techniques have proven successful for the reduction of stress improvement in general health. In addition, is linked to longevity longer telomere length, a proposed biomarker human aging. Interestingly, DNA methylation changes been described at specific subtelomeric regions long-term meditators compared controls. However, molecular basis underlying these beneficial effects on health still remains unclear. Here we show that levels, measured by Infinium...
Recent advancements in high-throughput omics technologies have opened new avenues for investigating stroke at the molecular level and elucidating intricate interactions among various components. We present a novel approach multi-omics data integration on knowledge graphs applied it to etiology classification task of 30 patients through integrative analysis DNA methylation mRNA, miRNA, circRNA. This has demonstrated promising performance as compared other existing single technology approaches.
BioHackathon 2010 was the third in a series of meetings hosted by Database Center for Life Sciences (DBCLS) Tokyo, Japan. The overall goal is to improve quality and accessibility life science research data on Web bringing together representatives from public databases, analytical tool providers, cyber-infrastructure researchers jointly tackle important challenges area silico biological research. theme 'Semantic Web', all attendees gathered with shared producing Semantic their respective...
The discovery of new biomarkers would be very valuable to improve the detection early Alzheimer's disease (AD). DNA methylation marks may serve as epigenetic AD. Here we identified that are present in human hippocampus from earliest stages A previous methylome dataset AD was used select a set eight differentially methylated positions (DMPs) since stages. Next, bisulphite pyrosequencing performed an expanded homogeneous cohort 18 pure controls and 35 hippocampal samples with neuropathological...
Abstract Summary: Dasty2 is a highly interactive web client integrating protein sequence annotations from currently more than 40 sources, using the distributed annotation system (DAS). Availability: an open source tool freely available under terms of Apache License 2.0, publicly at http://www.ebi.ac.uk/dasty/ Contact: hhe@ebi.ac.uk
Programmatic access to data and tools through the web using so-called services has an important role play in bioinformatics. In this article, we discuss most popular approaches based on SOAP/WS-I REST describe our, a cross section of community, experiences with providing context biological sequence analysis. We briefly review main technological as well best practice hints that are useful for both users developers. Finally, syntactic semantic integration issues multiple discussed.