A5031252393- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Luminescence and Fluorescent Materials
- Innovative Microfluidic and Catalytic Techniques Innovation
- CRISPR and Genetic Engineering
- Dendrimers and Hyperbranched Polymers
- Organic Electronics and Photovoltaics
- Conducting polymers and applications
- Biosensors and Analytical Detection
- Cancer Research and Treatments
- Organic Light-Emitting Diodes Research
- Cancer Cells and Metastasis
- Gut microbiota and health
- RNA Interference and Gene Delivery
- Gold and Silver Nanoparticles Synthesis and Applications
- 3D Printing in Biomedical Research
- Immunotherapy and Immune Responses
- Pickering emulsions and particle stabilization
- Telomeres, Telomerase, and Senescence
- RNA Research and Splicing
- Molecular Biology Techniques and Applications
- Microfluidic and Capillary Electrophoresis Applications
- Bone Metabolism and Diseases
- interferon and immune responses
Nanjing University
2019-2025
Collaborative Innovation Center of Advanced Microstructures
2022-2025
National Laboratory of Solid State Microstructures
2022-2025
Hebei University of Science and Technology
2024
State Key Laboratory of Analytical Chemistry for Life Science
2020-2024
Shanxi Datong University
2022-2024
Nanjing Medical University
2023
Riverside Hospital of Guangxi Zhuang Autonomous Region
2023
University of Chinese Academy of Sciences
2022
Shanghai Electric (China)
2022
Remote-controlled manipulation of gene editing was achieved in vivo.
Near-infrared (NIR)-light-triggered photothermal therapy (PTT) is usually associated with undesirable damage to healthy organs nearby due the high temperatures (>50 °C) available for tumor ablation. Low-temperature PTT would therefore have tremendous value clinical application. Here, we construct a hypoxia-responsive gold nanorods (AuNRs)-based nanocomposite of CRISPR-Cas9 mild-photothermal via tumor-targeted gene editing. AuNRs are modified azobenzene-4,4'-dicarboxylic acid (p-AZO) achieve...
Cuproptosis has drawn enormous attention in antitumor material fields; however, the responsive activation of cuproptosis against tumors using nanomaterials with high atom utilization is still challenging. Herein, a copper-based nanoplatform consisting acid-degradable copper hydride (CuH) nanoparticles was developed via microfluidic synthesis. After coating tumor-targeting hyaluronic acid (HA), denoted as HA-CuH-PVP (HCP) shows conspicuous damage toward tumor cells by generating Cu+ and...
An enantioselective synthesis of INCB018424 via organocatalytic asymmetric aza-Michael addition pyrazoles (16 or 20) to (E)-3-cyclopentylacrylaldehyde (23) using diarylprolinol silyl ether as the catalyst was developed. Michael adducts (R)-24 and (R)-27 were isolated in good yield high ee readily converted INCB018424.
CRISPR/Cas12a has shown great potential in molecular diagnostics, but its application sensing of microRNAs (miRNAs) was limited by sensitivity and complexity. Here, we have sensitively conveniently detected reasonably integrating metal–organic frameworks (MOFs) based biobarcodes with assay (designated as MBCA). In this work, DNA-functionalized Zr-MOFs were designed the converter to convert amplify each miRNA target into activators that can initiate trans-cleavage activity further signal....
Tumor whole cell, carrying a complete set of tumor-associated antigens and tumor-specific antigens, has shown great potential in the construction tumor vaccines but is hindered by complex engineering means limited efficacy to cause immunity. Herein, we provided strategy for self-mineralization autologous cells with palladium ions microfluidic droplets, which endowed engineered both immune catalytic functions, establish bioorthogonally whole-cell vaccine. This vaccine showed strong inhibition...
The optical and photophysical properties of phenylacetylene dendritic macromolecules based on unsymmetrical branching are investigated using steady-state time-dependent spectroscopy. Monodendrons, up to the fourth generation, characterized with without a fluorescent perylene trap at core. higher generation monodendrons exhibit high molar extinction coefficients (>10(5) M(-1) cm(-1)) fluorescence quantum yields (65-81%). When is placed core, then typically energy transfer (approximately 90%),...
Inflammatory bowel disease (IBD) is a chronic relapsing autoimmune with rising incidence worldwide. There an increasing desire for non-invasive diagnostic tools to enable simple and sensitive IBD monitoring. Here, we report orally administered nanosensor which will dissociate into ultrasmall platinum nanoclusters (PtNCs) in IBD-related inflammatory microenvironments. By exploiting the enzyme-mimicking activity of PtNCs precise bandpass filterability kidney, released-PtNCs can be detected...
Targeted construction of therapeutic nanoplatforms in tumor cells with specific activation remains appealing but challenging. Here, we design a cancer-motivated upconversion nanomachine (UCNM) based on porous nanoparticles (p-UCNPs) for precise phototherapy. The nanosystem is equipped telomerase substrate (TS) primer and simultaneously encapsulates 5-aminolevulinic acid (5-ALA) d-arginine (d-Arg). After coating hyaluronic (HA), it can readily get into cells, where 5-ALA induces efficient...
Abstract Colonization of cancer cells at secondary sites, a decisive step in tumor metastasis, is strongly dependent on the formation metastatic microenvironments regulated by intrinsic single‐cell metabolism traits. Herein, we report microfluidic platform for high‐throughput dynamic monitoring cell metabolites to evaluate malignancy. This device empowers efficient isolation single (>99 %) squashed state similar extravasation, and employs enzyme‐packaged metal–organic frameworks catalyze...
Background: The gut microbiota (GM) constitutes a critical factor in the maintenance of physiological homeostasis. Numerous studies have empirically demonstrated that GM is closely associated with onset and progression osteoporosis (OP). Nevertheless, characteristics its metabolites related to different forms OP are poorly understood. In present study, we examined changes various types as well correlations among them. Methods: We simultaneously established rat postmenopausal, disuse-induced,...
Abstract Inflammatory bowel disease (IBD) is a chronic relapsing autoimmune that characterized by segmental intestinal inflammation. There an urgent need for more efficient inflammation‐targeting strategies to improve therapeutic effect and reduce systemic drug exposure. Herein, oxidation‐responsive metal–organic framework material (Ce‐MOF@PSS) reported preferentially adheres inflamed intestine via enema. The overproduced reactive oxygen species (ROS) at inflammatory sites induces...
Cancer has become a leading cause of morbidity and mortality, there is an increasing need for versatile tools to enable sensitive, simple early cancer monitoring. Here, we report platinum supernanoparticles as exogenous nanosensor which can dissociate into ultrasmall nanoclusters (PtNCs) under tumor-specific hypoxia conditions. The resulting PtNCs be filtered through the kidney urinary reporters quantified by companion volumetric bar-chart chip (V-Chip) point-of-care analysis. V-Chip signals...
Abstract As a promising therapeutic modality targeting cancer, gas therapy still faces critical challenges, especially in enhancing efficacy and avoiding poisoning risks. Here, pH/glutathione (GSH) dual stimuli‐responsive CRISPR/Cas9 gene‐editing nanoplatform combined with calcium‐enhanced CO for precise anticancer therapy, is established. In the tumor microenvironment (TME), fast biodegradation of CaCO 3 layer via pH‐induced hydrolyzation allows glucose oxidase (GO x ) to catalyze H 2 O...
The first unsymmetrical conjugated dendrimer was synthesized using a rather simple approach that involves only one synthon and two sets of reaction conditions. This shows broad absorption in the UV visible range possesses an intrinsic energy gradient from outside branches to core, naturally suggesting itself as potentially efficient light harvesting material.
CRISPR/Cas12a shows excellent potential in disease diagnostics. However, insensitive signal conversion strategies hindered its application detecting protein biomarkers. Here, we report a metal–organic framework (MOF)-based DNA bio-barcode integrated with the system for ultrasensitive detection of In this work, zirconium-based MOF nanoparticles were comodified antibodies and phosphorylated as an efficient converter, which not only recognized biomarker to form sandwich complex but also...
Near-infrared (NIR)-light-triggered nanomedicine, including photodynamic therapy (PDT) and photothermal (PTT), is growing an attractive approach for cancer due to its high spatiotemporal controllability minimal invasion, but the tumor eradication limited by intrinsic anti-stress response of cells. Herein, we fabricate a tumor-microenvironment responsive CRISPR nanoplatform based on oxygen-deficient titania (TiO