A5100764669- CRISPR and Genetic Engineering
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Genetics, Bioinformatics, and Biomedical Research
- Gene expression and cancer classification
- Advanced Memory and Neural Computing
- Advanced Nanomaterials in Catalysis
- bioluminescence and chemiluminescence research
- Extracellular vesicles in disease
- Bioinformatics and Genomic Networks
- Virus-based gene therapy research
- Machine Learning in Bioinformatics
Nanjing University
2019-2022
State Key Laboratory of Analytical Chemistry for Life Science
2021
Jilin Province Science and Technology Department
2021
Jilin University
2021
Shandong University of Science and Technology
2014
Remote-controlled manipulation of gene editing was achieved in vivo.
Near-infrared (NIR)-light-triggered photothermal therapy (PTT) is usually associated with undesirable damage to healthy organs nearby due the high temperatures (>50 °C) available for tumor ablation. Low-temperature PTT would therefore have tremendous value clinical application. Here, we construct a hypoxia-responsive gold nanorods (AuNRs)-based nanocomposite of CRISPR-Cas9 mild-photothermal via tumor-targeted gene editing. AuNRs are modified azobenzene-4,4'-dicarboxylic acid (p-AZO) achieve...
Manipulation of CRISPR delivery for stimuli-responsive gene editing is crucial cancer therapeutics through maximizing efficacy and minimizing side-effects. However, realizing controlled synergistic combination therapy remains a key challenge. Here, near-infrared (NIR) light-triggered thermo-responsive copper sulfide (CuS) multifunctional nanotherapeutic platform constructed to achieve release CRISPR-Cas9 ribonucleoprotein (RNP) doxorubicin tumor involving in therapy, mild-photothermal (PTT),...
Abstract Near‐infrared (NIR)‐light‐triggered photothermal therapy (PTT) is usually associated with undesirable damage to healthy organs nearby due the high temperatures (>50 °C) available for tumor ablation. Low‐temperature PTT would therefore have tremendous value clinical application. Here, we construct a hypoxia‐responsive gold nanorods (AuNRs)‐based nanocomposite of CRISPR‐Cas9 mild‐photothermal via tumor‐targeted gene editing. AuNRs are modified azobenzene‐4,4′‐dicarboxylic acid ( p...
Synergistic Therapy In article number 2101155, Yujun Song, Zhengbao Zha, Xin Han, and co-workers report a novel thermo-responsive nanotherapeutic platform, which is triggered by 808 nm near-infrared light irradiation. This exogenously controlled method can be used in combination tumor therapy, including gene-therapy, mild-photothermal chemotherapy, provides versatile strategy for gene editing drug release synergistic therapy with maximizing efficacy minimizing side-effects.