A5059865049- Animal Virus Infections Studies
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Animal Disease Management and Epidemiology
- Viral Infectious Diseases and Gene Expression in Insects
- interferon and immune responses
- Polymer Surface Interaction Studies
- Advanced biosensing and bioanalysis techniques
- Dendrimers and Hyperbranched Polymers
- Dental Health and Care Utilization
- Viral Infections and Immunology Research
- RNA Interference and Gene Delivery
- Orthodontics and Dentofacial Orthopedics
- Influenza Virus Research Studies
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Bone and Joint Diseases
- Bone health and osteoporosis research
- RNA regulation and disease
- Transgenic Plants and Applications
- Antimicrobial Peptides and Activities
- Ideological and Political Education
- Inflammasome and immune disorders
- Agriculture, Soil, Plant Science
- Nanoplatforms for cancer theranostics
Tianjin University
2019-2024
Wuhan University
2023
Harbin University
2016
Harbin Institute of Technology
2016
Anhui Medical University
2014
Shanxi Datong University
2014
Second Hospital of Anhui Medical University
2014
China University of Geosciences (Beijing)
2013
Porcine reproductive and respiratory syndrome virus (PRRSV) is a major economically devastating pathogen that has evolved various strategies to evade innate immunity. Downregulation of antiviral interferon largely contributes PRRSV immunoevasion through cytoplasmic melanoma differentiation-associated gene 5 (MDA5), receptor senses viral RNA. In this study, the downregulated transcription expression levels porcine MDA5 in infection were observed, but detailed mechanisms remain unclear. The...
Stabilized disc-like hybrid bicelles provide pH-sensitive release, preferable cellular uptake, tumor accumulation and therapeutic effect <italic>in vitro</italic> vivo</italic>.
The RNA helicase DDX39A plays an important role in the splicing/export process. In our study, human facilitated virus escape from innate immunity to promote proliferation by trapping TRAF3, TRAF6, and MAVS mRNAs HEK293T cell nucleus. was a target for SUMOylation. SUMO1, 2, 3 modifications were found on immunoprecipitated DDX39A. However, only SUMO1 modification decreased vesicular stomatitis virus-infected cells. Further studies have that viral infection reduced of enhanced its ability bind...
A safe, convenience, and effective vaccine for controlling avian influenza virus infection is crucial in scale poultry production. Yeasts are considered useful vehicles the delivery of antigens, which has been used to protect human animal health. We report here development H9N2 strain hemagglutinin (HA)-based recombinant protein vaccines (rH9HA) DNA-RNA-combined (rH9-DNA-RNA) Saccharomyces cerevisiae first time. The immunogenicity assay indicated that both rH9HA rH9-DNA-RNA could induce...
A recent study showed that patients with coronavirus disease 2019 (COVID-19) have gastrointestinal symptoms and intestinal flora dysbiosis. Yeast probiotics shape the gut microbiome improve immune homeostasis. In this study, an oral candidate of yeast-derived spike protein receptor-binding domain (RBD) fusion peptide displayed on surface yeast cell wall was generated. The toxicity efficacy administration were further performed in Institute Cancer Research (ICR) mice. No significant...
As transcriptional co-activator of AP-1/Jun, estrogen receptors and NF-κB, nuclear protein RBM39 also involves precursor mRNA (pre-mRNA) splicing. Porcine reproductive respiratory syndrome virus (PRRSV) causes sow disorders piglet diseases, which resulted in serious economic losses worldwide. In this study, the up-regulated expression down-regulated inflammatory cytokines (IFN-β, TNFα, IL-1β, IL-6) were determined PRRSV-infected 3D4/21 cells, accompanied with PRRSV proliferation. The roles...
Ubiquitination plays a major role in immune regulation after viral infection. An alternatively spliced porcine E3 ubiquitin ligase RNF122 promoted PRRSV infection and upregulated PRRSV-infected PAM cells was identified. We characterized the core promoter of RNF122, located between −550 to −470 bp upstream transcription start site (TSS), which displayed significant differential transcriptional activities regulating expression RNF122. The factor HLTF inhibited by nsp1α nsp7 PRRSV, E2F complex...
Porcine reproductive and respiratory syndrome virus (PRRSV) is a serious threat to the global swine industry. As typical immunosuppressive virus, PRRSV has developed variety of complex mechanisms escape host innate immunity. In this study, we uncovered novel immune mechanism infection. Here, demonstrate for first time that endoplasmic reticulum (ER)-resident N-acetyltransferase Nat9 an important restriction factor inhibited proliferation in acetyltransferase activity-dependent manner....
Prophylactic vaccination is regarded as the most effective means to control avian flu infection. Currently, there a need for universal vaccine that provides broad and long-lasting protection against influenza virus. Meanwhile, although yeast-based vaccines have been used in clinic, studies are still required further understand molecular mechanism of under physiological conditions.We generated hemagglutinin (HA) H5, H7 H9 using surface displaying technology evaluated protective efficacy...
To develop an appropriate Chinese version of the CLEFT-Q through translation and cultural adaptation to evaluate its reliability validity.
In order to protect the ecological environment of grasslands and improve people's livelihood, Chinese government proposed a policy called "Return Grazing Land Grassland".This is great strategy on construction grasslands.The has played very important role since was carried out in 2003.It significant about studying analyzing behaviors toward policy, summarizing positive negative aspects which promote or hinder putting forward some advices suggestions.
ABTRAST As transcriptional co-activator of AP-1/Jun, estrogen receptors and NF-κB, nuclear protein RBM39 also involves in precursor mRNA (pre-mRNA) splicing. Porcine reproductive respiratory syndrome virus (PRRSV) causes sow disorders piglet diseases, which resulted serious economic losses worldwide. In this study, the up-regulated expression down-regulated inflammatory cytokines (TNF, IL-1β) were determined PRRSV-infected 3D4/21 cells, accompanied with PRRSV proliferation. The roles...
Abstract The viral proliferation process of envelop viruses including invasion, assembly, and release is impacted by glycosylation. Sialic acid modification mainly exists in the terminal glycosylation proteins lipids. In this study, effect porcine sialylglycosyltransferase (ST3GAL2) on virus proliferation, as well regulation inflammatory factor PRRSV-infected 3D4/21 cell model were analyzed. expression ST3GAL2 was up-regulated cells. that promote PRRSV determined overexpression interference...