A5100679305- HIV/AIDS drug development and treatment
- Analytical Chemistry and Chromatography
- Drug Transport and Resistance Mechanisms
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Ginseng Biological Effects and Applications
- Monoclonal and Polyclonal Antibodies Research
- HIV Research and Treatment
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Traditional Chinese Medicine Analysis
- Genetics and Neurodevelopmental Disorders
- Antibiotics Pharmacokinetics and Efficacy
- RNA and protein synthesis mechanisms
- Natural product bioactivities and synthesis
- Computational Drug Discovery Methods
- Nanoparticle-Based Drug Delivery
- Analytical Methods in Pharmaceuticals
- CRISPR and Genetic Engineering
- Ion channel regulation and function
- DNA and Nucleic Acid Chemistry
- Neurofibromatosis and Schwannoma Cases
- Ocular Oncology and Treatments
- Chemotherapy-induced organ toxicity mitigation
- Pharmacogenetics and Drug Metabolism
South China University of Technology
2012-2025
Guangzhou Medical University
2025
Guangzhou First People's Hospital
2025
University of Leicester
2024
Central South University
2015-2024
Hunan Children's Hospital
2019-2024
Changchun University of Chinese Medicine
2017-2024
Insight (China)
2024
Nanyang Technological University
2024
Nanchang University
2024
Polygonum multiflorum (PM) is a well‐known Chinese herbal medicine that has been reported to induce inflammation‐associated idiosyncratic liver injury. This study aimed identify the genetic basis of susceptibility PM‐drug‐induced injury (PM‐DILI) and develop biological markers for predicting risk PM‐DILI in humans. The major histocompatibility complex (MHC) regions 11 patients with were sequenced, all human leukocyte antigen (HLA)–type frequencies compared Han‐MHC database. An independent...
<h3>Background</h3> High myopia, with the characteristic feature of refractive error, is one leading causes blindness worldwide. It has a high heritability, but only few causative genes have been identified and pathogenesis still unclear. <h3>Methods</h3> We used whole genome linkage exome sequencing to identify mutation in non-syndromic myopia family. Direct Sanger was screen candidate gene additional sporadic cases or probands. Immunofluorescence evaluate expression pattern process eye...
Abstract Autism spectrum disorder (ASD) describes a group of neurodevelopmental disorders with high heritability, although the underlying genetic determinants ASDs remain largely unknown. Large-scale whole-genome studies copy number variation in Han Chinese samples are still lacking. We performed genome-wide analysis 343 ASD trios, 203 patients sporadic cases and 988 controls population using Illumina genotyping platforms to identify CNVs related genes that may contribute risk. identified 32...
Myasthenia gravis (MG) is an autoimmune disorder caused by autoantibodies that target the neuromuscular junction, leading to muscle weakness and fatigability. Diagnosis based on clinical presentation, confirmation of presence AChR-Ab, characteristic electromyography findings, improvement after administration acetylcholinesterase inhibitors.MG often associated with thymoma other diseases, but it rare following allo-HSCT. we reports two cases MG transplantation, including first case...
<title>Abstract</title> Base editors, including cytosine base editor (CBE) and adenine editor, are widely used in plants to induce transitions. Recently, glycosylase (GBE) have been developed C-to-G transversions but within a narrow editing window human cells. Here, we describe six plant GBEs (GBE1-GBE6) composed of Cas9 nickase, APOBEC3A, Escherichia coli-derived uracil DNA N-glycosylase (eUNG), Arabidopsis thaliana-derived UNG (AtUNG). Our results illustrate that removing the inhibitor...
Adolescent idiopathic scoliosis exhibits high heritability and is one of the most common spinal deformities found in adolescent populations. However, little known about disease-causing genes families with exhibiting Mendelian inheritance.The aim this study was to identify causative gene a family scoliosis.Whole-exome sequencing performed on candidate gene. Sanger conducted validate mutations familial segregation. Real-time QPCR used measure expression level possible gene.We identified...
This article aims to compare and analyze the contents of ginsenosides in ginseng different plant ages from localities China.In this study, 77 fresh samples aged 2-4 years were collected 13 cultivation regions China. The content eight (Rg3, Rc, Rg1, Rf, Rb2, Rb1, Re, Rd) was determined using rapid resolution liquid chromatography coupled with quadrupole-time-of-flight tandem mass spectrometry (RRLC-Q-TOF MS/MS) comparatively evaluate influences region age.Ginsenoside differed significantly...
Abstract Benfotiamine is a lipid‐soluble thiamine precursor which can transform to in vivo and subsequently be metabolized monophosphate (TMP) diphosphate (TDP). This study investigated the pharmacokinetic profiles of its phosphorylated metabolites after single‐ multiple‐dose administration benfotiamine healthy Chinese volunteers, assessed bioavailability orally compared hydrochloride. In addition, concentration hippuric acid urine produced transformation process was determined. The results...
Abstract Background Congenital pseudarthrosis of the tibia (CPT) is a rare disease. Some patients present neurofibromatosis type 1 (NF1), while some others do not manifest NF1 (non-NF1). The etiology CPT, particularly non-NF1 well understood. Here we screened germline variants 75 CPT cases, including 55 and 20 non-NF1. Clinical data were classified analyzed based on gene variations to investigate genotype-phenotype relations two types patients. Results Using whole-exome sequencing Multiplex...
Cisplatin-based neoadjuvant chemotherapy has been shown to improve survival in patients with squamous cell carcinoma (SCC), but clinical biomarkers predict chemosensitivity remain elusive. Here, we show the long noncoding RNA (lncRNA) LINC01011, which termed cisplatin-sensitivity-associated lncRNA (CISAL), controls mitochondrial fission and cisplatin sensitivity by inhibiting BRCA1 transcription tongue SCC (TSCC) models. Mechanistically, found CISAL directly binds promoter forms an RNA-DNA...
SUMMARY Polyclonal anti-dsDNA and anti-ssDNA antibodies (PoAb) that showed significant binding to human umbilical vein endothelial cells (HUVEC) were isolated from eight patients with systemic lupus erythematosus (SLE). Anti-dsDNA PoAbs five seven demonstrated enhanced HUVEC during active disease, compared obtained corresponding remission. Reduction of the DNA content in PoAb preparations by DNase treatment was associated 20 32 tested, which included 75%‘active disease’ PoAbs, reduced three...
Abstract AMPD1 is an adenosine monophosphate deaminase that catalyzes the deamination of AMP to IMP. To understand physiological function AMPD1, we obtained a strain Ampd1 mutant mice from KOMP repository, which was generated by knockout-first strategy. An elevated level and almost complete lack IMP detected in skeletal muscle E18.5 tm1a/tm1a mice. However, died 2 days postnatally, contradicting previous reports. After removal cassette critical exon, homozygous for tm1c/tm1c tm1d/tm1d...
Abstract There are limited investigations on the role of feed additives in easing transition pullets to egg production phase. We investigated effects supplementation bacitracin methylene disalicylate (BMD) and select (myristic acid [MA], benzoic [BA], Aspergillus niger probiotic [PRO]) feeding program for from onset lay through 31 weeks age (woa). Parameters measured included hen-day (HDEP), intake (FI), conversion ratio (FCR), quality characteristics, ceca microbial activity, apparent...
Abstract BACKGROUND Our objective in this study was to evaluate the effectiveness of oligosaccharides extracted from black ginseng (OSBG), innovatively prepared by a low‐temperature steam‐heating process, improvement learning and memory impairment mice, as well mechanism(s). RESULTS Eight carbohydrates involving isomaltose maltotetraose were detected gensing; monosaccharide residues including mannose rhamnose also discovered. OSBG‐treated mice showed significant amelioration recognition...
Testosterone is a steroid hormone that plays an indispensable role in the normal metabolism of organisms. However, exogenous testosterone, even as low nmol L-1, will harm human body due to accumulation. In this study, we developed unlabeled fluorescent sensor for testosterone based on SYBR Green I. I dye can be embedded into G-quadruplex aptamer T5. The fluorescence quenching effect utilized achieve quantitative detection, which occurs by competition between and T5 binding sites. work,...
Abstract: Quantitative Structure-Property Relationship (QSPR) employs mathematical and statistical methods to reveal quantitative correlations between the pharmacokinetics of compounds their molecular structures, as well physical chemical properties. QSPR models have been widely applied in prediction drug absorption, distribution, metabolism, excretion, toxicity (ADMET). However, accuracy for predicting ADMET properties still needs improvement. Therefore, this paper comprehensively reviews...