A5012955951- Autoimmune Neurological Disorders and Treatments
- Epilepsy research and treatment
- Cellular transport and secretion
- Advanced Nanomaterials in Catalysis
- Pharmacological Effects and Toxicity Studies
- Electrochemical sensors and biosensors
- Neuroscience and Neuropharmacology Research
- Peripheral Neuropathies and Disorders
- Polyoxometalates: Synthesis and Applications
- Genetics and Neurodevelopmental Disorders
- Advanced biosensing and bioanalysis techniques
- Ion channel regulation and function
- RNA regulation and disease
- Metabolism, Diabetes, and Cancer
- MicroRNA in disease regulation
- Dye analysis and toxicity
- Metabolism and Genetic Disorders
- Nanocluster Synthesis and Applications
- Electrochemical Analysis and Applications
- Genetic Neurodegenerative Diseases
- TGF-β signaling in diseases
- Infectious Encephalopathies and Encephalitis
- Mitochondrial Function and Pathology
- Drug Transport and Resistance Mechanisms
- Cardiovascular Function and Risk Factors
Capital Medical University
2013-2023
Beijing Tian Tan Hospital
2010-2022
National Clinical Research Center for Digestive Diseases
2016-2022
Jilin University
2020-2022
Southwest Jiaotong University
2022
Jilin Medical University
2022
National Clinical Research
2020
Qilu Hospital of Shandong University
2007-2013
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2011
Peking Union Medical College Hospital
2009-2011
Wound healing greatly affects patients' health and produces medical burden. Therefore, we developed a multifunctional electrospun nanofiber dressing, which can inhibit methicillin-resistant Staphylococcus aureus (MRSA), drain excessive biofluid to promote wound healing, simultaneously monitor pH level. The polyoxometalate (α-K6P2W18O62·14H2O, P2W18) oxacillin (OXA) are encapsulated in hydrophobic polylactide (PLA) synergistically MRSA. phenol red (PSP) is hydrophilic polyacrylonitrile (PAN)...
To assess the impact of childhood epilepsy on parental quality life (QOL) and psychological health, to investigate possible correlations between QOL background variables as well anxiety depression.Parents having an epileptic child (n = 263) parents a healthy 270) were enrolled. Groups in balance for variables. Short-Form Health Survey (SF-36) Questionnaire, Zung Depression Scale (ZDS) Anxiety (ZAS) applied all parents. Patients divided into first visit group (newly diagnosed epilepsy)...
Oxidative stress is related to many diseases, but available clinical treatment methods are currently limited. Exploitation of enzyme-mimicking nanomaterials (nanozymes) a promising way for scavenging reactive oxygen species (ROS) and ROS-related diseases. Herein, the catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) mimicking activities expressed by MnO2 nanoparticles (MnO2-BSA NPs) coated with BSA. Effective •OH removal activity also MnO2-BSA NPs at neutral pH....
Some recent studies suggest that some imaging-negative temporal lobe epilepsy (TLE) had significant amygdala enlargement (AE). Contradictory data were also reported in previous regarding the association between AE and TLE. The present study was to investigate clinical characters of a group TLE with compare volume same patient before after antiepileptic drugs treatment by larger sample size.This recruited 33 mesial patients 35 healthy volunteers. history, seizure semiology,...
Objective: Anti-GABA-B (gamma aminobutyric acid-B) receptor encephalitis is an autoimmune disease mediated by GABA-B-related antibodies. To fully understand the disease, we collected clinical data from patients with GABA-B and conducted analysis to draw conclusions. Methods: All Neurology Department of Beijing Tiantan Hospital, affiliated Capital Medical University, August 2015 September 2019 were accepted as study subjects. The analyzed retrospectively included general demographic...
Purpose: The metabolic patterns of 18F-fluoro-2-deoxy-d-glucose positron emission tomography (18F-FDG-PET) in autoimmune encephalitis associated with leucine-rich glioma-inactivated 1 antibody (LGI1 AE) are still unclear. We performed a cohort study to investigate the clinical characteristics and diagnostic value based on 18F-FDG-PET patients LGI1 AE. Materials Methods: A total 34 including 18 (53%) acute phase 16 (47%) chronic who were diagnosed AE retrospectively analyzed from October 2014...
The catalytic properties of bimetallic nanoparticles have been widely studied by researchers in many fields. In this paper, core-shell Cu/Au (Cu/Au NPs) were synthesized a simple and mild one-pot method, their peroxidase activity was proved catalyzing the oxidation 3,3',5,5'-tetramethylbenzidine (TMB) with color change to blue. solution absorbance strongly depends on concentration H2O2, so it can be used for direct detection H2O2 indirect glucose. What's more, GSH efficiently react hydroxyl...
Increasing evidence indicates that neuroinflammation plays a crucial role in the pathogenesis of temporal lobe epilepsy (TLE). However, it is unclear how perpetuate inflammation develops. Some recent studies have suggested possible involvement microRNA-146a (miR-146a) modulation inflammatory signaling occurring TLE. To understand miR-146a modulates TLE, we investigated interleukin-1β (IL-1β), and human complement factor H (CFH) rat models chronic TLE U251 cells. We found enhancive could...
Abstract Objective The purpose of this study is to analyze the seizure semiologic characteristics patients with autoimmune epilepsy ( AE ) and describe investigation using a larger sample size. Methods This observational retrospective case series was conducted from tertiary center between May 2014 March 2017. Cases new‐onset seizures were selected based on laboratory evidence autoimmunity. At same time, typical mesial temporal lobe MTLE hippocampal sclerosis HS recruited as control group...
Objective To summarize the clinical features and 18 F-fluorodeoxy-glucose positron emission tomography ( F-FDG-PET) patterns of absence status epilepsy (ASE). Methods In our study, three patients with ASE were presented, a comprehensive review relevant literature was conducted to elucidate PET results ASE. Results Seventeen cases from 7 articles identified. A total 20 included in this including 9 males (9/20) 11 females (11/20). The average age at onset 28.1 ± 15.07 years. Patients typically...
Background: This study aimed to analyze the clinical characteristics of anti-leucine-rich glioma-inactivated protein 1 (LGI1) encephalitis patients and investigate prognostic factors by using a large-sample long-term follow-up cohort. Methods: The data 45 (29 males; mean age, 57.0 years) from May 2014 August 2019 were collected. All followed up face-to-face interviews in third month after discharge then telephone and/or every 6 months until November 2020. We evaluated each patient's response...
Objective: The purpose of this study is to evaluate the potential diagnostic benefit SPM-based semi-quantitative FDG-PET analysis in autoimmune encephalitis (AE) compared with visual by experienced neuroradiologists using a larger sample size. Methods: This observational retrospective case series was conducted from tertiary epilepsy center between May 2014 and March 2017. Healthy individuals without any neurologic or psychiatric diseases were recruited as control. We determined brain...
Brain 18F-fluorodeoxyglucose positron emission tomography (FDG PET) is a sensitive technique for assisting in the diagnosis of patients with anti-leucine-rich glioma-inactivated 1 (LGI1) antibody encephalitis. However, common pattern this disorder assessed by FDG PET remains unknown. The present study aimed to explore glucose metabolic patterns based on voxel analysis.This retrospective enrolled 25 anti-LGI1 encephalitis, who were admitted Beijing Tiantan Hospital between September 2014 and...
To identify factors affecting the development of drug-resistant epilepsy (DRE), and establish a reliable nomogram to predict DRE in post-traumatic (PTE) patients.This study conducted retrospective clinical analysis patients with PTE who visited Epilepsy Center, Beijing Tiantan Hospital from January 2013 December 2018. All participants were followed up for at least 3 years, was assessed. Data 2017 used as dataset model building. Those independent predictors included final multivariable...