A5102019770- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- RNA regulation and disease
- Heavy Metal Exposure and Toxicity
- Plant Genetic and Mutation Studies
- Healthcare and Venom Research
- Exercise and Physiological Responses
- Effects of Radiation Exposure
- Wastewater Treatment and Reuse
- RNA modifications and cancer
- Planetary Science and Exploration
- Wireless Body Area Networks
- Trace Elements in Health
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Agriculture, Soil, Plant Science
- Cytokine Signaling Pathways and Interactions
- Plant Micronutrient Interactions and Effects
- Genomics and Phylogenetic Studies
- Molecular Biology Techniques and Applications
- Psychological and Temporal Perspectives Research
- Advanced oxidation water treatment
- Plant Stress Responses and Tolerance
University of Chinese Academy of Sciences
2021-2024
Dalian Institute of Chemical Physics
2023
Dalian Jiaotong University
2023
Chinese Academy of Sciences
2011-2023
Institute of Modern Physics
2008-2023
Shenzhen Nanshan Center for Chronic Disease Control
2017
Ningbo University
2017
Kunming Medical University
2017
Lanzhou University
2012
Radiation-induced bystander effects are well-established phenomena, in which DNA damage responses induced not only the directly irradiated cells but also non-irradiated through intercellular signal transmission. Recent studies hint that possibly mediated via small non-coding RNAs, especially microRNAs. Thus, more details about roles of microRNA urgently needed to be elucidated. Here we demonstrated were human fetal lung MRC-5 fibroblasts medium-mediated way by different types radiation. We...
Glutamine metabolism provides energy to tumor cells and also produces reactive oxygen species (ROS). Excessive accumulation of ROS can damage mitochondria eventually lead cell death. xCT (SLC7A11) is responsible for the synthesis glutathione in order neutralize ROS. In addition, mitophagy remove damaged keep alive. Ionizing radiation kills by causing ROS, which subsequently induces nuclear DNA damage. With this mind, we explored mechanism intracellular induced ionizing hypothesized new...
OBJECTIVES:The aim of this study was to compare the expression levels serum miRNAs in diabetic retinopathy and type 2 diabetes mellitus.METHODS: Serum miRNA profiles from cases (type mellitus patients with retinopathy) controls without were examined by miRNA-specific microarray analysis.Quantitative real-time polymerase chain reaction used validate significantly differentially expressed analysis 45 age-, sex-, body mass index-and duration-of-diabetes-matched controls.The relative changes...
microRNAs (miRNAs) play a crucial role in mediation of the cellular sensitivity to ionizing radiation (IR). Previous studies revealed that miR-300 was involved response IR or chemotherapy drug. However, whether could regulate DNA damage responses induced by extrinsic genotoxic stress human lung cancer and underlying mechanism remain unknown. In this study, expression examined cells treated with IR, effects on repair, cell cycle arrest, apoptosis senescence were investigated. It found...
Alterations in microRNA (miRNA) expression have been observed cells subjected to exogenous stresses, implying that miRNAs play an important role cellular stress response; however, the underlying mechanism is still largely unknown. In present study, we found miR-3928 was implicated response ionizing radiation. After exposed X-rays, increased 1.5 h and then decreased, meanwhile Dicer, a key component miRNA processing machinery, gradually. An oscillation of both mature Dicer mRNA from 2 3.5...
Up to now, more than 1048 human miRNAs have been identified. However, the recognition of new is becoming and difficult. Based on hypothesis that expression some can be induced by ionizing radiation, total RNAs HeLa cells were isolated 1 h after exposure 2 Gy X-rays, small enriched sequenced PAGE Solexa technology, respectively. As a result, 421 kinds known 337 unknown sequences identified, among which 10 novel characterized bioinformatic approach verified qRT-PCR. Finally, putative targets...
Ionizing radiation in space, devices or nuclear disasters are major threats to human health and public security. Expanding countermeasures for dealing with accidental occupational exposure is crucial the protection of injuries. Circulating microRNAs (miRNAs) have emerged as promising biomarkers recent years. However, origin, distribution functions radiosensitive circulating miRNAs remain unclear, which obstructs their clinical applications future. In this study, we found that mmu-miR-342-3p...
<title>Abstract</title> Circadian rhythms are highly conserved in virtually all organisms. They regulate numerous biological functions and keep them synchronized with alterations the external environment. Environmental factors such as light, temperature microgravity have been shown to affect circadian rhythms, but impact of ionizing radiation (IR) on rhythm is still elusive. Here, transcription translation key genes, <italic>per</italic>, <italic>clock</italic>, <italic>cry</italic>...
MicroRNAs (miRNAs) play important roles in the regulation of cellular stress responses.We previously uncovered 10 novel human miRNAs which are induced by X-ray irradiation HeLa cells using Solexa deep sequencing.The most highly expressed new miRNA, miR-5094, was predicted to target STAT5b.This study wonders whether miR-5094 participates radiation response via STAT5b.Firstly, direct interaction between miRNA-5094 and STAT5b 3'-UTR confirmed luciferase reporter assay.Then, responsive...
Abstract MicroRNAs (miRNAs) are non-coding RNAs of 19-22 nucleotides which regulate a diverse set physiological processes including immune cell development by post-transcriptional gene regulation. Circulating miRNAs in blood have been assessed as biomarkers disease diagnosis and capable modulating wide-range biological functions through targeting the molecules recipient cells. In our previous work, some radiosensitive circulating identified, most them were closely associated with...
Abstract MicroRNAs (miRNAs) are highly conserved small non-coding RNAs that alter protein expression and regulate multiple intracellular processes including cellular stress response. We previously uncovered several novel miRNAs, whose expressions induced by X-rays irradiation in HeLa cells, using a miRNA array. Here, we examined the function of miR-5094 during radiation With software predictions confirmatory experiments, identified signal transduction activator transcription 5b (STAT5b),...