A5046348283- Liver Disease Diagnosis and Treatment
- Platelet Disorders and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- HIV Research and Treatment
- Hematopoietic Stem Cell Transplantation
- HIV/AIDS Research and Interventions
- Acute Myeloid Leukemia Research
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease and Transplantation
- Cytomegalovirus and herpesvirus research
- Glycosylation and Glycoproteins Research
- HIV/AIDS drug development and treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- Gut microbiota and health
- Neutropenia and Cancer Infections
- Acute Lymphoblastic Leukemia research
- HIV-related health complications and treatments
- Lipid metabolism and disorders
- Tuberculosis Research and Epidemiology
- Diabetic Foot Ulcer Assessment and Management
- Additive Manufacturing and 3D Printing Technologies
- Chronic Lymphocytic Leukemia Research
- Radiomics and Machine Learning in Medical Imaging
Guangxi Medical University
2023-2025
First Affiliated Hospital of GuangXi Medical University
2023-2025
Peking University
2004-2024
Peking University People's Hospital
2018-2024
National Clinical Research Center for Digestive Diseases
2020-2024
Taihe Hospital
2019-2024
Southern University of Science and Technology
2024
University of Hong Kong
2024
Taixing People's Hospital
2024
Hubei University of Medicine
2019-2024
To develop ultrasound-based radiomics models and a clinical model associated with inflammatory markers for predicting intrahepatic cholangiocarcinoma (ICC) lymph node (LN) metastasis. Both are integrated enhanced preoperative prediction. This study retrospectively enrolled 156 surgically diagnosed ICC patients. A region of interest (ROI) was manually identified on the ultrasound image tumor to extract features. In training cohort, we performed Wilcoxon test screen differentially expressed...
Hepatocellular carcinoma (HCC) is high heterogeneity and remains an unmet medical challenge, but their metabolic has not been fully uncovered required clinical applicable translational strategies. By analyzing the RNA sequencing data in in-house cohort public HCC cohorts, we identified a subtype of associated with multi-omics features prognosis. Multi-omics alterations clinicopathological information between different subtypes were analyzed. Gene signature, radiomics, contrast-enhanced...
Abstract Background Albuvirtide is a once-weekly injectable human immunodeficiency virus (HIV)-1 fusion inhibitor. We present interim data for phase 3 trial assessing the safety and efficacy of albuvirtide plus lopinavir-ritonavir in HIV-1-infected adults already treated with antiretroviral drugs. Methods carried out 48-week, randomized, controlled, open-label non-inferiority at 12 sites China. Adults on World Health Organization (WHO)-recommended first-line treatment >6 months plasma...
Background. The aim of this study was to describe 3-year mortality rates, associated risk factors, and long-term clinical outcomes children enrolled in China's national free pediatric antiretroviral therapy (ART) program. Methods. Records were abstracted from the human immunodeficiency virus (HIV)/AIDS case reporting ART databases for all HIV-positive ≤15 years old who initiated prior December 2010. Mortality factors over 3 follow-up examined using Cox proportional hazards regression models....
Few data are available on the outcomes of pediatric antiretroviral therapy (ART) in developing world.Eighty-three children were followed prospectively China from July 2005 to August 2006 and received (zidovudine or stavudine) plus lamivudine (nevirapine efavirenz).Fifty-one ART naive at enrollment, 32 experienced. After 12 months, median weight increased by 0.3 for age z-score, CD4 count 116 340 cells/mm (P < 0.0001), viral load decreased 5.53 <2.60 log10 copies/mL 0.0001) previously...
Heart failure (HF) is a disease with high morbidity and mortality. In patients HF, decreased cardiac output blood redistribution results in intestinal perfusion destruction of barrier. Microorganisms endotoxins can migrate into the circulation, aggravating systemic inflammation HF. Trimethylamine N-oxide (TMAO) highly closed to occurrence However, exact mechanism between TMAO HF remains unclear.To investigate role transverse-tubule (T-tubule) cultured cardiomyocytes.T-tubule imaging analysis...
Objectives The present study aimed to determine the feasibility of American College Radiology's (ACR) contrast‐enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System (LI‐RADS) (version 2017) in examinations using Sonazoid compare its diagnostic performance with that modified LI‐RADS patients at high risk hepatocellular carcinoma (HCC). Methods This retrospective study's sample population consisted 137 participants a total 140 nodules who underwent CEUS pathological confirmation...
Gastric cancer is the fourth most common malignant worldwide. Important for tumorigenesis and progression, aberrant glycosylation occurs frequently in cancers. We investigated differences O-glycosylation serum of 157 gastric patients (GC) 144 healthy donors.We used method labeling O-glycans (released from proteins) with 1-phenyl-3-methyl-5-pyrazolone followed by LC-MS analysis. Analyzing data partial least squares discriminant unpaired Student t test, combined structural information LC-MS/MS...
Abstract Objectives Hepatitis B virus X (HBx) is closely associated with HBV‐related hepatocarcinogenesis via the inactivation of tumour suppressors. Protein phosphatase 2A (PP2A) regulatory subunit B56 gamma (B56γ), as a suppressor, plays critical role in regulating cellular phosphorylation signals dephosphorylation signalling proteins. However, underlying mechanism that B56γ involved HBx‐associated phenotypes and mediating anti‐HBx antibody‐mediated suppression remains unknown. Materials...
Objective To assess the diagnostic performance of contrast‐enhanced ultrasound liver imaging reporting and data system (CEUS LI‐RADS) version 2017 for small hepatic lesions ≤3 cm before after changing LR‐M criteria. Methods We retrospectively analyzed CEUS examination 179 patients who were at high risk hepatocellular carcinoma (HCC) with focal (194 in total) evaluated capability American College Radiology modified LI‐RADS algorithms. Results Revision early washout time to 45 seconds...
Incomplete thermal ablation (ITA) fosters the malignancy of residual cells in Hepatocellular carcinoma (HCC) with unclear mechanisms now. This study aims to investigate expression changes NDST2 following ITA HCC and its impact on cancer cells.
Abstract Thermal management of high-power electronics is often a major obstacle in achieving improved packaging density. Emergence SiC devices allows higher voltage and temperature limits, but thermal still bottleneck compact, reliable high-performance systems. This study introduces the design an advanced configuration dual-active-bridge 10 kW DC-DC converter module with 97% efficiency ∼1.5 × 104 kW/m3 power density based on preliminary modeling analysis. The proposed scheme for significant...
Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic stem cell malignancy, and allogeneic transplantation (allo-HSCT) the only curable treatment. The outcomes after transplant are influenced by both disease characteristics patient comorbidities. To develop novel prognostic model to predict post-transplant survival of CMML patients, we identified risk factors applying univariable multivariable Cox proportional hazards regression derivation cohort. In analysis, advanced age (hazard...
The prevalence of HIV/AIDS and tuberculosis (TB) within mainland China is unprecedented the convergence these two infectious diseases increasingly significantly endangering human health for socioeconomic development. To date, clinical manifestations, laboratory presentation, epidemiologic features HIV/TB coinfection cases in have not been described detail. assess incidence, characteristics outcome with HIV TB, we conducted a cross-sectional study coinfected reported from nine domestic...