A5047589359- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV-related health complications and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV, Drug Use, Sexual Risk
- Adolescent Sexual and Reproductive Health
- Lymphoma Diagnosis and Treatment
- Polyomavirus and related diseases
- Viral-associated cancers and disorders
- Syphilis Diagnosis and Treatment
- Mental Health Treatment and Access
- Mycobacterium research and diagnosis
- Hepatitis B Virus Studies
- Family Caregiving in Mental Illness
- Tuberculosis Research and Epidemiology
- Radiomics and Machine Learning in Medical Imaging
- Pancreatitis Pathology and Treatment
- Herpesvirus Infections and Treatments
- LGBTQ Health, Identity, and Policy
- Temporomandibular Joint Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- HIV/AIDS oral health manifestations
- Slime Mold and Myxomycetes Research
- COVID-19 Impact on Reproduction
Capital Medical University
2016-2025
Beijing Ditan Hospital
2016-2025
Hefei Institutes of Physical Science
2024
High Magnetic Field Laboratory
2024
Chinese Academy of Sciences
2024
Qufu Normal University
2024
Third Affiliated Hospital of Harbin Medical University
2021-2023
Harbin Medical University
2021-2023
China Geological Survey
2023
Peking University
2022
The administration of COVID-19 vaccines is the primary strategy used to prevent further infections by COVID-19, especially in people living with HIV (PLWH), who are at increased risk for severe symptoms and mortality. However, vaccine hesitancy, safety, immunogenicity among PLWH have not been fully characterized. We estimated hesitancy status vaccination Chinese PLWH, explored safety impact on antiviral therapy (ART) efficacy compared an inactivated between healthy controls (HC). In total,...
BackgroundTherapeutic approaches to HIV-suppressed immunological non-responders (INRs) remain unsettled. We previously reported efficacy of Chinese herbal Tripterygium wilfordii Hook F in INRs. Its derivative (5R)-5-hydroxytriptolide (LLDT-8) on CD4 T cell recovery was assessed.MethodsThe phase II, double-blind, randomized, placebo-controlled trial conducted adults patients with long-term suppressed HIV infection and suboptimal recovery, at nine hospitals China. The were 1:1:1 assigned...
Background Dolutegravir/lamivudine (DTG/3TC) is a recommended therapy regimen for hepatitis B surface antigen (HBsAg)-negative people living with HIV (PLWH) who have achieved virological suppression or are treatment-naïve. However, this may overlook the impact of occult infection on suppression, which mainly present as core antibody (HBcAb) positive but HBsAg negative. We aim to assess effect HBcAb positivity among PLWH had switched DTG/3TC.
Recent years have witnessed unprecedented strides in comprehending non-CD4 regulatory T cells (Tregs), such as CD8+ Tregs and double negative (DNT cells), their role sustaining immune tolerance restricting activation. This study investigates the of Foxp3+CD8+ during HIV infection assess markers associated with CD4+ Tregs. was designed a cross-sectional cohort study, comprising 21 age-matched healthy controls (HCs), 122 treatment-naïve participants (TNs), 60 people living (PLWH) receiving...
In this qualitative study, 29 HIV-positive, Chinese patients reported highly favorable impressions of their healthcare providers, who were seen as providing important medical-related, financial, and emotional support. Generally, the patient-provider relationship positively impacted participants ability to maintain health was especially critical when isolated from familial sources support due intense AIDS stigma. Often family members informed an HIV diagnosis before patient, revealing...
Mitochondrial dysfunction has frequently been found in HIV-infected patients regardless of whether they received antiretroviral therapy (ART). Accumulating evidence suggests that exhibit marked changes mitochondrial membrane potential (MMP), reactive oxygen species (ROS) accumulation, adenosine triphosphate generation, mass (MM), DNA, etc. However, toxicity CD4T and CD8T cells caused by different levels HIV progression ART is poorly understood.Blood samples were obtained from 97 ART-naïve...
Abstract International health experts agree that China is on the verge of an AIDS crisis. In response, Chinese government initiated “Four Frees and One Care” policy in 2003 to decrease economic barriers increase access antiretroviral therapies for people with HIV. However, long-term treatment success requires not only access, but high rates medication adherence. This qualitative interview study 29 persons receiving HIV care at Beijing's Ditan Hospital identified facilitators The interviews...
Few data are available on the outcomes of pediatric antiretroviral therapy (ART) in developing world.Eighty-three children were followed prospectively China from July 2005 to August 2006 and received (zidovudine or stavudine) plus lamivudine (nevirapine efavirenz).Fifty-one ART naive at enrollment, 32 experienced. After 12 months, median weight increased by 0.3 for age z-score, CD4 count 116 340 cells/mm (P < 0.0001), viral load decreased 5.53 <2.60 log10 copies/mL 0.0001) previously...
Cancer is responsible for elevated HIV-related morbidity and mortality. Research on HIV-infected patients with concurrent cancer rare in China. The purpose of our study was to investigate the prevalence risk factors associated among inpatients Beijing, mortality cancer. Hospital records from a total 1946 were collected Beijing Ditan Hospital. data, 2008 2013, retrospectively. diagnoses included AIDS-defining cancers (ADC) non-AIDS defining (NADC). Logistic regression used identify predicting...
Objective The study aimed to use supervised machine learning models predict the length and risk of prolonged hospitalization in PLWHs help physicians timely clinical intervention avoid waste health resources. Methods Regression were established based on RF, KNN, SVM, XGB hospital stay using RMSE, MAE, MAPE, R 2 , while classification NN, accuracy, PPV, NPV, specificity, sensitivity, kappa, visualization evaluation AUROC, AUPRC, calibration curves decision all used for internally validation....
chen w.‐t., shiu c.‐s., simoni j., fredriksen‐goldsen k., zhang f. & zhao h. (2010) Optimizing HIV care by expanding the nursing role: patient and provider perspectives. Journal of Advanced Nursing 66 (2), 260–268. Abstract Title. Aim. This paper is a report study conducted to explore healthcare services from perspectives both providers patients in order understand how optimize care. Background. In China, usually first diagnose general hospital. Then, HIV‐positive individuals are...
Transmitted drug resistance (TDR) is a critical ongoing public health challenge in HIV/AIDS therapy. We explore the prevalence of TDR, its patterns, associated risk factors, and predicted sensitivity Beijing between 2015 2018.Retrospective data on TDR from 3265 antiretroviral therapy (ART)-naïve patients were collected at Ditan Hospital 1 August 2014 to 31 July 2018. was defined according Stanford Drug Resistance Mutations Database. prevalence, pattern, analysed.The overall HIV-1 6.68% (218...
Background The introduction of antiretroviral therapy (ART) has resulted in marked reductions morbidity among people living with HIV (PLWH). Monitoring the hospitalizations PLWH is important evaluating quality healthcare and forecasting co-morbidity pattern. We aimed to describe trends rates causes hospitalization who initiated ART an HIV-designated hospital China. Methods were hospitalized Beijing Ditan Hospital from 2008 2020 selected for study. Hospitalizations classified based on...
Abstract Background Efavirenz (EFV)-induced neuropsychiatric toxicity bothers people living with HIV (PLHIV). Neuropsychiatric adverse effects of EFV may differ by length time on EFV-based antiretroviral treatment (ART). Methods A cross-sectional, single-center study was conducted at Beijing Ditan Hospital in China from June–August 2020 among ART-experienced PLHIV who were long-term ART. 424 eligible virological suppressed participants enrolled and divided into four groups according to ART:...
Science and technology innovation is the kernel of developing new quality productivity, finance has an important role in promoting science innovation. Based on this, this paper studies path financial boosting innovation, selects national panel data from 2013 to 2022, adopts entropy value method determine weight each index calculate comprehensive value, establishes VAR model input development. It found that 35% changes development can be explained by inputs, further puts forward suggestions...
China is experiencing a rapid increase in the number of HIV-infected women. In this study, we describe development and preliminary evaluation an intervention tailored for Chinese women caregivers to improve their self- family management, with goals enhancing physical quality life (QOL) decreasing depressive symptomatology. Forty-one were recruited from two premier hospitals July 2014 through March 2016. Participants randomized either control or arm Self- Family Management Intervention...
Abnormal cervical cytology is commonly observed in women with human immunodeficiency virus (WWH).
This study explored the pathogenesis of human immunodeficiency virus (HIV) and monkeypox co-infection, identifying candidate hub genes potential drugs using bioinformatics machine learning. Datasets for HIV (GSE 37250) 24125) were obtained from GEO database. Common differentially expressed (DEGs) in co-infection identified by intersecting DEGs datasets with key modules screened Weighted Gene Co-Expression Network Analysis (WGCNA). After gene ontology (GO) Kyoto Encyclopedia Genes Genomes...
In China, the social stigma of both substance use and HIV remains major barriers. HIV+ individuals have been demonstrated to higher psychosocial distress in literature. To ensure quality life among Chinese individuals, self-efficacy HIV-related management including anxiety is key suppress viral load maintain healthy lives.We examine mediation relationship use, anxiety, self-management efficacy.A cross-sectional study design was used. 137 were recruited from two premier hospitals: Beijing's...