A5071217303- Cellular Mechanics and Interactions
- Cell Adhesion Molecules Research
- Wnt/β-catenin signaling in development and cancer
- Renal and related cancers
- Ion Transport and Channel Regulation
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Skin and Cellular Biology Research
- Microtubule and mitosis dynamics
- Protease and Inhibitor Mechanisms
- Protein Kinase Regulation and GTPase Signaling
- Tissue Engineering and Regenerative Medicine
- Wound Healing and Treatments
- Cell death mechanisms and regulation
- Genetic and Kidney Cyst Diseases
- Ubiquitin and proteasome pathways
- Dermatologic Treatments and Research
- Autophagy in Disease and Therapy
- Force Microscopy Techniques and Applications
- Chronic Kidney Disease and Diabetes
- Epigenetics and DNA Methylation
- Erythrocyte Function and Pathophysiology
- Ion Channels and Receptors
- Tendon Structure and Treatment
First People's Hospital of Chongqing
2025
National Cheng Kung University
2015-2024
First People's Hospital of Yunnan Province
2010-2023
Kunming University of Science and Technology
2022-2023
The University of Texas MD Anderson Cancer Center
2016-2023
Robert Bosch (Germany)
2023
L3S Research Center
2022
Leibniz University Hannover
2022
Medizinische Hochschule Hannover
2022
Second People’s Hospital of Yibin
2022
// Ching-Yi Liu 1,2 , Hsi-Hui Lin 2 Ming-Jer Tang and Yang-Kao Wang 1,3,4 1 Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan Department Physiology, 3 Cell Biology Anatomy, 4 Center Neurotrauma Neuroregeneration, Taipei Taipei, Correspondence to: Wang, email: Tang, Keywords : vimentin, epithelial-mesenchymal transition (EMT), microtubule, focal adhesions, cell stiffness Received November 11, 2014 Accepted March 30, 2015 Published April 18, Abstract...
Store-operated Ca 2+ entry (SOCE) is the principal mechanism in nonexcitable cells. Stromal-interaction molecule 1 (STIM1) an endoplasmic reticulum sensor that triggers SOCE activation. However, role of STIM1 regulating cancer progression remains controversial and its clinical relevance unclear. Here we show STIM1-dependent signaling important for cervical cell proliferation, migration, angiogenesis. overexpression tumor tissue noted 71% cases early-stage cancer. In tissues, level expression...
Abstract Purpose: Acquisition of epithelial-mesenchymal transition (EMT) by primary carcinoma cells is associated with disrupted epithelial integrity, local invasion, and ultimately metastasis. Little known about the existence function EMT in cervical cancer. This study aims to investigate regulation squamous cell carcinoma. Experimental Design: We investigated molecular events surgical specimens, which present progression Two cancer lines culture normal epithelia were used regulatory...
// Hsi-Hui Lin 1* , Hsiu-Kuan 2* I-Hsuan 1 Yu-Wei Chiou 3 Horn-Wei Chen Ching-Yi Liu 2 Hans I-Chen Harn Wen-Tai Chiu Yang-Kao Wang 4 Meng-Ru Shen 5 and Ming-Jer Tang 1,2 Department of Physiology, National Cheng Kung University, Tainan, Taiwan Institute Basic Medical Sciences, Biomedical Engineering, Cell Biology Anatomy, Pharmacology, * These authors have contributed equally to this work Correspondence to: Tang, email: Keywords : matrix stiffness, mechanical phenotype, stiffness sensing,...
An intramyocardial microenvironment was created using nanofibers and VEGF for endogenous cardiac repair after infarction.
Focal adhesion (FA) assembly, mediated by integrin activation, responds to matrix stiffness; however, the underlying mechanisms are unclear. Here, we showed that β1 and caveolin-1 (Cav1) levels were decreased with declining stiffness. Soft selectively downregulated endocytosis subsequent lysosomal degradation. Disruption of lipid rafts methyl-β-cyclodextrin or nystatin, knockdown Cav1 siRNA cell spreading, FA protein in cells cultured on stiff matrix. Overexpression Cav1, particularly...
Abstract Tissue regeneration is a process that recapitulates and restores organ structure function. Although previous studies have demonstrated wound-induced hair neogenesis (WIHN) in laboratory mice ( Mus ), the limited to center of wound unlike those observed African spiny Acomys ) mice. mechanics been implicated as an integral part tissue morphogenesis. Here, we use WIHN model investigate mechanical molecular responses mice, report these models demonstrate opposing trends spatiotemporal...
Collagen is an important material for biomedical research, but using mammalian tissue-derived collagen carries the risk of zoonotic disease transmission. Marine organisms, such as farmed tilapia, have emerged a safe alternative source research. However, tilapia products research are rare, and their biological functions remain largely unexamined. In this study, we characterized commercial skin SDS-PAGE fibril formation assays evaluated its effects on fibroblast adhesion, proliferation,...
Embryonic development requires cell migration in response to positional cues. Yet, how groups of cells recognize and translate information into morphogenetic movement remains poorly understood. In the developing kidney, ureteric bud epithelium grows from nephric duct towards a group posterior intermediate mesodermal cells, metanephric mesenchyme, induces formation adult kidney. The secreted protein GDNF its receptor RET are required for outgrowth subsequent branching. However, it is unclear...
One potential mechanism through which obesity exerts adverse effects on the vascular system is by increasing aortic stiffness, a change known to be predictive of increased cardiovascular mortality. The aim this study was investigate pathophysiology that links stiffening.Obese (ob/ob) mice were used examine physical, morphological, and molecular changes in aorta response obesity. ob/ob had pulse wave velocity tissue rigidity. exhibited decreases lysyl oxidase (LOX) activity cross-linked...