A5108833689- Immune cells in cancer
- Tryptophan and brain disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Gut microbiota and health
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- Immune Cell Function and Interaction
- Colorectal Cancer Treatments and Studies
- Pancreatic function and diabetes
- Nanoparticle-Based Drug Delivery
- Cytokine Signaling Pathways and Interactions
- Cellular Mechanics and Interactions
- Cancer Mechanisms and Therapy
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Monoclonal and Polyclonal Antibodies Research
- Biochemical and Molecular Research
- Immunotoxicology and immune responses
Sichuan University
2025
West China Hospital of Sichuan University
2025
Anhui Medical University
2013-2024
First Affiliated Hospital of Anhui Medical University
2024
University of Notre Dame
2024
The University of Texas MD Anderson Cancer Center
2017-2022
Shandong University
2021
Jinan Central Hospital
2021
Shandong First Medical University
2021
Harbin University of Commerce
2021
The role of immune responses in tumor development is a central issue for biology and immunology. IL-17 an important cytokine inflammatory autoimmune diseases. Although IL-17-producing cells are detected cancer patients tumor-bearing mice, the controversial, mechanisms remain to be fully elucidated. In current study, we found that tumors was inhibited IL-17R-deficient mice. A defect IFN-gammaR increased growth, whereas growth mice were deficient both IL-17R compared with wild-type animals....
Abstract A hallmark of pancreatic ductal adenocarcinoma (PDAC) is an exuberant stroma comprised diverse cell types that enable or suppress tumor progression. Here, we explored the role oncogenic KRAS in protumorigenic signaling interactions between cancer cells and host cells. We show mutation (KRAS*) drives cell-autonomous expression type I cytokine receptor complexes (IL2rγ–IL4rα IL2rγ–IL13rα1) turn are capable receiving growth signals (IL4 IL13) provided by invading Th2 microenvironment....
Oncogenic KRAS (KRAS*) is a key tumor maintenance gene in pancreatic ductal adenocarcinoma (PDAC), motivating pharmacologic targeting of KRAS* and its effectors. Here, we explored mechanisms involving the microenvironment (TME) as potential basis for resistance to KRAS*. Using inducible Kras G12D;Trp53 -/- PDAC mouse model, gain-of-function screens epigenetic regulators identified HDAC5 top hit enabling independent growth. HDAC5-driven escaper tumors showed prominent neutrophil-to-macrophage...
Abstract Genetic inactivation of PTEN is common in prostate cancer and correlates with poorer prognosis. We previously identified CHD1 as an essential gene PTEN-deficient cells. Here, we sought definitive vivo genetic evidence for, mechanistic understanding of, the role cancer. In Pten Pten/Smad4 genetically engineered mouse models, prostate-specific deletion Chd1 resulted markedly delayed tumor progression prolonged survival. was associated profound microenvironment (TME) remodeling...
The ubiquitin-specific protease (USP) family is the largest group of cysteine proteases. Cancer genomic analysis identified frequent amplification USP21 (22%) in human pancreatic ductal adenocarcinoma (PDAC). overexpression correlates with PDAC progression, and enforced expression accelerates murine tumor growth drives PanIN to progression immortalized cells. Conversely, depletion impairs growth. Mechanistically, deubiquitinates stabilizes TCF/LEF transcription factor TCF7, which promotes...
Inactivation of adenomatous polyposis coli (APC) is common across many cancer types and serves as a critical initiating event in most sporadic colorectal cancers. APC deficiency activates WNT signaling, which remains an elusive target for therapy, prompting us to apply the synthetic essentiality framework identify druggable vulnerabilities APC-deficient Tryptophan 2,3-dioxygenase 2 (TDO2) was identified essential effector cancer. Mechanistically, results TCF4/β-catenin-mediated upregulation...
Abstract The tumor-derived factors involved in the expansion and accumulation of myeloid-derived suppressor cells (MDSCs) metastatic dissemination colorectal cancer (CRC) to liver has not been studied. Immunohistochemistry was used detect sphingosine-1-phosphate receptor 1 (S1PR1) signal transducer activator transcription-3 (STAT3) human tumors. IL-6 interferon-γ were detected by enzyme-linked immunosorbent assay (ELISA). Tumor growth, invasion, migration evaluated MTT, transwell, wound...
Abstract Germline telomere maintenance defects are associated with an increased incidence of inflammatory diseases in humans, yet whether and how dysfunction causes inflammation not known. Here, we show that drives pATM/c-ABL-mediated activation the YAP1 transcription factor, up-regulating major pro-inflammatory pro-IL-18. The colonic microbiome stimulates cytosolic receptors activating caspase-1 which cleaves pro-IL-18 into mature IL-18, leading to recruitment interferon (IFN)-γ-secreting T...
Macrophage polarization has a causal role in the pathogenesis and resolution of various clinical diseases. DNA-binding transcription factors (TFs) have been identified as essential during gene transcription. Better insight into TFs that regulate macrophage could provide novel therapeutic targets. IFN-γ (50 ng/mL) or IL4 (20 was utilized to stimulate bone marrow-derived macrophages from mice for 24 h M1- M2-polarized model construction, respectively. First, ATAC-seq (Assay Targeting...
ABSTRACT Background Intervertebral disc degeneration (IDD) is a major cause of cervical and lumbar diseases, significantly impacting patients' quality life. Mitochondria cell death have been implicated in IDD, but the key related genes remain unknown. Methods Differentially expressed (DEGs) between IDD control samples were identified using GSE70362. Mitochondria‐related (MRGs) programmed death‐related (PCDRGs) intersected with DEGs to find DE‐MRGs DE‐PCDRGs. Weighted gene co‐expression...
The dynamics of the spleen during tumor progression remains incompletely understood. In this study, we established a murine H22 orthotopic hepatoma model and dynamically detected alterations in percentages immunocytes spleen. We observed prominent myeloid-derived suppressor cell (MDSC) accumulation early response which persisted through all stages growth. addition, percentage regulatory T cells (Tregs) increased by week 2. Although CD3 + CD49b natural killer (NKT) day 3, that CD4 slightly 1,...
Activating mutations in KRAS (KRAS*) are present nearly all pancreatic ductal adenocarcinoma (PDAC) cases and critical for tumor maintenance. By using an inducible KRAS* PDAC mouse model, we identified a deubiquitinase USP21-driven resistance mechanism to anti-KRAS* therapy. USP21 promotes KRAS*-independent growth via its regulation of MARK3-induced macropinocytosis, which serves maintain intracellular amino acid levels anabolic growth. The USP21-mediated bypass, coupled with the frequent...
Purpose: In many diseases, an overabundance of macrophages contributes to adverse outcomes. While numerous studies have compared macrophage phenotype after mechanical stimulation or with varying local stiffness, it is unclear if and how themselves contribute forces in their microenvironment. Methods: Raw 264.7 murine were embedded a confining agarose gel, where they proliferated form spheroids over time. Gels synthesized at various concentrations tune the stiffness treated growth supplements...
Interleukin-34 (IL-34) is a recently discovered cytokine that promotes tissue macrophage maturation and differentiation. We previously found 1α,25-Dihydroxyvitamin D3 up-regulated IL-34 expression in SH-SY5Y neural cells. However, whether microRNA regulates not completely clear. By using on-line TargetScan MiRanda software, we there was only one conserved microRNA-31 (miR-31) binding site the 3' untranslated region (3'UTR) of mRNA. Intriguingly, qPCR demonstrated miR-31 levels were...
Lactate is a glycolysis end product, and its levels are markedly associated with disease severity, morbidity, mortality in sepsis. It modulates key functions of immune cells, including macrophages. In this investigation, transcriptomic analysis was performed using lactic acid, sodium lactate, hydrochloric acid-stimulated mouse bone marrow-derived macrophages (iBMDM), respectively, to identify lactate-associated signaling pathways. After 24 h stimulation, 896 differentially expressed genes...