A5052353752- Pregnancy and preeclampsia studies
- Ovarian function and disorders
- Cardiovascular Issues in Pregnancy
- Maternal and fetal healthcare
- Complement system in diseases
- Autophagy in Disease and Therapy
- Adenosine and Purinergic Signaling
- Assisted Reproductive Technology and Twin Pregnancy
- Ubiquitin and proteasome pathways
- Retinal Development and Disorders
- Folate and B Vitamins Research
- Sulfur-Based Synthesis Techniques
- Grief, Bereavement, and Mental Health
- Gestational Diabetes Research and Management
- Maternal and Perinatal Health Interventions
- Lipid metabolism and disorders
- Glaucoma and retinal disorders
- Synthesis and Catalytic Reactions
- Receptor Mechanisms and Signaling
- Hemoglobinopathies and Related Disorders
- Corneal surgery and disorders
- Asymmetric Hydrogenation and Catalysis
- Ovarian cancer diagnosis and treatment
- Peptidase Inhibition and Analysis
Johns Hopkins Medicine
2021-2023
Johns Hopkins University
2021-2023
Princeton University
2019-2020
The University of Queensland
2020
University of North Texas
2016
The ubiquitin-specific protease (USP) family is the largest group of cysteine proteases. Cancer genomic analysis identified frequent amplification USP21 (22%) in human pancreatic ductal adenocarcinoma (PDAC). overexpression correlates with PDAC progression, and enforced expression accelerates murine tumor growth drives PanIN to progression immortalized cells. Conversely, depletion impairs growth. Mechanistically, deubiquitinates stabilizes TCF/LEF transcription factor TCF7, which promotes...
Background Women with polycystic ovary syndrome (PCOS) have an increased risk of pregnancy-associated complications. However, data on peripartum cardiovascular complications remain limited. Hence, we investigated trends, outcomes, and predictors associated PCOS diagnosis during delivery hospitalizations in the United States. Methods Results We used from National Inpatient Sample (2002-2019). International Classification Diseases, Ninth Revision (ICD-9), or Tenth (ICD-10), codes were to...
Purpose: To measure quantitatively changes in lamina cribrosa (LC) cell and connective tissue structure human glaucoma eyes. Methods: We studied 27 19 age-matched non-glaucoma postmortem In 25 eyes, LC cross-sections were examined by confocal multiphoton microscopy to quantify structures identified anti-glial fibrillary acidic protein (GFAP), phalloidin-labeled F-actin, nuclear 4′,6-diamidino-2-phenylindole (DAPI), second harmonic generation imaging of beams. Additional light transmission...
Background: Women with polycystic ovary syndrome (PCOS) have increased risk of pregnancy-associated complications. However, there is scarcity data on the trends, outcomes, and predictors cardiovascular (CV) complications associated PCOS diagnosis during delivery hospitalizations in United States. Methods Results: We used from National Inpatient Sample. ICD-9 or ICD-10 codes were to identify diagnosis. A total 71,436,308 weighted US for deliveries identified 2002 2019. Of included...