A5022842565- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Cyclopropane Reaction Mechanisms
- Carbohydrate Chemistry and Synthesis
- Synthesis and Catalytic Reactions
- Chemical synthesis and alkaloids
- Click Chemistry and Applications
- Advanced Synthetic Organic Chemistry
- Chemical Reactions and Mechanisms
- Alkaloids: synthesis and pharmacology
- Organic Chemistry Cycloaddition Reactions
- Coordination Chemistry and Organometallics
- Synthesis and Biological Evaluation
- Fluorine in Organic Chemistry
- Chemical Synthesis and Reactions
- Chemical Reaction Mechanisms
- Synthesis and Reactivity of Heterocycles
- Glycosylation and Glycoproteins Research
- Asymmetric Hydrogenation and Catalysis
- Marine Sponges and Natural Products
- Synthesis and Characterization of Pyrroles
- Synthesis and Reactions of Organic Compounds
- Microbial Natural Products and Biosynthesis
- Oxidative Organic Chemistry Reactions
London School of Hygiene & Tropical Medicine
2024
Imperial College London
2018-2024
Peachtree Orthopaedic Clinic
2022
University of Michigan
2000-2019
Ann Arbor Center for Independent Living
1997-2008
Berry & Associates (United States)
2004-2008
University of California, Berkeley
2006
University of Notre Dame
1993
University of Wisconsin–Madison
1983
University of North Carolina at Chapel Hill
1980
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConfigurational stability of chiral, nonconjugated nitrogen-substituted organolithium compounds generated by tin-lithium exchange N-[(1-tri-n-butylstannyl)alkyl]imidazolidin-2-ones and -oxazolidin-2-onesWilliam H. Pearson, Aline C. Lindbeck, Jeff W. KampfCite this: J. Am. Chem. Soc. 1993, 115, 7, 2622–2636Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChelation-controlled facially selective cyclocondensation reactions of chiral alkoxy aldehydes: syntheses a mouse androgen and carbon-linked disaccharideSamuel J. Danishefsky, William H. Pearson, Daniel F. Harvey, Clarence Maring, James P. SpringerCite this: Am. Chem. Soc. 1985, 107, 5, 1256–1268Publication Date (Print):March 1, 1985Publication History Published online1 May 2002Published inissue 1 March...
Abstract The medical and scientific response to emerging established pathogens is often severely hampered by ignorance of the genetic determinants virulence, drug resistance clinical outcomes that could be used identify therapeutic targets forecast patient trajectories. Taking newly emergent multidrug-resistant bacteria Mycobacterium abscessus as an example, we show combining high-dimensional phenotyping with whole-genome sequencing in a phenogenomic analysis can rapidly reveal actionable...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereochemical studies on chiral, nonconjugated, nitrogen-substituted carbanions generated by tin-lithium exchangeWilliam H. Pearson and Aline C. LindbeckCite this: J. Am. Chem. Soc. 1991, 113, 22, 8546–8548Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/ja00022a065https://doi.org/10.1021/ja00022a065research-articleACS PublicationsRequest reuse...
The total synthesis of Kopsia lapidilecta alkaloid (+/-)-lapidilectine B is described. Notable elements this include the first natural products application Smalley azido-enolate cyclization to form 1,2-dihydro-3H-indol-3-one (indoxyl) core and installation pyrrolidine ring by a 2-azaallyllithium [3+2] cycloaddition with acetylene equivalent phenyl vinyl sulfide. Closure eight-membered perhydroazocine accomplished via intramolecular S(N)2 substitution mesylate. This constitutes member...
The intramolecular capture of benzocyclobutyl, benzocyclopentyl, and benzocyclohexyl carbocations 7 by azides produces spirocyclic aminodiazonium ions 8, which undergo 1,2-C-to-N rearrangement with loss dinitrogen to produce benzo-fused iminium resulting from either aryl (9) or alkyl (10) migration the electron-deficient nitrogen atom. Reduction affords regioisomeric 1-azabicyclo[m.n.0]alkanes, e.g., benzopyrrolizidines, benzoindolizidines, benzoquinolizidines,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntramolecular Schmidt reactions of azides with carbocations: synthesis bridged-bicyclic and fused-bicyclic tertiary aminesWilliam H. Pearson, Rajesh Walavalkar, Jeffrey M. Schkeryantz, Wen Kui Fang, James D. BlickensdorfCite this: J. Am. Chem. Soc. 1993, 115, 22, 10183–10194Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpiro asymmetric induction. 3. Synthesis of optically pure syn- or anti-.alpha.,.beta.-dihydroxy esters by the aldol condensation chiral glycolate enolatesWilliam H. Pearson and Minn Chang ChengCite this: J. Org. Chem. 1987, 52, 14, 3176–3178Publication Date (Print):July 1, 1987Publication History Published online1 May 2002Published inissue 1 July 1987https://pubs.acs.org/doi/10.1021/jo00390a044https://doi.org/10.1021/jo00390a044research-articleACS...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of (.+-.)-3-deoxy-D-manno-2-octulopyranosateSamuel J. Danishefsky, William H. Pearson, and Brigitte E. SegmullerCite this: Am. Chem. Soc. 1985, 107, 5, 1280–1285Publication Date (Print):March 1, 1985Publication History Published online1 May 2002Published inissue 1 March 1985https://pubs.acs.org/doi/10.1021/ja00291a030https://doi.org/10.1021/ja00291a030research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAzidomethyl phenyl sulfide. A synthon for NH2Barry M. Trost and William H. PearsonCite this: J. Am. Chem. Soc. 1981, 103, 9, 2483–2485Publication Date (Print):May 1, 1981Publication History Published online1 May 2002Published inissue 1 1981https://pubs.acs.org/doi/10.1021/ja00399a089https://doi.org/10.1021/ja00399a089research-articleACS PublicationsRequest reuse permissionsArticle Views1039Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views...
Overnutrition with dietary sugar can worsen infection outcomes in diverse organisms including insects and humans, through generally unknown mechanisms. In the present study, we show that adult Drosophila melanogaster fed high-sugar diets became more susceptible to by Gram-negative bacteria Providencia rettgeri Serratia marcescens . We found P S proliferate rapidly D a diet, resulting increased probability of host death. become hyperglycemic on find evidence extra carbon availability may...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGeneration of 2-azaallyl anions by the transmetalation N-(trialkylstannyl)methanimines. Pyrrolidine synthesis [3 + 2] cycloadditions with alkenesWilliam H. Pearson, Daniel P. Szura, and Michael J. PostichCite this: Am. Chem. Soc. 1992, 114, 4, 1329–1345Publication Date (Print):February 1, 1992Publication History Published online1 May 2002Published inissue 1 February...
[structure: see text] Nucleoside phosphoramidites bearing a fluorous dimethoxytrityl (FDMT) group were used to synthesize fluorous-tagged oligonucleotides, which subjected solid-phase extraction using pH-stable fluorinated adsorbent. On-column detritylation afforded the purified oligonucleotides. The affinity purification method offers one-pass loading without ammonia removal, high selectivity for removal of failure sequences, recoveries (typically 70-100%), and ability purify long...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe synthesis of pyrrolizidines and indolizidines by the intramolecular cycloaddition azides with electron-rich 1,3-dienes. A synthetic equivalent a nitrene-diene cycloadditionWilliam H. Pearson, Stephen C. Bergmeier, Samir Degan, Ko Chung Lin, Yam Foo Poon, Jeffrey M. Schkeryantz, John P. WilliamsCite this: J. Org. Chem. 1990, 55, 22, 5719–5738Publication Date (Print):October 1, 1990Publication History Published online1 May 2002Published inissue 1...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of .beta.-amino-.alpha.-hydroxy acids via aldol condensation a chiral glycolate enolate. A synthesis (-)-bestatinWilliam H. Pearson and Jennifer V. HinesCite this: J. Org. Chem. 1989, 54, 17, 4235–4237Publication Date (Print):August 1, 1989Publication History Published online1 May 2002Published inissue 1 August 1989https://pubs.acs.org/doi/10.1021/jo00278a050https://doi.org/10.1021/jo00278a050research-articleACS PublicationsRequest reuse...
The [3+2] cycloaddition of 2-azaallyl anions with alkenes represents an attractive strategy for the synthesis substituted pyrrolidines. Although cycloadditions stabilized by aryl and ester groups have been known more than three decades, only recently versions bearing simply hydrogen or alkyl discovered. These nonstabilized are generated low temperature transmetalation (2-azaallyl)stannanes alkyllithiums. resulting 2-azaallyllithiums undergo certain alkenes alkynes in both intra-...
The pyrrolizidine azasugars alexine (3) and australine (4) their stereoisomers are glycosidase inhibitors of potential therapeutic use. Since the inhibitory activity is profoundly effected by ring size modification, ring-expanded indolizidine analogs 7 (homoalexine), 8 (8-epihomoaustraline), 9 (homoaustraline), 10 (8-epihomoalexine) were prepared. l-Xylose was converted into diols 16, which transformed nine-membered lactones 18 Claisen rearrangment cyclic ketene acetal 17....
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTA Practical Synthesis of (−)-SwainsonineWilliam H. Pearson and Erik J. HembreView Author Information Department Chemistry, The University Michigan, Ann Arbor, Michigan 48109-1055 Cite this: Org. Chem. 1996, 61, 20, 7217–7221Publication Date (Web):October 4, 1996Publication History Received11 June 1996Published online4 October inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jo961101bhttps://doi.org/10.1021/jo961101bbrief-reportACS...