A5048548571- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Pancreatic function and diabetes
- Biochemical and Molecular Research
- Cancer Cells and Metastasis
- Genetic diversity and population structure
- Animal Behavior and Reproduction
- Colorectal Cancer Treatments and Studies
- Plant and animal studies
The University of Texas MD Anderson Cancer Center
2020
Rice University
2020
Abstract A hallmark of pancreatic ductal adenocarcinoma (PDAC) is an exuberant stroma comprised diverse cell types that enable or suppress tumor progression. Here, we explored the role oncogenic KRAS in protumorigenic signaling interactions between cancer cells and host cells. We show mutation (KRAS*) drives cell-autonomous expression type I cytokine receptor complexes (IL2rγ–IL4rα IL2rγ–IL13rα1) turn are capable receiving growth signals (IL4 IL13) provided by invading Th2 microenvironment....
Decision making is involved in many behaviors contributing to fitness, such as habitat choice, mate selection, and foraging. Because of this, high decision-making accuracy (i.e., selecting the option most beneficial for fitness) should be under strong selection. However, decision energetically costly, often involving substantial time energy survey environment obtain high-quality information. Thus, evolve, its benefits outweigh costs. Inconsistency net across environments hypothesized an...
<p>Supplementary Figures 1-6</p>
<div>Abstract<p>A hallmark of pancreatic ductal adenocarcinoma (PDAC) is an exuberant stroma comprised diverse cell types that enable or suppress tumor progression. Here, we explored the role oncogenic KRAS in protumorigenic signaling interactions between cancer cells and host cells. We show mutation (KRAS*) drives cell-autonomous expression type I cytokine receptor complexes (IL2rγ–IL4rα IL2rγ–IL13rα1) turn are capable receiving growth signals (IL4 IL13) provided by invading Th2...
<p>Supplementary Figures 1-6</p>
<div>Abstract<p>A hallmark of pancreatic ductal adenocarcinoma (PDAC) is an exuberant stroma comprised diverse cell types that enable or suppress tumor progression. Here, we explored the role oncogenic KRAS in protumorigenic signaling interactions between cancer cells and host cells. We show mutation (KRAS*) drives cell-autonomous expression type I cytokine receptor complexes (IL2rγ–IL4rα IL2rγ–IL13rα1) turn are capable receiving growth signals (IL4 IL13) provided by invading Th2...