A5071015712- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- Nanoplatforms for cancer theranostics
- Colorectal Cancer Treatments and Studies
- Inflammasome and immune disorders
- Metabolomics and Mass Spectrometry Studies
- Nanocluster Synthesis and Applications
- Sepsis Diagnosis and Treatment
- Immune cells in cancer
- Photodynamic Therapy Research Studies
- Advanced Nanomaterials in Catalysis
- Antimicrobial Peptides and Activities
- Circular RNAs in diseases
- Mycobacterium research and diagnosis
- Cancer, Lipids, and Metabolism
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
First Affiliated Hospital of Anhui Medical University
2022-2025
Anhui Medical University
2022-2025
Center for Excellence in Molecular Cell Science
2016-2019
Chinese Academy of Sciences
2019
University of Science and Technology of China
2017-2019
Abstract The inflammasome has an essential function in innate immune, responding to a wide variety of stimuli. Here we show that the lncRNA Neat1 promotes activation several inflammasomes. associates with NLRP3, NLRC4, and AIM2 inflammasomes mouse macrophages enhance their assembly subsequent pro-caspase-1 processing. also stabilizes mature caspase-1 promote interleukin-1β production pyroptosis. Upon stimulation inflammasome-activating signals, , which normally resides paraspeckles,...
Biofilm-associated infections (BAIs) have been considered a major threat to public health, which induce persistent and serious complications. The poor penetration of antibacterial agents in biofilm significantly limits the efficiency combating BAIs. Magnetic urchin-like core–shell nanospheres Fe3O4@Bi2S3 were developed for physically destructing inducing bacterial eradication via reactive oxygen species (ROS) generation innate immunity regulation. magnetic with sharp edges exhibited...
Cyclin D1 is a critical regulator of cell cycle progression and works at the G1 to S-phase transition. Here, we report isolation characterization novel c-Myc-regulated lncRNA LAST (LncRNA-Assisted Stabilization Transcripts), which acts as CCND1 mRNA stabilizer. Mechanistically, was shown cooperate with CNBP bind 5′UTR protect against possible nuclease targeting. In addition, data from RIP-seq RNA-seq showed that might not be only target CNBP; three additional mRNAs were post-transcriptional...
Lactate is a glycolysis end product, and its levels are markedly associated with disease severity, morbidity, mortality in sepsis. It modulates key functions of immune cells, including macrophages. In this investigation, transcriptomic analysis was performed using lactic acid, sodium lactate, hydrochloric acid-stimulated mouse bone marrow-derived macrophages (iBMDM), respectively, to identify lactate-associated signaling pathways. After 24 h stimulation, 896 differentially expressed genes...
Abstract Objective This study aimed to evaluate the correlation of circulating long noncoding RNAs (lncRNAs) expression with disease risk, severity, inflammatory cytokines levels and prognosis in patients sepsis. Methods Differential profiles lncRNA serum sepsis rats were screened by high-throughput transcriptome sequencing. Homologous lncRNAs upregulation group identified homology analysis humans. The differences these homologous 176 healthy controls (HCs) detected using reverse...