A5023056980- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Bone health and treatments
- Global Cancer Incidence and Screening
- Bone Metabolism and Diseases
- Veterinary Oncology Research
- Cancer Immunotherapy and Biomarkers
- Virus-based gene therapy research
- Colorectal Cancer Screening and Detection
- Economic and Financial Impacts of Cancer
- Cancer Genomics and Diagnostics
- Sulfur Compounds in Biology
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- Veterinary Equine Medical Research
- Diet and metabolism studies
- Infectious Diseases and Mycology
- Food composition and properties
- Ocular Surface and Contact Lens
- Bone Tumor Diagnosis and Treatments
- BRCA gene mutations in cancer
- Nanoparticles: synthesis and applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Adipokines, Inflammation, and Metabolic Diseases
The University of Texas MD Anderson Cancer Center
2019-2025
Russian Academy of Sciences
2023
The University of Texas Health Science Center at Houston
2020
Colorado Department of Public Health and Environment
2014-2017
Iowa State University
2010-2017
University of Florida
2016
University of Veterinary Medicine
2005-2015
South Coast College
2014
Calhoun Community College
2014
University of Colorado Denver
2006-2014
Immune checkpoint inhibitors (ICI) targeting CTLA4 or PD-1/PD-L1 have transformed cancer therapy but are associated with immune-related adverse events, including myocarditis. Here, we report a robust preclinical mouse model of ICI-associated myocarditis in which monoallelic loss Ctla4 the context complete genetic absence Pdcd1 leads to premature death approximately half mice. Premature results from myocardial infiltration by T cells and macrophages severe ECG abnormalities, closely...
Abstract Background: Barriers to timely resolution of abnormal cancer screening tests add health disparities among low-income, uninsured, and minority populations. We conducted a randomized trial evaluate the impact lay patient navigators on time completion follow-up testing patients with in medically underserved population. Methods: Denver Health, safety-net care system serving Denver, is one 10 performance sites participating Patient Navigation Research Program. Of 993 eligible subjects...
BACKGROUND Patient navigation may reduce cancer disparities associated with socioeconomic status (SES) and household factors. This study examined whether these factors were delays in diagnostic resolution among patients screening abnormalities patient ameliorated delays. METHODS analyzed data from 5 of 10 centers the National Cancer Institute's Navigation Research Program, which collected SES on employment, income, education, housing, marital status, composition. The primary outcome was time...
Patient Navigation is an intervention aimed at addressing cancer health disparities by eliminating barriers to diagnosis, treatment, and services. Three major patient navigation (PN) programs (The National Cancer Institute, The American Society &The Center for Medicare Medicaid Services) are underway address the needs of medically underserved patients. There has not been national training with a defined curriculum navigators (PNs). Curriculum PNs was created experts from three programs....
Abstract Background: There is limited high-quality evidence about the impact of patient navigation (PN) on outcomes for patients with diagnosed cancer. Methods: We pooled data from two sites national Patient Navigation Research Program. Patients (n = 438) newly breast 353) or colorectal cancer 85) were randomized to PN usual care. Trained lay navigators met help them assess treatment barriers and identify resources overcome barriers. used intent-to-treat analysis time completion primary...
Objectives. We evaluated whether a program to prevent coronary heart disease (CHD) with community health workers (CHWs) would improve CHD risk in public and care settings. Methods. The CHWs provided point-of-service screening, education, coordination residents 34 primarily rural Colorado counties. utilized motivational interviewing navigated those at for into medical lifestyle resources. A software application generated real-time 10-year Framingham Risk Score (FRS) guideline-based...
In 2014, Colorado began allowing sales of recreational marijuana. With no state models or national guidance to follow, public health officials are seeking lessons from medical marijuana prepare for implications more widely available legal
Nano-TiO2 is immunotoxic to fish and reduces the bactericidal function of neutrophils. Here, fathead minnows (Pimephales promelas) were exposed low high environmentally relevant concentration nano-TiO2 (2 ng g(-1) 10 μg body weight, respectively), challenged with common bacterial pathogens, Aeromonas hydrophila or Edwardsiella ictaluri. Pre-exposure significantly increased mortality during challenge. concentrated in kidney spleen. Phagocytosis assay demonstrated that has ability diminish...
Abstract Germline telomere maintenance defects are associated with an increased incidence of inflammatory diseases in humans, yet whether and how dysfunction causes inflammation not known. Here, we show that drives pATM/c-ABL-mediated activation the YAP1 transcription factor, up-regulating major pro-inflammatory pro-IL-18. The colonic microbiome stimulates cytosolic receptors activating caspase-1 which cleaves pro-IL-18 into mature IL-18, leading to recruitment interferon (IFN)-γ-secreting T...
Immune checkpoint blockade (ICB) has revolutionized cancer treatment, yet quality of life and continuation therapy can be constrained by immune-related adverse events (irAEs). Limited understanding irAE mechanisms hampers development approaches to mitigate their damage. To address this, we examined whether mice gained sensitivity anti-CTLA-4 (αCTLA-4)–mediated toxicity upon disruption gut homeostatic immunity. We found αCTLA-4 drove increased inflammation colonic tissue damage in with...
Objective— To document hepatozoonosis in dogs from Alabama and Georgia to report associated clinical signs, method of diagnosis, response treatment, course disease. Design— Retrospective case series. Animals— 22 which Hepatozoon canis was identified by microscopic examination skeletal muscle. Procedure— We reviewed medical records all with a definitive diagnosis that were referred the Auburn University Small Animal Clinic between 1989 1994. Results— Diagnoses confirmed identification H...
Community health workers (CHWs) are effective in improving access to care, promoting client knowledge and behavior change, contributing improved status of individuals. However, few outreach programs have evaluated the financial impact CHWs on care systems policies. A longitudinal repeated measures design was used assess return investment (ROI) by employed Denver Health Voices. Service utilization, charges reimbursements for 590 underserved men were analyzed 9 months before after interaction...
Abstract Spinal muscular atrophy (SMA) is caused by low levels of survival motor neuron (SMN), a multifunctional protein essential for higher eukaryotes. While SMN one the most scrutinized proteins associated with neurodegeneration, its gender-specific role in vertebrates remains unknown. We utilized mild SMA model (C/C model) to examine impact on growth and development mammalian sex organs. show impaired testis development, degenerated seminiferous tubules, reduced sperm count fertility C/C...
The diagnostic accuracy of contrast‐enhanced CT for detection cervical lymph node metastasis in dogs is unknown. purpose this retrospective, observational, study was to assess the efficacy mandibular and medial retropharyngeal dogs. Histopathology with cancer head, bilateral lymphadenectomy reviewed. A single radiologist measured nodes derive short axis width long‐short ratios. Two blinded radiologists separately assessed margins, attenuation contrast enhancement each provided a final...
On January 1, 2014, Colorado became the first state in nation to sell legal recreational marijuana for adult use. As a result, has had carefully examine potential population health and safety impacts as well role of public response legalization. We have discussed an emerging framework legalized marijuana. outlined this according core functions assessment, policy development, assurance. In addition, we challenges implementing that other states considering legalization may face.
In this study, fruit flies (Drosophila melanogaster) were exposed to an estimated daily human E171 consumption concentration for 20 generations. Exposure resulted in: a change in normal developmental and reproductive dynamics, reduced fecundity after repetitive breeding, increased genotoxicity, the appearance of aberrant phenotypes morphologic changes adult fat body. Marks adaptive evolution directional selection also exhibited. The larval stages at higher risk sustaining damage from as they...
Abstract The majority of TP53 missense mutations identified in cancer patients are the DNA-binding domain and characterized as either structural or contact mutations. These exhibit inhibitory effects on wild-type p53 activity. More importantly, these also demonstrate gain-of-function (GOF) activities by increased metastasis, poor prognosis, drug resistance. To better understand which mutations, Li–Fraumeni syndrome, contribute to tumorigenesis, we generated mice harboring a novel germline...
BACKGROUND Previous preclinical studies have demonstrated an altered gut microbiome after traumatic injury; however, the impact of sex on dysbiosis remains unknown. We hypothesized that “pathobiome” phenotype induced by multicompartmental injuries and chronic stress is host specific with unique signatures. METHODS Male proestrus female Sprague-Dawley rats (n = 8/group) aged 9 weeks to 11 were subjected either injury (PT) (lung contusion, hemorrhagic shock, cecectomy, bifemoral...
Lynch syndrome (LS), caused by inherited mutations in DNA mismatch repair genes including MSH2, carries a 60% lifetime risk of developing endometrial cancer (EC). Beyond hypermutability, mechanisms driving LS-associated EC remain unclear. We investigated MSH2 loss pathogenesis using mouse model (PR-Cre Msh2LoxP/LoxP, abbreviated Msh2KO), primary cell lines, human tissues, and cells with isogenic knockdown. By eight months, 58% Msh2KO mice developed atypical hyperplasia (AH), precancerous...
BACKGROUND Navigators can facilitate timely access to cancer services, but the authors' knowledge there are little data available regarding their economic impact. METHODS The authors conducted a cost‐consequence analysis of navigation versus usual care among 10,521 individuals with abnormal breast, cervical, colorectal, or prostate screening results who enrolled in Patient Navigation Research Program study from January 1, 2006 March 31, 2010. costs included diagnostic evaluation, patient and...