Christine B. Peterson
A5090179091- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Gut microbiota and health
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Antimicrobial Peptides and Activities
- Gene expression and cancer classification
- Radiomics and Machine Learning in Medical Imaging
- Chronic Lymphocytic Leukemia Research
- Tryptophan and brain disorders
- Bioinformatics and Genomic Networks
- Genetic Associations and Epidemiology
- Head and Neck Cancer Studies
- Metabolomics and Mass Spectrometry Studies
- Radiation Dose and Imaging
- Bayesian Methods and Mixture Models
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Lymphoma Diagnosis and Treatment
- Renal cell carcinoma treatment
- Neutropenia and Cancer Infections
- Lung Cancer Treatments and Mutations
The University of Texas MD Anderson Cancer Center
2016-2025
The University of Texas Health Science Center at Houston
2014-2024
Baylor College of Medicine
2022
Psyadon Pharmaceuticals (United States)
2011-2021
University of Missouri
2021
Cancer Research And Biostatistics
2019
Rice University
2012-2019
Oslo University Hospital
2019
University of Oslo
2019
Stanford University
2014-2018
Abstract Scalable, integrative methods to understand mechanisms that link genetic variants with phenotypes are needed. Here we derive a mathematical expression compute PrediXcan (a gene mapping approach) results using summary data (S-PrediXcan) and show its accuracy general robustness misspecified reference sets. We apply this framework 44 GTEx tissues 100+ from GWAS meta-analysis studies, creating growing public catalog of associations seeks capture the effects variation on human...
Gut bacteria modulate the response to immune checkpoint blockade (ICB) treatment in cancer, but effect of diet and supplements on this interaction is not well studied. We assessed fecal microbiota profiles, dietary habits, commercially available probiotic supplement use melanoma patients performed parallel preclinical studies. Higher fiber was associated with significantly improved progression-free survival 128 ICB, most pronounced benefit observed sufficient intake no use. Findings were...
Abstract A non-immunogenic tumor microenvironment (TME) is a significant barrier to immune checkpoint blockade (ICB) response. The impact of Polybromo-1 ( PBRM1 ) on TME and response ICB in renal cell carcinoma (RCC) remains be resolved. Here we show that / Pbrm1 deficiency reduces the binding brahma-related gene 1 (BRG1) IFNγ receptor 2 Ifngr2 promoter, decreasing STAT1 phosphorylation subsequent expression target genes. An analysis 3 independent patient cohorts murine pre-clinical models...
Abstract Gut-microbiota modulation shows promise in improving immune-checkpoint blockade (ICB) response; however, precision biomarker-driven, placebo-controlled trials are lacking. We performed a multicenter, randomized placebo-controlled, biomarker-stratified phase I trial patients with ICB-naïve metastatic melanoma using SER-401, an orally delivered Firmicutesenriched spore formulation. Fecal microbiota signatures were characterized at baseline; stratified by high versus low...
In this paper, we propose a Bayesian approach to inference on multiple Gaussian graphical models. Specifically, address the problem of inferring undirected networks in situations where some may be unrelated, while others share common features. We link estimation graph structures via Markov random field (MRF) prior which encourages edges. learn sample groups have shared structure by placing spike-and-slab parameters that measure network relatedness. This allows us information between groups,...
Abstract With the rise of both number and complexity traits interest, control false discovery rate (FDR) in genetic association studies has become an increasingly appealing accepted target for multiple comparison adjustment. While a robust FDR-controlling strategies exist, nature this error is intimately tied to precise way which discoveries are counted, performance procedures satisfactory only if there one-to-one correspondence between what scientists describe as unique rejected hypotheses....
Background Fecal microbiota transplantation (FMT) via colonoscopy or enema has become a commonly used treatment of recurrent C. difficile infection (CDI). Aims To compare the safety and preliminary efficacy orally administered lyophilized product compared with frozen by enema. Methods In single center, adults ≥ 3 episodes CDI were randomized to receive encapsulated fecal from 100–200 g donor feces (n = 31) FMT 100 34) Safety during three months post was primary study objective. Prevention...
To develop a head and neck normal structures autocontouring tool that could be used to automatically detect the errors in autocontours from clinically validated tool.An based on convolutional neural networks (CNN) was developed for 16 of tested identify contour multiatlas-based system (MACS). The computed tomography (CT) scans clinical contours 3495 patients were semiautomatically curated train validate CNN-based tool. final accuracy evaluated by calculating Sørensen-Dice similarity...
The majority of studies that provide insights into the influence microbiome on health hematologic malignancy patients have concentrated transplant setting. Here, we sought to assess predictive capacity gastrointestinal and its relationship infectious outcomes in with acute myeloid leukemia (AML).
Abstract Background Immune-checkpoint inhibitors (ICIs) changed the therapeutic landscape of patients with lung cancer. However, only a subset them derived clinical benefit and evidenced need to identify reliable predictive biomarkers. Liquid biopsy is non-invasive repeatable analysis biological material in body fluids promising tool for cancer biomarkers discovery. In particular, there growing evidence that extracellular vesicles (EVs) play an important role tumor progression tumor-immune...
Immune checkpoint blockade (ICB) has revolutionized cancer treatment, yet quality of life and continuation therapy can be constrained by immune-related adverse events (irAEs). Limited understanding irAE mechanisms hampers development approaches to mitigate their damage. To address this, we examined whether mice gained sensitivity anti-CTLA-4 (αCTLA-4)–mediated toxicity upon disruption gut homeostatic immunity. We found αCTLA-4 drove increased inflammation colonic tissue damage in with...
Requiring personalized genetic counseling may introduce barriers to cancer risk assessment, but it is unknown whether omitting could increase distress.
Purpose: This study aimed to use deep learning-based dose prediction assess head and neck (HN) plan quality identify suboptimal plans. Methods: A total of 245 VMAT HN plans were created using RapidPlan knowledge-based planning (KBP). subset 112 high-quality was selected under the supervision an radiation oncologist. We trained a 3D Dense Dilated U-Net architecture predict 3-dimensional distributions 3-fold cross-validation on 90 Model inputs included CT images, target prescriptions, contours...
Increasing evidence suggests that the gut microbiome may influence responses and toxicities associated with chimeric antigen receptor (CAR) therapy. We conducted whole-genome shotgun sequencing on stool samples (n=117) collected at various times from multiple myeloma patients (n=33) undergoing idecabtagene vicleucel (ide-cel) anti-B cell maturation CAR-T observed a significant decrease in bacterial diversity post-ide-cel infusion, along differences composition linked to therapy response...
Purpose To evaluate the uncertainty of radiomics features from contrast-enhanced breath-hold helical CT scans non-small cell lung cancer for both manual and semi-automatic segmentation due to intra-observer, inter-observer, inter-software reliability. Methods Three radiation oncologists manually delineated tumors twice 10 using two software tools (3D-Slicer MIM Maestro). Additionally, three observers without formal clinical training were instructed use tools, Lesion Sizing Toolkit (LSTK)...
The genetic basis of multiple phenotypes such as gene expression, metabolite levels, or imaging features is often investigated by testing a large collection hypotheses, probing the existence association between each traits and hundreds thousands genotyped variants. Appropriate multiplicity adjustment crucial to guarantee replicability findings, false discovery rate (FDR) frequently adopted measure global error. In interest interpretability, results are summarized so that reporting focuses on...
Abstract Plasma and tumor caveolin-1 (Cav-1) are linked with disease progression in prostate cancer. Here we report that metabolomic profiling of longitudinal plasmas from a prospective cohort 491 active surveillance (AS) participants indicates prominent elevations plasma sphingolipids AS progressors that, together Cav-1, yield prognostic signature for progression. Mechanistic studies the underlying supportive onco-metabolism reveal coordinated activities through which Cav-1 enables rewiring...
Abstract Expression quantitative trait locus (eQTL) mapping provides a powerful means to identify functional variants influencing gene expression and disease pathogenesis. We report the identification of cis-eQTLs from 7,051 post-mortem samples representing 44 tissues 449 individuals as part Genotype-Tissue (GTEx) project. find cis-eQTL for 88% all annotated protein-coding genes, with one-third having multiple independent effects. numerous tissue-specific cis-eQTLs, highlighting unique...
To evaluate the performance of an independent recalculation and compare it against current measurement-based patient specific intensity-modulated radiation therapy (IMRT) quality assurance (QA) in predicting unacceptable phantom results as measured by Imaging Radiation Oncology Core (IROC).When institutions irradiate IROC head neck IMRT phantom, they are also asked to submit their internal QA results. Separately from this, has previously created reference beam models on Mobius3D platform...