A5014526204- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
- Advanced MRI Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Head and Neck Cancer Studies
- Oral health in cancer treatment
- MRI in cancer diagnosis
- Radiation Detection and Scintillator Technologies
- Oral Health Pathology and Treatment
- Atomic and Subatomic Physics Research
- Nuclear Physics and Applications
- Electron Spin Resonance Studies
- Radiomics and Machine Learning in Medical Imaging
- Fault Detection and Control Systems
- Cancer Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Advanced Neuroimaging Techniques and Applications
- Cerebral Venous Sinus Thrombosis
- Glioma Diagnosis and Treatment
- Advanced X-ray and CT Imaging
The University of Texas MD Anderson Cancer Center
2016-2025
The University of Texas Health Science Center at Houston
2023-2024
University of Pittsburgh
2014-2018
Uptake of administered D-glucose (Glc) or 2-deoxy-D-glucose (2DG) has been indirectly mapped through the chemical exchange (CE) between glucose hydroxyl and water protons using CE-dependent saturation transfer (glucoCEST) magnetic resonance imaging (MRI). We propose an alternative technique-on-resonance CE-sensitive spin-lock (CESL) MRI-to enhance responses to changes. Phantom data simulations suggest higher sensitivity for this 'glucoCESL' technique (versus glucoCEST) in intermediate CE...
To evaluate the performance of an independent recalculation and compare it against current measurement-based patient specific intensity-modulated radiation therapy (IMRT) quality assurance (QA) in predicting unacceptable phantom results as measured by Imaging Radiation Oncology Core (IROC).When institutions irradiate IROC head neck IMRT phantom, they are also asked to submit their internal QA results. Separately from this, has previously created reference beam models on Mobius3D platform...
Abstract Purpose To quantify the impact of treatment planning system beam model parameters, based on actual spread in radiotherapy community data, clinical plans and determine which complexity metrics best describe modeling errors have dose accuracy. Methods Ten parameters for a Varian accelerator were modified RayStation to match data at 2.5, 25, 50, 75, 97.5 percentile levels. These modifications evaluated 25 patient cases, including prostate, non‐small cell lung, H&N, brain,...
Purpose Glucose uptake and metabolism can be measured by chemical exchange–sensitive spin‐lock (CESL) MRI with an administration of glucose or its analogs. This study investigates the sensitivity, spatiotemporal characteristics, signal source glucoCESL a 9L rat brain tumor model. Methods Dynamic CESL intravenous injection D‐glucose, 2‐deoxy‐D‐glucose (2DG), L‐glucose were compared gadolinium‐based dynamic contrast‐enhanced (DCE) MRI. Results The signals analogs have faster larger changes in...
Glucose transport is important for understanding brain glucose metabolism. We studied with a presumably non-toxic and non-metabolizable analog, 3-O-methyl-d-glucose, using chemical exchange-sensitive spin-lock MRI technique at 9.4 Tesla. 3-O-methyl-d-glucose showed comparable exchange properties d-glucose 2-deoxy-d-glucose in phantoms, higher lower sensitivity than Glc vivo experiments, respectively. The changes of the spin-lattice relaxation rate rotating frame (Δ R 1 ρ) normal rat peaked...
Abstract Purpose To create a snapshot of common practices for 3D‐CRT and intensity‐modulated radiation therapy (IMRT) QA through large‐scale survey compare to TG‐218 recommendations. Methods A IMRT was constructed at distributed by the IROC‐Houston center all institutions monitored IROC (n = 2,861). The first part asked about methods check dose delivery 3D‐CRT. bulk focused on QA, inquiring treatment modalities, standard tools used verify planned dose, how assessment agreement is calculated...
Osteoradionecrosis of the jaw (ORNJ) is a debilitating complication that affects up to 15% head and neck cancer patients who undergo radiotherapy. The ASCO/ISOO/MASCC-endorsed ClinRad severity classification system was recently proposed (and recommended in latest ASCO guidelines) incorporate radiographic findings for determining ORNJ based on vertical extent bone necrosis. However, variability imaging modalities specialty-specific knowledge may contribute disparities diagnosing classifying...
Stereotactic radiosurgery (SRS) is a common treatment for intracranial lesions. This work explores the state of SRS delivery to characterize current accuracy based on parameters.NCI clinical trials involving rely an end-to-end patient surrogate (credentialing phantom) from Imaging and Radiation Oncology Core (IROC) test their accuracy. The results 1072 phantom irradiations between 2012 2020 were retrospectively analyzed. Univariate analysis random forest models used associate irradiation...
To investigate the use of statistical process control (SPC) for quality assurance an integrated web-based autoplanning tool, Radiation Planning Assistant (RPA).Automatically generated plans were downloaded and imported into two treatment planning systems (TPSs), RayStation Eclipse, in which they recalculated using fixed monitor units. The then uploaded back to RPA, mean dose differences each contour between original RPA TPSs calculated. SPC was used characterize terms comparisons: TPS versus...
The purpose of this study is to evaluate the impact two methods reporting planned dose distributions on Gamma analysis pass rates for comparison with measured 2D film and simulated delivered 3D proton pencil beam scanning treatment Imaging Radiation Oncology Core (IROC) lung liver mobile phantoms.Four-dimensional (4D) computed-tomography (CT) image sets were acquired IROC phantoms, which include dosimetry inserts that contains targets, thermoluminescent dosimeters EBT2 films plan...
Purpose: To design a Head and Neck (H&N) anthropomorphic QA phantom that the Imaging Radiation Oncology Core Houston (IROC‐H) can use to verify quality of intensity modulated proton therapy (IMPT) H&N treatments for institutions participating in NCI clinical trials. Methods: The was created serve as remote auditing tool IROC‐H evaluate an institution's IMPT planning delivery abilities. based on composition, size, geometry generalized oropharyngeal tumor contains critical structures...
Purpose: To describe the results of IROC Houston's international and domestic end‐to‐end QA phantom irradiations. Methods: Houston has anthropomorphic lung, liver, head neck, prostate, SRS spine phantoms that are used for credentialing quality assurance purposes. The include structures closely mimic targets organs at risk made from tissue equivalent materials: high impact polystyrene, solid water, cork acrylic. Motion tables to breathing motion some lung liver phantoms. Dose is measured with...
Abstract Purpose To analyze trends in institutional performance and failure modes for the Imaging Radiation Oncology Core’s (IROC’s) proton liver phantom. Materials Methods Results of 66 phantom irradiations from 28 institutions between 2015 2020 were retrospectively analyzed. Univariate analysis random forest models used to associate irradiation conditions with results. Phantom results included pass/fail classification, average thermoluminescent dosimeter (TLD) ratio both targets,...