A5060697492- Melanoma and MAPK Pathways
- melanin and skin pigmentation
- Neurobiology and Insect Physiology Research
- Immune cells in cancer
- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Dermatology and Skin Diseases
- Computational Drug Discovery Methods
- Dietary Effects on Health
- Gut microbiota and health
- Immune Cell Function and Interaction
- Single-cell and spatial transcriptomics
The University of Texas MD Anderson Cancer Center
2021-2023
Gut bacteria modulate the response to immune checkpoint blockade (ICB) treatment in cancer, but effect of diet and supplements on this interaction is not well studied. We assessed fecal microbiota profiles, dietary habits, commercially available probiotic supplement use melanoma patients performed parallel preclinical studies. Higher fiber was associated with significantly improved progression-free survival 128 ICB, most pronounced benefit observed sufficient intake no use. Findings were...
Abstract Exercise changes the tumor microenvironment by remodeling blood vessels and increasing infiltration cytotoxic immune cells. The mechanisms driving these remain unclear. Herein, we demonstrate that exercise normalizes vasculature upregulates endothelial expression of VCAM1 in YUMMER 1.7 B16F10 murine models melanoma but differentially regulates growth, hypoxia, response. We found suppressed growth increased CD8+ T-cell not tumors. Single-cell RNA sequencing flow cytometry revealed...
<div>Abstract<p>Exercise changes the tumor microenvironment by remodeling blood vessels and increasing infiltration cytotoxic immune cells. The mechanisms driving these remain unclear. Herein, we demonstrate that exercise normalizes vasculature upregulates endothelial expression of VCAM1 in YUMMER 1.7 B16F10 murine models melanoma but differentially regulates growth, hypoxia, response. We found suppressed growth increased CD8+ T-cell not tumors. Single-cell RNA sequencing flow...
<p>Supplementary Figures S1-S8</p>
<p>Supplementary Figures S1-S8</p>
<div>Abstract<p>Exercise changes the tumor microenvironment by remodeling blood vessels and increasing infiltration cytotoxic immune cells. The mechanisms driving these remain unclear. Herein, we demonstrate that exercise normalizes vasculature upregulates endothelial expression of VCAM1 in YUMMER 1.7 B16F10 murine models melanoma but differentially regulates growth, hypoxia, response. We found suppressed growth increased CD8+ T-cell not tumors. Single-cell RNA sequencing flow...
<p>Supplementary Figures S1-S8</p>
<p>Supplementary Figures S1-S8</p>
<div>Abstract<p>Exercise changes the tumor microenvironment by remodeling blood vessels and increasing infiltration cytotoxic immune cells. The mechanisms driving these remain unclear. Herein, we demonstrate that exercise normalizes vasculature upregulates endothelial expression of VCAM1 in YUMMER 1.7 B16F10 murine models melanoma but differentially regulates growth, hypoxia, response. We found suppressed growth increased CD8<sup>+</sup> T-cell not tumors. Single-cell...
<p>Supplementary Figures S1-S8</p>
<div>Abstract<p>Exercise changes the tumor microenvironment by remodeling blood vessels and increasing infiltration cytotoxic immune cells. The mechanisms driving these remain unclear. Herein, we demonstrate that exercise normalizes vasculature upregulates endothelial expression of VCAM1 in YUMMER 1.7 B16F10 murine models melanoma but differentially regulates growth, hypoxia, response. We found suppressed growth increased CD8<sup>+</sup> T-cell not tumors. Single-cell...
<p>Supplementary Figures S1-S8</p>
<div>Abstract<p>Exercise changes the tumor microenvironment by remodeling blood vessels and increasing infiltration cytotoxic immune cells. The mechanisms driving these remain unclear. Herein, we demonstrate that exercise normalizes vasculature upregulates endothelial expression of VCAM1 in YUMMER 1.7 B16F10 murine models melanoma but differentially regulates growth, hypoxia, response. We found suppressed growth increased CD8<sup>+</sup> T-cell not tumors. Single-cell...
<p>Supplementary Figures S1-S8</p>
<p>Supplementary Figures S1-S8</p>