A5040904380- Primate Behavior and Ecology
- Animal Behavior and Reproduction
- Wildlife Ecology and Conservation
- Reproductive tract infections research
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Ion Transport and Channel Regulation
- Adipose Tissue and Metabolism
- Animal Vocal Communication and Behavior
- Evolution and Paleontology Studies
- Syphilis Diagnosis and Treatment
- Gut microbiota and health
- Morphological variations and asymmetry
- HIV/AIDS Research and Interventions
- Amphibian and Reptile Biology
- Livestock and Poultry Management
- Forensic Anthropology and Bioarchaeology Studies
- Chromosomal and Genetic Variations
- CRISPR and Genetic Engineering
- Nail Diseases and Treatments
- dental development and anomalies
- Culture, Economy, and Development Studies
- Virology and Viral Diseases
- Bat Biology and Ecology Studies
- Genomics and Phylogenetic Studies
Mammoth Biosciences (United States)
2025
Boston University
2015-2023
Bay State College
2019-2022
University of California, Berkeley
2015-2021
University of California, Los Angeles
2013-2018
Integra (United States)
2016
University of Southern California
1986-2014
New York University
2009-2014
Institute of Applied Economic Research
2012
Institute for Applied Economic Research
2012
Dispersal is a behavioral process that shuffles genes across the physical and social landscapes. Analysis of how genetic variation structured hierarchically among males versus females can provide insights into underlying dispersal processes, even when direct observations events are lacking, but application these techniques in primate studies has been limited. We investigated patterns two South American primates — woolly spider monkeys using combination multilocus genotype data from > 150...
The human gut microbiota interacts closely with diet and physiology. To better understand the mechanisms behind this relationship, microbiome research relies on complementing studies manipulations of animal models, including non-human primates. However, due to unique aspects physiology, it is likely that host-gut microbe interactions operate differently in humans Here, we show reacts a high-protein, high-fat Western than model primate, African green monkey, or vervet (Chlorocebus aethiops...
We describe a genome reference of the African green monkey or vervet (Chlorocebus aethiops). This member Old World (OWM) superfamily is uniquely valuable for genetic investigations simian immunodeficiency virus (SIV), which it most abundant natural host species, and wide range health-related phenotypes assessed in Caribbean vervets (C. a. sabaeus), whose numbers have expanded dramatically since Europeans introduced small their ancestors from West Africa during colonial era. use to...
Pathogenesis studies of SIV infection have not been performed to date in wild monkeys due difficulty collecting and storing samples on site the lack analytical reagents covering extensive diversity. We a large scale study molecular epidemiology natural history SIVagm 225 free-ranging AGMs from multiple locations South Africa. prevalence (established by sequencing pol, env, gag) varied dramatically between infant/juvenile (7%) adult animals (68%) (p<0.0001), females (78%) males (57%)....
Abstract CRISPR gene editing is a transformative technology for addressing genetic diseases, but delivery constraints have largely limited its therapeutic applications to liver-targeted and ex vivo therapies. Here, we present the discovery engineering of NanoCas, an ultracompact nuclease capable extending CRISPR’s reach in beyond liver targets. We experimentally screened 176 systems found metagenomic data applied protein approaches enhance efficiency NanoCas. The optimized NanoCas exhibits...
African green monkeys (AGMs) are naturally infected with simian immunodeficiency virus (SIV) at high prevalence levels and do not progress to AIDS. Sexual transmission is the main route in AGM, while mother-to-infant (MTIT) negligible. We investigated SIV wild AGMs assess whether or due differences mucosal permissivity (i.e., genetic bottleneck of viral reported humans macaques also observed wild). tested 121 sabaeus (Chlorocebus sabaeus) from Gambia found that 53 were (44%). By combining...
Significance Experimental research on mice has yielded tremendous biological insight. However, the ∼140 million y of evolution that separate from humans pose a hurdle to direct application this knowledge humans. We report here considerable progress for identifying genetically patterned skeletal phenotypes beyond mouse model is possible through transdisciplinary approaches include anatomical sciences. Indeed, anatomy and paleontology offer unique opportunities which develop test hypotheses...
Pathogen recognition receptors such as Toll-like (TLRs), which recognize pathogen-associated molecular patterns, lead to the activation of innate immunity. Genetic variations in these may an altered host immune response pathogens.We developed homogeneous fluorescence-based PCR assays well matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) genotyping detect TLR4 polymorphisms. These were compared with restriction fragment length polymorphism (RFLP)...
The proliferative responses of purified leukemic human B cells from nine cell chronic lymphocytic leukemias to recombinant interleukin 2 (IL-2), spontaneously, and after preactivation by Staphylococcus aureus Cowan I (SAC) or anti-mu antibodies were studied. Three patterns response observed: (a) no (three cases); (b) a moderate spontaneous enhanced (one case); (c) high and/or SAC (five cases). IL-2 could also trigger normal cells, spleen, SAC. These results provide evidence that is...
Synthesis of the sodium pump, Na+-K+-ATPase, is regulated by thyroid hormone in responsive tissues. The purpose this study was to determine if triiodothyronine (T3) regulates concentration mRNAs coding for two enzyme subunits, alpha and beta, time course response. A single dose T3 (250 micrograms/100 g body wt) administered hypothyroid rats that were killed at various times after injection. In kidney cortexes T3-injected animals, as well euthyroid rats, alpha- beta-mRNA concentrations...
In the brain there are two isozymes of Na+-K+-ATPase differing in their catalytic subunits: a, indistinguishable from kidney form and a+, found axolemma.The time course increase each a during development was described by quantitating abundance form, studied unpurified membranes resolved sodium dodecyl sulfate-polyacrylamide gel electrophoresis, with specific antibodies fluorescein 5'-isothiocyanate.Both a+ subunits, quantitated antibodies, increased 10fold 18 days gestation to 20 age,...
Abstract Objectives Direct comparative work in morphology and growth on widely dispersed wild primate taxa is rarely accomplished, yet critical to understanding ecogeographic variation, plastic local variation response human impacts, patterns of sexual dimorphism. We investigated population geographic variables (i.e., latitude, altitude), climatic temperature rainfall), impacts the vervet monkey ( Chlorocebus spp.). Methods trapped over 1,600 vervets from across Sub‐Saharan Africa Caribbean,...
Because so little is known about the pathogenesis of recurrent bacterial vaginosis (BV), a longitudinal microbiological study was conducted on 13 women with BV treated sequentially conventional metronidazole therapy. A rapid clinical response characterized by disappearance mal odor and an improvement in vaginal discharge occurred 92% 31 episodes BV, patients no longer satisfying composite criteria for diagnosis BV. However, prospective evaluation these asymptomatic revealed profound residual...
Abstract Vervet monkeys ( Chlorocebus aethiops ) exhibit bright blue scrotal skin which may function to mediate social interactions by acting as a socio‐sexual signal. Previous research on coloration among vervet was limited experimental work captive Ch. a. sabaeus , the least colorful subspecies, and two field studies of more pygerythrus . In study free‐ranging in South Africa ), West Caribbean we examined color variation across geographically distant subspecies. We provide an exploration...
Sexual traits vary tremendously in static allometry. This variation may be explained part by body size-related differences the strength of selection. We tested this hypothesis with two populations vervet monkeys, using estimates level condition dependence for different morphological as a proxy In support hypothesis, we found that steepness allometric slopes increased dependence. One trait particular interest, penis, had shallow and low levels dependence, agreement one most consistent...
In humans, the ontogeny of obesity throughout life course and genetics underlying it has been historically difficult to study. We compared, in a non-human primate model, lifelong growth trajectories obese non-obese adults assess heritability map potential genomic regions implicated obesity. A total 905 African green monkeys, or vervets (Chlorocebus aethiops sabaeus) (472 females, 433 males) from pedigreed captive colony. measured fasted body weight (BW), crown-to-rump length (CRL), body-mass...
The brain contains two molecular forms of Na,K-ATPase designated alpha found in non-neuronal cells and neuronal soma + axolemma. Previously we have shown that the abundance both (determined by immunoblots) as well activity increases 10-fold between 4 days before 20 after birth (Schmitt, C. A., McDonough, A. (1986) J. Biol. Chem. 261, 10439-10444). Hypothyroidism neonates blunts these increases. Neonatal, but not adult is thyroid hormone (triiodothyronine, T3) responsive. This study defines...
A growing focus of nonhuman primate conservation and management planning concerns factors affecting the dynamics parasite infection disease transmission. Here, we examine effects anthropogenic environmental components landscape on prevalence, richness, species diversity gastrointestinal parasites in wild-caught vervet monkeys (Chlorocebus aethiops) South Africa. Nematodes genus Trichuris family Strongylidae protists subclass Coccidia were present 55.13% sampled animals (n = 43)....
ABSTRACT Objective Vervet monkeys are common in most tree‐rich areas of South Africa, but their absence from grassland and semi‐desert the country suggest potentially restricted mosaic local population patterns that may have relevance to phenotype selection. A portion mitochondrial DNA control region was sequenced study genetic differentiation. Methods extracted, sequences were obtained 101 vervet at 15 localities, which represent both an extensive (widely across distribution range)...