A5027668355- Esophageal Cancer Research and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Estrogen and related hormone effects
- Eosinophilic Esophagitis
- Genetic factors in colorectal cancer
- Metastasis and carcinoma case studies
- Helicobacter pylori-related gastroenterology studies
- Breast Cancer Treatment Studies
- Pharmacogenetics and Drug Metabolism
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Sulfur Compounds in Biology
- HER2/EGFR in Cancer Research
- Drug Transport and Resistance Mechanisms
- Cancer Cells and Metastasis
- Glutathione Transferases and Polymorphisms
- Digestive system and related health
- Genomics, phytochemicals, and oxidative stress
- Gastrointestinal Tumor Research and Treatment
- Alcohol Consumption and Health Effects
- Esophageal and GI Pathology
- Microscopic Colitis
- Gastrointestinal disorders and treatments
George Washington University
2004-2025
George Washington University Hospital
2004-2024
Sinai Hospital
2023
King Abdulaziz University
2023
European Food Safety Authority
2022
The University of Texas Health Science Center at Houston
2012-2021
Texas Medical Center
2021
Memorial Hermann
2017-2021
University of Turin
2020
Tokyo Metropolitan Geriatric Hospital
2003-2018
Human fibroblasts in primary culture released reactive oxygen species upon stimulation with cytokines such as interleukin-1 alpha (IL-1) or tumour necrosis factor-alpha (TNF). The radical produced was O2.- determined by e.s.r. spin trapping and cytochrome c reduction. In contrast to the oxidative burst granulocytes monocytes, formation took place continuously for at least 4 h. Low-level chemiluminescence increased IL-1 TNF. Spectral characteristics tests azide led conclusion that...
Abstract Context.—During the last 50 years, incidence and mortality of gastric cancer has declined in many countries. This decline primarily included intestinal type (Lauren classification). However, there is an impression among pathologists that diffuse type, especially signet ring cell subtype, become more prevalent. Objectives.—Using data from Surveillance, Epidemiology, End Results (SEER) Program National Cancer Institute, we analyzed trends 2 primary types (intestinal diffuse)...
Increased expression of Glut1 and Glut3 has been reported in many human cancers, including nonsmall cell lung carcinoma (NSCLC). The aim this study was to determine the biologic significance overexpression Stage I NSCLC.Using immunohistochemistry polyclonal anti-Glut1 anti-Glut3 antibodies, authors immunostained sections formalin fixed, paraffin embedded tissues from 289 NSCLCs. Kaplan-Meier survival method, log rank test, Fisher's exact test were used for statistical analysis.Of cases, 49...
The clinicopathologic importance of a second estrogen receptor (ER), ER-beta, in breast cancers has been intensely studied; however, there is still no real consensus regarding the clinical utility an ER-beta assay, probably because lack standardized methodology, presence several isotypes (ER-beta1-5, and so on), and, more importantly, convincing data on whether status provides clinically useful information over what already provided by traditional ER-alpha/progesterone (PR) assay. A large...
The initial biopsy specimens from 50 patients with high-grade invasive transitional cell carcinoma of the urinary bladder were evaluated for depth invasion. Stages assigned according to following system: T1A, invasion connective tissue superficial level muscularis mucosae; T1B, T1C, through mucosae but propria; and B, into propria. Follow-up Yale Tumor Registry at a median time 4.6 years showed that tumors levels T1A T1B had 75% 5-year survival, apparently propria (level T1C) an 11% which...
Abstract BACKGROUND Estrogen receptors (ERs) are known to mediate important physiologic responses as well the growth of some tumors in response estradiol stimulation. In a previous study selective ER modulator raloxifene was shown induce apoptosis an ERβ‐positive bladder cancer cell line. However, expression ERβ human has not been thoroughly investigated. METHODS ERα and 224 tumor samples evaluated using tissue microarray immunohistochemistry. Levels protein mRNA were determined several...
Depletion of hepatic glutathione in phenobarbital-induced rats by phorone (diisopropylidene acetone) led to an enhancement spontaneous lipid peroxidation vitro. Addition exogenous glutathione, dithiocarb or one the flavonoids (+)-catechin, (-)-epicatechin, 3-O-methylcatechin, quercetin, taxifolin, rutin, naringin naringenin every case a dose-dependent inhibition this peroxidative activity. The concentration values yielding 50% (I50) varied from 1.0 × 10-6 M for 1.9 10-5 naringenin. Naringin...
Summary Tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL/Apo2L) is a death protein that preferentially kills tumour cells while sparing normal cells. TRAIL has four exclusive receptors, two of which (TRAIL‐R1, TRAIL‐R2) are receptors. Both TRAIL/Apo2L and agonistic antibodies to the receptors currently being explored for cancer therapy. Although activity in variety haematological malignancies been examined, anti‐TRAIL receptor primary cultured lymphoma not. Using fully human...