A5100718181- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Genomics and Chromatin Dynamics
- Immune Cell Function and Interaction
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Tannin, Tannase and Anticancer Activities
- Pancreatic and Hepatic Oncology Research
- Microbial Metabolism and Applications
- Viral-associated cancers and disorders
- Monoclonal and Polyclonal Antibodies Research
- Genomics and Phylogenetic Studies
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Complement system in diseases
- Lung Cancer Treatments and Mutations
- Hippo pathway signaling and YAP/TAZ
- Hepatitis Viruses Studies and Epidemiology
- Ferroptosis and cancer prognosis
- Lymphoma Diagnosis and Treatment
- Immune cells in cancer
- Radiomics and Machine Learning in Medical Imaging
- interferon and immune responses
Immunitas Therapeutics (United States)
2023-2024
National Center for Nanoscience and Technology
2023-2024
Dana-Farber Cancer Institute
2020-2024
Guizhou Normal University
2024
First People's Hospital of Yunnan Province
2023-2024
Kunming University of Science and Technology
2023-2024
Sun Yat-sen University
2023-2024
Sun Yat-sen University Cancer Center
2023-2024
Dalian Medical University
2020-2024
Chongqing Medical University
2020-2024
Gene fusion represents a class of molecular aberrations in cancer and has been exploited for therapeutic purposes. In this paper we describe TumorFusions, data portal that catalogues 20 731 gene fusions detected 9966 well characterized samples 648 normal specimens from The Cancer Genome Atlas (TCGA). spans 33 types TCGA. Fusion transcripts were identified via uniform pipeline, including filtering against list 3838 transcript panel non-neoplastic samples. Fusions mapped to somatic DNA...
Abstract Immune checkpoint therapies exhibit impressive efficacy in some patients with melanoma or lung cancer, but the lack of response most cases presses question how general can be improved. In addressing this question, we generated a preclinical tumor model to study anti-PD-1 resistance by vivo passaging Kras-mutated, p53-deficient murine cancer cells (p53R172HΔg/+K-rasLA1/+) syngeneic host exposed repetitive dosing anti-mouse PD-1 antibodies. PD-L1 (CD274) expression did not differ...
Abstract We present Model-based AnalysEs of Transcriptome and RegulOme (MAESTRO), a comprehensive open-source computational workflow ( http://github.com/liulab-dfci/MAESTRO ) for the integrative analyses single-cell RNA-seq (scRNA-seq) ATAC-seq (scATAC-seq) data from multiple platforms. MAESTRO provides functions pre-processing, alignment, quality control, expression chromatin accessibility quantification, clustering, differential analysis, annotation. By modeling gene regulatory potential...
Oncogenic KRAS (KRAS*) is a key tumor maintenance gene in pancreatic ductal adenocarcinoma (PDAC), motivating pharmacologic targeting of KRAS* and its effectors. Here, we explored mechanisms involving the microenvironment (TME) as potential basis for resistance to KRAS*. Using inducible Kras G12D;Trp53 -/- PDAC mouse model, gain-of-function screens epigenetic regulators identified HDAC5 top hit enabling independent growth. HDAC5-driven escaper tumors showed prominent neutrophil-to-macrophage...
Abstract As sequencing depth of chromatin studies continually grows deeper for sensitive profiling regulatory elements or spatial structures, aligning and preprocessing these data have become the bottleneck analysis. Here we present Chromap, an ultrafast method high throughput profiles. Chromap is comparable to BWA-MEM Bowtie2 in alignment accuracy over 10 times faster than traditional workflows on bulk ChIP-seq/Hi-C profiles 10x Genomics’ CellRanger v2.0.0 pipeline single-cell ATAC-seq
Carcinoma cells can acquire increased motility and invasiveness through epithelial-to-mesenchymal transition (EMT). However, the significance of EMT in cancer metastasis has been controversial, exact fates functions vivo remain inadequately understood. Here, we tracked epithelial that underwent inducible or spontaneous various tumor transplantation models. Unlike cells, majority were specifically located perivascular space closely associated with blood vessels. markedly activated multiple...
Abstract Renal fibrosis is the final manifestation of various chronic kidney diseases, and no effective therapy available to prevent or reverse it. Celastrol, a triterpene that derived from traditional Chinese medicine, known potent anti-fibrotic agent. However, underlying mechanisms action celastrol on renal remain unknown. In this study, we found treatment remarkably attenuated unilateral ureteral obstruction (UUO)-induced mouse fibrosis. This was evidenced by significant reduction in...
Abstract Background Although native to North America, the invasion of aphid-like grape phylloxera Daktulosphaira vitifoliae across globe altered course cultivation. For past 150 years, viticulture relied on grafting-resistant American Vitis species as rootstocks, thereby limiting genetic stocks tolerant other stressors such pathogens and climate change. Limited understanding insect genetics resulted in successive outbreaks when rootstocks failed. Here we report 294-Mb genome D. a basic tool...
Enhancer aberrations are beginning to emerge as a key epigenetic feature of colorectal cancers (CRC), however, comprehensive knowledge chromatin state patterns in tumour progression, heterogeneity these and imparted therapeutic opportunities remain poorly described.We performed epigenomic characterisation by mapping 222 profiles from 69 samples (33 adenocarcinomas, 4 adenomas, 21 matched normal tissues 11 colon cancer cell lines) for six histone modification marks: H3K4me3 Pol II-bound...
Background Population growth, aging, and major alterations in epidemiologic trends inadvertently modulate the status of rheumatic heart disease (RHD) epidemiology. This investigation predicted RHD burden pattern temporal to provide evidence. Methods Results Prevalence, mortality, disability-adjusted life-years data for were obtained from GBD (Global Burden Disease) study. We performed decomposition analysis frontier assess variations 1990 2019. In 2019, there >40.50 million cases worldwide,...
Predictive biomarkers of immune checkpoint inhibitor (ICI) efficacy are currently lacking for non-small cell lung cancer (NSCLC). Here, we describe the results from Anti-PD-1 Response Prediction DREAM Challenge, a crowdsourced initiative that enabled assessment predictive models by using data two randomized controlled clinical trials (RCTs) ICIs in first-line metastatic NSCLC.
A truncated structural protein of hepatitis E virus (HEV), p239, occurs as 23 nm particles consisting partial homodimers. As the latter resemble HEV capsomere structurally and antigenically, it was postulated that recombinant may serve a probe for receptor. This hypothesis supported by findings purified p239 bound penetrated different cell lines are susceptible to HEV, inhibited infection these cells. The binding blocked four six monoclonal antibodies (mAbs) reactive against dimeric domain...
Although human ZMYND8 has been implicated as a transcriptional co-repressor of multiple targets, global association with active genes and enhancer regions predicts otherwise. Here, we report an additional function in activation through its the P-TEFb complex. Biochemical reconstitution analyses show that ZMYND8, direct CylcinT1, forms minimal ZMYND8-P-TEFb The importance target gene activation, complex recruitment, is demonstrated on chromosomally integrated reporter well native vivo....