A5101873840- Peptidase Inhibition and Analysis
- Drug Transport and Resistance Mechanisms
- Cancer Cells and Metastasis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lysosomal Storage Disorders Research
- Cardiac Fibrosis and Remodeling
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Immunotherapy and Biomarkers
- Pharmacogenetics and Drug Metabolism
- Liver physiology and pathology
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Esophageal Cancer Research and Treatment
- Analytical Methods in Pharmaceuticals
- Cell Adhesion Molecules Research
- Studies on Chitinases and Chitosanases
- Glioma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Pancreatic and Hepatic Oncology Research
- Neonatal Health and Biochemistry
- GDF15 and Related Biomarkers
- Pharmacological Effects and Assays
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
Shanghai Jiao Tong University
2017-2025
Shanghai Cancer Institute
2022-2025
Renji Hospital
2022-2025
Yancheng Institute of Technology
2025
China Pharmaceutical University
2014-2024
Second Affiliated Hospital of Zhejiang University
2015-2024
National Medical Products Administration
2023
State Key Laboratory of Oncogene and Related Genes
2020-2023
XinHua Hospital
2021-2023
Illinois Department of Public Health
2016-2021
•Epithelial subtype 1, 2 and 3 were mainly found in the adenocarcinoma 4 was present adenosquamous carcinoma.•Tumors with ErbB pathway mutations harbored a larger population of 1 epithelial cells, Tregs, M2 macrophages.•Increased MDK these tumors interacted its receptor LRP1 to promote immunosuppressive macrophage differentiation.•Crosstalk between macrophage-secreted CXCL10 CXCR3 on Tregs induced GBC mutations. Background & AimsOur previous genomic whole-exome sequencing (WES) data...
The late stages of human breast cancer development are poorly understood complex processes associated with the expression genes by cancers that promote specific tumorigenic activities, such as angiogenesis. Here, we describe identification periostin a mesenchyme-specific gene whose acquired leads to significant enhancement in tumor progression and Undetectable normal tissues, was found be overexpressed vast majority primary examined. Tumor cell lines engineered overexpress showed phenotype...
GATA3, a transcription factor that regulates T lymphocyte differentiation and maturation, is exclusively expressed in early stage well differentiated breast cancers but not advanced invasive cancers. However, little understood regarding its activity the mechanisms underlying this differential expression Here, we employed GATA3-positive, non-invasive (MCF-7) GATA3-negative, (MDA-MB-231) cancer cells to define role transformation between these two distinct phenotypes. Ectopic of GATA3...
Tumor metastasis is a multistep pathological process involved in the final phase of tumor development. During this process, epithelium-derived cells undergo fibroblast-like transformation, referred to as epithelial-mesenchymal transition (EMT), which contributes aggressive behavior tumors. We identify periostin, mesenchyme-specific gene product, contributor EMT and metastatic potential. Stable expression periostin transgene tumorigenic but non-metastatic 293T caused transformation...
Recent evidence has shown that glioblastoma stem-like cells (GSCs) can transdifferentiate into endothelial and vascular-like tumor cells. The latter pattern of vascularization indicates an alternative microvascular circulation known as vasculogenic mimicry (VM). However, it remains to be clarified how the GSC-driven VM makes a significant contribution vasculature. Here, we investigated 11 cases glioblastomas found most them consisted blood-perfused vascular channels coexpress mural cell...
Reduced production of nitric oxide (NO) in the cirrhotic liver results from a defect hepatic endothelial cell synthase (ecNOS) and appears to contribute high intrahepatic resistance portal hypertension typical cirrhosis. Therefore, we postulated that targeting heterologous NOS isoform sinusoidal cells or other perisinusoidal cells, such as stellate would counter NO reduce blood flow. Recombinant adenovirus (Ad) carrying neuronal gene (nNOS) targeted hepatocytes more efficiently than...
Carcinoma cells can acquire increased motility and invasiveness through epithelial-to-mesenchymal transition (EMT). However, the significance of EMT in cancer metastasis has been controversial, exact fates functions vivo remain inadequately understood. Here, we tracked epithelial that underwent inducible or spontaneous various tumor transplantation models. Unlike cells, majority were specifically located perivascular space closely associated with blood vessels. markedly activated multiple...
Angiogenesis plays an important role in tumor development and metastasis, many cancer cells upregulate VEGF expression to promote angiogenesis. Silencing by RNA interference is expected be a promising strategy suppress the growth. However, low transfection efficiency instability are main barriers for small interfering (siRNA) delivery. In this study, we developed polycation liposome-encapsulated calcium phosphate nanoparticles (PLCP) siRNA delivery vivo. silencing effect MCF-7 was...
Abstract Background: Gallbladder cancer (GBC) is the most common malignant tumor of biliary tract. Isoliquiritigenin (ISL) a natural compound with chalcone structure extracted from roots licorice and other plants. Relevant studies have shown that ISL has strong anti-tumor ability in various types tumors. However, research against GBC not been reported, which needs to be further investigated. Methods: The effects cells vitro vivo were characterized by cytotoxicity test, RNA-sequencing,...
Soy isoflavones are natural tyrosine kinase inhibitors closely associated with decreased morbidity and mortality of various tumors. The activation kinases such as ERBB2 is the mechanism by which cholecystitis transforms into gallbladder cancer (GBC), therefore, it important to investigate relationship between long-term exposure soy occurrence progression GBC. This case-control study (n = 85 pairs) found that high level plasma isoflavone-genistein (GEN) was a lower risk (≥326.00 ng/mL...
Abstract Aberrant RNA alternative splicing in cancer generates varied novel isoforms and protein variants that facilitate progression. Here, we employed the advanced long-read full-length transcriptome sequencing on gallbladder normal tissues, tumors, cell lines to establish a comprehensive transcriptomic atlas. It is of note receptor tyrosine kinases were one most dynamic components with highly variable transcript, Erb-B2 kinase 2 (ERBB2) as prime representative. A designated ERBB2 i14e,...
Endothelin-1 (ET-1) is involved in the pathogenesis of a number diseases, including wound healing. In cirrhosis, wounding response liver, circulating ET-1 levels are elevated; moreover, has potent effects on hepatic stellate cells, key effectors cirrhosis. this study, we have examined regulatory role ECE-1, critical enzyme synthesis, two major cellular sources ET-1. release from normal endothelial cells was 25-fold higher than that cells. However, after liver injury, increased but markedly...
Deep functional changes occurring within the endometrium during implantation are orchestrated by embryonic and maternal signals. Human chorionic gonadotropin (hCG), a major signal, plays critical role in initiation maintenance of pregnancy. Interleukin (IL) 1, one earliest signals, appears to exert direct impact on receptive induce molecular that essential for embryo implantation. Herein we investigate whether hCG can modulate endometrial stromal cell (ESC) receptivity IL1 window assess...
Cholangiocarcinoma (CCA) is a rare malignancy of the biliary tract with extremely poor clinical outcomes due to lack effective therapies improve disease management. The emerging green synthesis gold nanoparticles (AuNPs) has extensively provided their use in biomedical applications. In this study, we developed AuNPs via reducing salts apigenin (4',5,7-trihydroxyflavone). synthesized apigenin-conjugated (api-AuNPs) were physicochemically characterized by various techniques before evaluation...
Statewide newborn screening for Pompe disease began in Illinois 2015. As of 30 September 2019, a total 684,290 infants had been screened and 395 (0.06%) were screen positive. A 29 cases identified (3 infantile, 26 late-onset). While many the remainder found to have normal alpha-glucosidase activity on follow-up testing (234 395), other findings included 62 carriers, 39 with pseudodeficiency, eight who could not be given definitive diagnosis due inconclusive testing.
We aimed to provide insight into differences in drug review decisions made by the US Food and Drug Administration's (FDA) accelerated approval (AA) pathway European Medicines Agency's (EMA) conditional marketing authorisation (CMA) pathway, add current knowledge base of processes.This cross-sectional study thoroughly examines novel oncology drugs with dual through FDA AA EMA CMA between 2006 2021. Statistical analysis was performed from June July 2022.The examined regulatory regions for...
Signaling pathways engaged by angiogenic factors bFGF and VEGF in tumor angiogenesis are not fully understood. The current study identifies cytoplasmic tyrosine kinase c-Abl as a key factor differentially mediating bFGF- VEGF-induced microvascular endothelial cells. STI571, inhibitor, only inhibited but angiogenesis. induced membrane receptor cooperation between integrin beta(3) FGF receptor, triggered downstream cascade including FAK, c-Abl, MAPK. This signaling pathway is different from...
Objective: The study aimed to assess the cost-effectiveness of sintilimab combined with cisplatin plus paclitaxel versus chemotherapy alone as first-line treatment in patients advanced or metastatic esophageal squamous cell carcinoma from Chinese healthcare system. Materials and methods: A partitioned survival model was developed based on ORIENT-15 clinical trial. Drug costs health state utility were obtained literature. Outcomes included outcomes life-years, quality-adjusted life-years...
Understanding their Mechanism of ActionAlzheimer's disease (AD) is a progressive neurodegenerative disorder associated with memory impairment and cognitive deficit, which characterized low levels acetylcholine, neurotransmitter, in the brain patients.Histopathological hallmarks AD include deposition -amyloid (A ) plaques formation neurofibrillary tangles.According to cholinergic hypothesis, acetylcholinesterase (AChE) catalyzes hydrolysis acetylcholine inhibition AChE improves brain,...
During hepatic wound healing, activation of key effectors the wounding response known as stellate cells leads to a multitude pathological processes, including increased production endothelin-1 (ET-1). This latter process has been linked enhanced expression endothelin-converting enzyme-1 (ECE-1, enzyme that converts precursor ET-1 mature peptide) in activated cells. Herein, we demonstrate up-regulation 56- and 62-kDa ECE-1 3′-untranslated region (UTR) mRNA binding proteins after liver injury...