A5083310919- Wheat and Barley Genetics and Pathology
- European history and politics
- Rice Cultivation and Yield Improvement
- Crop Yield and Soil Fertility
- Genetic Mapping and Diversity in Plants and Animals
- Plant nutrient uptake and metabolism
- Legume Nitrogen Fixing Symbiosis
- Genetic and Kidney Cyst Diseases
- German Social Sciences and History
- Plant-Microbe Interactions and Immunity
- Renal and related cancers
- Genetic and Environmental Crop Studies
- Genomics and Chromatin Dynamics
- Plant Molecular Biology Research
- Photosynthetic Processes and Mechanisms
- Genetics and Neurodevelopmental Disorders
- Genetics and Plant Breeding
- Historical Studies and Socio-cultural Analysis
- Lymphoma Diagnosis and Treatment
- Chromosomal and Genetic Variations
- Psychometric Methodologies and Testing
- Systemic Lupus Erythematosus Research
- Plant responses to elevated CO2
- Health and Medical Studies
- Lysosomal Storage Disorders Research
Heinrich Heine University Düsseldorf
2005-2025
Research Institute of Organic Agriculture
2025
Hochschule Düsseldorf University of Applied Sciences
2019-2025
University of Bonn
2019-2024
Forschungsinstitut für Biologischen Landbau
2024
University of Pennsylvania
2024
Cluster of Excellence on Plant Sciences
2023
Comprehensive Cancer Center Erlangen
2023
Friedrich-Alexander-Universität Erlangen-Nürnberg
2014-2023
Universitätsklinikum Erlangen
2023
Abstract Renal agenesis is a devastating birth defect, and although genes encoding retinoic acid signaling components have been shown to be important for renal... (RA) one of the more extreme examples congenital anomalies kidney urinary tract (CAKUT). Bilateral renal almost invariably fatal at birth, unilateral can lead future health issues including end-stage disease. Genetic investigations identified several gene variants that cause RA, EYA1, LHX1, WT1. However, whereas compound null...
Plants are constantly challenged by pathogens, which can cause substantial yield losses. The aggressiveness of and damage pathogens depends on the host-associated microbiome, might be shaped plant genetics to improve resistance. How different crop genotypes modulate their microbiota when a complex is largely unknown. Here, we investigate if how pea ( Pisum sativum L.) shape root upon challenge soil-borne this relates genotype's Building phenotyping efforts 252 grown in naturally infested...
Abstract The Hessian metallurgical company Isabellenhütte Gmbh in Dillenburg was a science-based that applied for and granted number of patents from the late 19th century onwards. Among these patent «iron-containing manganese copper alloys» issued 1917. article examines strategies used to observe challenge competing other companies, such as Metallgesellschaft AG, Frankfurt a.M. As small, family-run company, most likely be successful its efforts bring down if, on one hand, there factual basis...
More than 30% of adrenal pheochromocytomas are hereditary. These neuroendocrine tumors major components three inherited cancer syndromes: multiple endocrine neoplasia type 2, von Hippel-Lindau disease (VHL), and pheochromocytoma/paraganglioma syndrome (PC/PGL). Germline mutations in RET; VHL; SDHB, SDHC, SDHD associated with VHL, PC/PGL, respectively. The majority (>70%) hereditary extraadrenal PCs [catecholamine-secreting paragangliomas (PGL)] accounted for by germline intragenic or SDHD....
Understanding the genetic and molecular function of nitrate sensing acquisition across crop species will accelerate breeding cultivars with improved nitrogen use efficiency (NUE). Here, we performed a genome-wide scan using wheat barley accessions characterized under low high N inputs that uncovered NPF2.12 gene, encoding homolog Arabidopsis transceptor NRT1.6 other low-affinity transporters belong to MAJOR FACILITATOR SUPERFAMILY. Next, it is shown variations in promoter correlated altered...
A new human gene has been identified on chromosome 16 in the interval containing locus for polycystic kidney disease (PKD1) by analysis of a genomic cosmid clone and cDNAs. The contains at least one intron is actively transcribed tissues from brain. putative product predicted to be homologous yeast scERV1 protein virtue high degree identity (42%) over entire length polypeptides. In former studies yeastscERV1gene was found essential oxidative phosphorylation, maintenance mitochondrial...
Abstract Background Bread wheat is one of the most important crops for human diet, but increasing soil salinization causing yield reductions worldwide. Improving salt stress tolerance in requires elucidation mechanistic basis plant response to this abiotic factor. Although several studies have been performed analyze adaptation stress, there are still some gaps fully understand molecular mechanisms from initial signal perception onset responsive pathways. The main objective study exploit...
In addition to heterogeneity and artificial selection, natural selection is one of the forces used combat climate change improve agrobiodiversity in evolutionary plant breeding. Accurate identification specific genomic effects will likely accelerate transfer between populations. Thus, insights into changes allele frequency, adequate population size, gene flow drift are essential. However, observing such often involves a trade-off costs resolution when large sample genotypes for many loci...
The manifestation and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections show a clear correlation to the age patient. younger person, less likely infection results in significant illness. To explore immunological characteristics behind this phenomenon, we studied course SARS-CoV-2 11 households, including 8 children 6 infants/neonates women who got infected with during pregnancy.We investigated immune responses peripheral blood mononuclear cells (PBMCs),...
Abstract Comprehensive maps of functional variation at transcription factor (TF) binding sites ( cis -elements) are crucial for elucidating how genotype shapes phenotype. Here we report the construction a pan-cistrome maize leaf under well-watered and drought conditions. We quantified haplotype-specific TF footprints across pan-genome 25 hybrids mapped over two-hundred thousand genetic variants (termed binding-QTL) linked to -element occupancy. Three lines evidence support significance...
Abstract A primary goal of standards-based statewide achievement tests is to classify students into levels that enable valid inferences about student content area knowledge and skill. Explicating how skills are expected differ in complexity level descriptors, related empirical item difficulty—at the beginning assessment design, rather than at end—is critical those inferences. The purpose this study investigate whether sources skill descriptions commonly found achievement-level descriptors...
Water deficit is one of the major limitations to food production worldwide and most climate change scenarios predict an aggravation situation. To face expected increase in drought stress coming years, breeders are working elucidate genetic control barley growth productivity traits under water deficit. Barley known as a relatively tolerant crop variability was observed for tolerance traits. The objectives present study were quantification morphological physiological responses collection 209...
Abstract Sustainable food production for a growing world population will pose central challenge in the coming decades. Organic farming is among feasible approaches to achieving this goal if yield gap conventional can be decreased. However, uncertainties exist which extend—and phenotypes particular—organic and agro-ecosystems require differentiated breeding strategies. To answer question, heterogeneous spring barley was established between wild an elite cultivar examine question. This initial...
A beneficial root system is crucial for efficient nutrient uptake and stress tolerance. Therefore, evaluating the variation breeding crop plants towards adaptation critically important. Here, we phenotyped architectural traits of naturally adapted populations from organic conventional cropping systems under hydroponic field trails. Long-term natural selection these two resulted in a microevolution morphological anatomical traits. Barley lines developed an possessed longer roots with narrow...
Orofacial clefts (OFC) present different phenotypes with a postnatal challenge for oral microbiota development. In order to investigate the impact of OFC on microbiota, smear samples from 15 neonates and 17 without were collected two niches (tongue, cheek) at time points, i.e. after birth (T0: Ø3d group; Ø2d control group) 4-5 weeks later (T1: Ø32d Ø31d group). Subsequently, analyzed using next-generation sequencing. We detected significant increase alpha diversity anaerobic Gram-negative...