Abstract Flowering time and plant height are two critical determinants of yield potential in barley (Hordeum vulgare). Despite their role physiological regulation, a complete overview the genetic complexity flowering regulation is still lacking. Using double round-robin population originated from crossings 23 diverse parental inbred lines, we aimed to determine variance components as well identify new variants by single multi-population QTL analyses allele mining. similar genotypic variance,...

Water scarcity is a critical threat to global crop production. Here, we used the natural diversity of barley (Hordeum vulgare) dissect genetic control proline (Pro) mediated drought stress adaptation. Genetic mapping and positional cloning major drought-inducible quantitative trait locus (QPro.S42-1H) revealed unique allelic variation in pyrroline-5-carboxylate synthase (P5cs1) between cultivated cultivar Scarlett (ssp. wild accession ISR42-8 spontaneum). The putative causative mutations...

Rising tropospheric ozone affects the performance of important cereal crops thus threatening global food security. In this study, genetic variation wheat regarding its physiological and yield responses to was explored by exposing a diversity panel 150 genotypes elevated control conditions throughout growing season. Differential were observed for foliar symptom formation quantified as leaf bronzing score (LBS), vegetation indices components. Vegetation representing carotenoid chlorophyll...

Proline accumulation is one of the major responses plants to many abiotic stresses. However, significance proline for drought stress tolerance remains enigmatic in crop plants. First, we examined natural variation pyrolline-5-carboxylate synthase (P5CS1) among 49 barley genotypes. Allele mining identified a previously unknown allelic series that showed polymorphisms at 42 cis-elements across P5CS1 promoter. Selected haplotypes had quantitative gene expression and accumulation, putatively...

Grain number, size and weight primarily determine the yield of barley. Although genes regulating grain number are well studied in barley, genetic loci causal gene for sink capacity poorly understood. Therefore, primary objective our work was to dissect architecture We used a multi-parent population developed from cross between 23 diverse barley inbreds double round-robin design. Seed size-related parameters such as length, width, area thousand-grain were evaluated HvDRR comprising 45...

Abstract Genes containing the SET domain can catalyse histone lysine methylation, which in turn has potential to cause changes chromatin structure and regulation of transcription genes involved diverse physiological developmental processes. However, functions domain-containing (StSET) potato still need be studied. The objectives our study summarized as silico analysis (i) identify StSET genome, (ii) systematically analyse gene structure, chromosomal distribution, duplication events, promoter...

Manganese (Mn) is an essential micro-nutrient for plants, but flooded rice fields can accumulate high levels of Mn2+ leading to Mn toxicity. Here, we present a genome-wide association study (GWAS) identify candidate loci conferring toxicity tolerance in (Oryza sativa L.). A diversity panel 288 genotypes was grown hydroponic solutions greenhouse under optimal and toxic concentrations. We applied treatment (5 ppm Mn2+, 3 weeks) at twelve days after transplanting. caused moderate damage terms...

In addition to heterogeneity and artificial selection, natural selection is one of the forces used combat climate change improve agrobiodiversity in evolutionary plant breeding. Accurate identification specific genomic effects will likely accelerate transfer between populations. Thus, insights into changes allele frequency, adequate population size, gene flow drift are essential. However, observing such often involves a trade-off costs resolution when large sample genotypes for many loci...

Genomic prediction (GP) based on single nucleotide polymorphisms (SNP) has become a broadly used tool to increase the gain of selection in plant breeding. However, using predictors that are biologically closer phenotypes such as transcriptome and metabolome may ability GP. The objectives this study were (i) assess for three yield-related phenotypic traits different omic datasets compared SNP array, where these included types sequence variants (full-SV, deleterious-dSV, tolerant-tSV),...

Abstract Proline is an important metabolite that plays adaptive role in plants under water‐deficit stress. Understanding the genetic basis of water‐deficit‐induced proline accumulation remains elusive crop plants, especially wheat. Here, we investigated control and conditions using a diversity panel which comprises 150 bread wheat cultivars. Water‐deficit stress significantly increased than well‐water treated plants. Water‐deficit‐induced variability was dissected genome‐wide association...

Abstract Drought stress alters the metabolic activity, physiological processes, and plant growth such responses might differ with intensity of stress. We evaluated genotypic diversity on morphology, photosynthetic responses, metabolite shift their relationship in diverse barley inbreds under dry down (DD) moderate drought (MD) using 23 genetically parental genetic mapping population barley. MD caused a strong reduction, while DD triggered inhibition health. observed that induced changes...

ABSTRACT Epigenetic variation contributes to explaining the missing heritability of complex traits. In order understand genome-wide methylation in spring barley, our objectives were gain fundamental insight into barley methylome through whole genome bisulfite sequencing, characterizing among 23 parental inbreds a community resource for genetic mapping phenotypic traits, and assessing association differentially methylated regions (DMRs) with single nucleotide polymorphisms (SNPs) gene...

ABSTRACT Flowering time and plant height are two critical determinants of yield potential in barley ( Hordeum vulgare ). Although their role as key traits, a comprehensive understanding the genetic complexity flowering regulation is still lacking. Through double round-robin population originated from crossings 23 diverse parental inbred lines, we aimed to determine variance components well identify new variants by single multi-population quantitative trait loci (QTL) analyses allele mining....

Breeding drought stress tolerance is an integral part of our current and future goals sustainable agricultural production. In the present study, we examined natural variation HvP5cs1 demonstrated utility a wild barley allele for adaptation in cultivated barley. Sequencing 5-end regulatory region among 49 accessions identified genetically distinct promoter from ISR42-8. Allele mining indicated quantitative proline accumulation which was associated with polymorphisms across cluster abscisic...

Crusted scabies causes extensive hyperkeratotic skin lesions, crusting, and scaling is common in elderly institutionalized patients.We present a case of crusted patient with encephalopathy diffuse exfoliative erythroderma.After workup, the patient's condition was attributed to hypereosinophilic syndrome due scabies.Skin condition, mental status, eosinophilia improved high-dose steroids conjunction topical permethrin oral ivermectin.

<title>Abstract</title> Genes containing the SET domain can catalyse histone lysine methylation, which in turn has potential to cause changes chromatin structure and regulation of transcription genes involved diverse physiological developmental processes. However, functions domain-containing (StSET) potato still need be studied. The objectives our study were (i) identify StSET genome, (ii) systematically analyse gene structure, chromosomal distribution, duplication events, promoter...

Abstract Grain number, size and weight primarily determine the yield of barley. Although genes regulating grain number are well studied in barley, genetic loci causal gene for sink capacity poorly understood. Therefore, primary objective our work was to dissect architecture We used a multi-parent population developed from cross between 23 diverse barley inbreds double round-robin design. Seed size-related parameters such as length, width, area thousand-grain were evaluated HvDRR comprising...

Introduction: Eosinophilic esophagitis (EoE) is a chronic and progressive type 2 inflammatory condition causing significant dysphagia impaired quality of life. In this review, we aim to study the contemporary prevalence EoE with gender, racial disparities as well other baseline characteristics over course four years. Methods: We used NIS database 2016-2019 identify patients eosinophilic using appropriate ICD-10 code (K20.0) which was analyzed STATA 17.0 software. evaluated prevalence,...

Introduction: The prevalence of Non-alcoholic fatty liver disease (NAFLD) has been increasing in the US and Steatohepatitis is most rapidly indication for a transplant. We evaluated burden, contemporary trends, baseline characteristics, overall mortality hospitalized patients with NAFLD using National Inpatient Sample (NIS) database. Methods: 2016-2019 NIS database was used to identify all adults (age >18) relevant ICD 10 codes K76.0, K75.81. Baseline characteristics including gender, racial...

Introduction: Hepatorenal syndrome (HRS) is a life-threatening complication of advanced cirrhosis with an 85% three-month mortality. However, the prevalence and mortality HRS in relation to different stages chronic kidney disease (CKD) are not well studied. Hence, we used data from 2019 National Inpatient Sample (NIS) database compare hospitalized patients across CKD. Methods: We utilized NIS identify all adult (>18 years) CKD (N18) (K76.7) using appropriate ICD-10-CM codes. categorized into...