A5100449607- Nutrition and Health in Aging
- Frailty in Older Adults
- Gastrointestinal motility and disorders
- Immune Cell Function and Interaction
- Pediatric Hepatobiliary Diseases and Treatments
- Meta-analysis and systematic reviews
- Neuropeptides and Animal Physiology
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Gut microbiota and health
- Acute Myeloid Leukemia Research
- Barrier Structure and Function Studies
- Mesenchymal stem cell research
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Congenital gastrointestinal and neural anomalies
- Diet and metabolism studies
- RNA Research and Splicing
- Retinal Imaging and Analysis
- Animal testing and alternatives
- Salivary Gland Tumors Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related gene regulation
In-Q-Tel
2025
Xuzhou Medical College
2025
Tianjin Children's Hospital
2024-2025
Xuzhou Central Hospital
2025
Lanzhou University
2011-2024
Shanxi Medical University
2023-2024
Guangxi Medical University
2024
First Hospital of Lanzhou University
2011-2024
Integrated Chinese Medicine (China)
2024
Tianjin University
2024
Abstract With the continuous improvement of human technology, medical field has gradually moved from molecular therapy to cellular therapy. As a safe and effective therapeutic tool, cell successfully created research boom in modern field. Mesenchymal stem cells (MSCs) are derived early mesoderm have high self-renewal multidirectional differentiation ability, become one important cores by virtue their immunomodulatory tissue repair capabilities. In recent years, application MSCs various...
Abstract Acute myeloid leukemia (AML) has a high rate of treatment failure due to increased prevalence therapy resistance. Mesenchymal stem cells (MSCs) in the microenvironment contribute chemoresistance AML, but specific mechanism remains unclear. The critical role epithelial–mesenchymal transition (EMT)‐like profile AML been gradually recognized. However, there is no research suggest that AML‐derived bone marrow mesenchymal (AML‐MSCs) induce EMT program thus far. We isolated AML‐MSCs and...
Abnormal coagulation is a common feature of glioma. There strong correlation between and the complement system, named cascades (CCC). However, role CCC genes in lower-grade glioma (LGG) remains unclear. This study aimed to investigate LGG.
Background One reason patients with cancer cannot benefit from immunotherapy is the lack of immune cell infiltration in tumor tissues. Cancer-associated fibroblasts (CAFs) are emerging as central players regulation that shapes microenvironment (TME). Earlier we reported integrin α5 was enriched CAFs colorectal (CRC), however, its role TME and remains unclear. Here, aimed to investigate for modulating antitumor immunity therapeutic efficacy combined checkpoint blockade CRC. Methods We...
Chemotherapy failure and resistance are the leading causes of mortality in patients with acute myeloid leukemia (AML). However, role m6A demethylase FTO its inhibitor rhein AML drug is unclear. Therefore, this study aimed to investigate antileukemic effect on explore potential mechanisms underlying resistance. Bone marrow fluid was collected assess expression AML. The Cell Counting Kit 8 reagent used cell viability. Migration assays were conducted migration capacity. Flow cytometry determine...
ABSTRACT Introduction Statins, a class of HMG‐CoA reductase inhibitors, exhibit prophylactic benefits against immune rejection induced by allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Despite the protective function is confirmed, precise mechanism to induce tolerance statin in initial stages remains incompletely understood. Given that Treg cells play critical role preventing graft versus host response and Foxp3 as transcription factor can be statins, we hypothesize...
Cerebral ischemia-reperfusion (IR) injury is a frequent complication of ischemic stroke with the adverse impact on clinical prognosis. This study focused molecular mechanism associated TEA domain transcription factor 1 (TEAD1) and matrix metalloproteinase 3 (MMP3) in cerebral IR. In vitro, IR model was established using oxygen-glucose deprivation/reoxygenation (OGD/R) human brain microvascular endothelial cells (HBMVECs). TEAD1 MMP3 mRNA protein examination were performed by RT-qPCR western...
Previous studies have found a reduction in butyrate-producing bacteria the gut microbiota of infants with biliary atresia (BA). Butyrate is also an important inhibitor histone deacetylase 2 (HDAC2). This study aims to explore how butyrate alleviates liver fibrosis BA through HDAC2. Fibrosis-related pathways associated were analyzed using GSE46960 database. sections used validate factor expression. The effects HDAC2 and pathway performed vitro experiments. intervention was bile duct ligation...
Resveratrol, a non-flavonoid polyphenolic compound, is structurally and functionally similar to estrogen has drawn great attention for its potentially beneficial effects on diabetes. However, it not known whether shares the same protective effect against diabetes as underlying mechanisms. The aim of present study was investigate phytoestrogen resveratrol exogenous 17β-estradiol streptozotocin (STZ)-induced type 1 Female mice were ovariectomized (OVX) chronically injected with different...
Elizabethkingia anophelis, originally isolated from the midgut of Anopheles gambiae in 2011, is an important cause sepsis adults and children meningitis newborns, with several reported outbreaks worldwide. Accumulating molecular biological whole-genome sequencing (WGS) evidence suggests that E. anophelis major human pathogen belonging to genus Elizabethkingia. The source infection, routes transmission pathogenicity are unclear should be better understood as bacterium capable causing...
Vorinostat (SAHA) is the first HDACs inhibitor approved by FDA for treatment of cutaneous T-cell lymphoma, and broad-spectrum inhibitory activities towards HDAC families make SAHA exhibit great therapeutic potential. However, drawbacks associated with hydroxamic acid group (poor stability, easy metabolism, weak binding ability to class Ⅱa isozymes, poor selectivity) have been exposed during process continuous clinical application, making discovery inhibitors novel zinc (ZBG) more necessary....
Destruction of the intestinal mucosal barrier and visceral hypersensitivity are main pathogenesis irritable bowel syndrome (IBS). The study aimed to establish a rat model explore mechanisms involved changes protein expression flora.A was established evaluated using abdominal withdrawal reflex (AWR) scores, colonic paracellular permeability, gastrointestinal motility. tight junction proteins, aquaporin proteins (AQPs), phosphorylated ERK, proteinase-activated receptor-2 (PAR-2) determined....