A5101609471- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cell Adhesion Molecules Research
- Heart Rate Variability and Autonomic Control
- Cardiac pacing and defibrillation studies
- Ion channel regulation and function
- Cardiovascular Function and Risk Factors
- Vagus Nerve Stimulation Research
- Thyroid Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- ECG Monitoring and Analysis
- Particle physics theoretical and experimental studies
- Cardiac Imaging and Diagnostics
- Quantum Chromodynamics and Particle Interactions
- Cardiovascular Syncope and Autonomic Disorders
- Retinal Diseases and Treatments
- High-Energy Particle Collisions Research
- Glaucoma and retinal disorders
- Adipose Tissue and Metabolism
- Cardiomyopathy and Myosin Studies
- Immune cells in cancer
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Pediatric Hepatobiliary Diseases and Treatments
Cleveland Clinic
2007-2024
Shanghai Tenth People's Hospital
2018-2024
Tongji University
2016-2024
Institute of High Energy Physics
2020-2023
New York Institute of Technology
2014-2023
Liuzhou General Hospital
2023
Chinese Academy of Sciences
2013-2021
University of Chinese Academy of Sciences
2019-2021
Center for Excellence in Molecular Cell Science
2013-2021
Texas Tech University Health Sciences Center
2017
Background— Autonomic dysfunction, characterized by sympathetic activation and vagal withdrawal, contributes to the progression of heart failure (HF). Although therapeutic benefits inhibition with β-blockers in HF are clear, role increased tone this setting has been less studied. We have investigated impact enhancing (achieved through chronic cervical vagus nerve stimulation, [VNS]) on development a canine high-rate ventricular pacing model. Methods Results— Fifteen dogs were randomized into...
Abstract Introduction Environmental stimulus, especially noise and light, is thought to disrupt sleep in patients the intensive care unit (ICU). This study aimed determine physiological psychological effects of ICU earplugs eye masks, used these conditions healthy subjects. Methods Fourteen subjects underwent polysomnography under four conditions: adaptation, baseline, exposure recorded light (NL), NL plus use masks (NLEE). Urine was analyzed for melatonin cortisol levels. Subjects rated...
Abstract Introduction Intensive care unit (ICU) environmental factors such as noise and light have been cited important causes of sleep deprivation in critically ill patients. Previous studies indicated that using earplugs eye masks can improve REM healthy subjects simulated ICU environment, quality This study aimed to determine the effects with relaxing background music on sleep, melatonin cortisol levels Methods Fifty patients who underwent a scheduled cardiac surgery were expected stay at...
Objectives: The aims of this study were to demonstrate the safety and feasibility robotic catheter remote control system (CCS) in endocardial navigation all cardiac chambers, as well facilitation transseptal puncture. Background: CCS has been developed facilitate precise positioning catheters within cardiovascular system. Methods: consists a manipulator, set up joint, physician workstation, steerable guide (SGC) sheath. A conventional 4‐mm tip was inserted through SGC perform mapping five...
Evidence indicates that cardiac hypothyroidism may contribute to heart failure progression. It is also known associated with an increased risk of atrial fibrillation (AF). Although it established hyperthyroidism increases AF incidence, the effect on unclear. This study investigated effects different thyroid hormone levels, ranging from inducibility in thyroidectomized rats.Thyroidectomized rats serum-confirmed 1 month after surgery were randomized into hypothyroid (N=9), euthyroid and...
Abstract Disrupted gastrointestinal (GI) motility is highly prevalent in patients with inflammatory bowel disease (IBD), but its potential causative role remains unknown. Herein, the and mechanism of impaired GI colitis pathogenesis are investigated. Increased colonic mucosal inflammation found chronic constipation (CC). Mice dysmotility induced by genetic mutation or chemical insult exhibit increased susceptibility to colitis, dependent on gut microbiota. markedly decreases abundance...
Autonomic denervation may suppress atrial fibrillation (AF) vulnerability. This study was designed to assess the short- mid-term effects of botulinum toxin, a cholinergic neurotransmission blocker, on AF inducibility.A total 23 mongrel dogs were studied. The sinus node and atrioventricular epicardial fat pads exposed through right lateral thoracotomy. Botulinum toxin (Botox, 50 U per pad) or 0.9% normal saline (control) injected into center each 2 pads. electrophysiological evaluated at 1,...
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-associated liver disease with potentially deleterious consequences for the fetus, particularly when maternal serum bile-acid concentration >40 μM. However, etiology and pathogenesis ICP remain elusive. To reveal underlying molecular mechanisms association level fetal outcome in patients, DNA microarray was applied to characterize whole-genome expression profiles placentas from healthy women diagnosed ICP. Thirty pregnant recruited...
piRNA-823 as a member of the piRNA family is reported to promote tumour cell proliferation in multiple myeloma and hepatocellular cancer. However, few studies on function colorectal cancer (CRC). Our present study data showed that plays an oncogene role CRC cells. Inhibition can significantly inhibit proliferation, invasion apoptosis resistance Mechanism have shown inhibits ubiquitination hypoxia-inducible factor-1 alpha (HIF-1α) by up-regulating expression Glucose-6-phosphate dehydrogenase...
Cardiac sympathetic activation, mediated by β-adrenergic receptors (β-ARs), normally increases cardiac contraction and relaxation. Accomplishing this task requires a physiological, concerted Ca 2+ signaling, being able to increase release from sarcoplasmic reticulum (SR) in systole speed up re-uptake diastole. In heart failure (HF) myocardial β-ARs undergo desensitization/down-regulation due sustained adrenergic activation. β-AR diminishes signaling contractile reserve, is conventionally...
Background A large body of evidence suggests that thyroid hormones (THs) are beneficial for the treatment cardiovascular disorders. We have shown 3 days triiodo-L-thyronine (T3) in myocardial infarction (MI) rats increased left ventricular (LV) contractility and decreased myocyte apoptosis. However, no clinically translatable protocol is established T3 ischemic heart disease. hypothesized low-dose oral will offer safe therapeutic benefits MI. Methods Results Adult female underwent coronary...
Reperfusion injury following acute myocardial infarction is associated with significant morbidity. Activation of neuronal or non-neuronal cholinergic pathways in the heart has been shown to reduce ischemic injury, and this effect attributed primarily muscarinic acetylcholine receptors. In contrast, role nicotinic receptors, specifically α-7 subtype (α7nAChR), myocardium remains unknown, which offers an opportunity potentially repurpose several agonists/modulators that are currently under...
Intrahepatic cholestasis of pregnancy (ICP) is a cholestatic disorder with potentially deleterious consequences for fetuses. Although clear correlation between the elevated levels maternal serum bile acids and deficient fetal outcome has been established in clinical practice, underlying mechanisms remain elusive. Herein, we report that induce NF-κB pathway activation via G protein-coupled acid receptor 1 (Gpbar1), consequent upregulation inflammatory genes trophoblasts, leading to aberrant...
ABSTRACT We report on the Insight-HXMT observations of new black hole X-ray binary MAXI J1820+070 during its 2018 outburst. Detailed spectral analysis via continuum fitting method shows an evolution inferred spin high soft sate. Moreover, hardness ratio, non-thermal luminosity and reflection fraction also undergo evolution, exactly coincident to period when transition takes place. The unphysical is attributed inner disc, which caused by collapse a hot corona due condensation mechanism or may...
Background One reason patients with cancer cannot benefit from immunotherapy is the lack of immune cell infiltration in tumor tissues. Cancer-associated fibroblasts (CAFs) are emerging as central players regulation that shapes microenvironment (TME). Earlier we reported integrin α5 was enriched CAFs colorectal (CRC), however, its role TME and remains unclear. Here, aimed to investigate for modulating antitumor immunity therapeutic efficacy combined checkpoint blockade CRC. Methods We...
Overconsumption of a diet rich in fat and carbohydrates, called the Western diet, is major contributor to global epidemic cardiovascular disease. Despite previously documented protection exhibited female rats, this safeguard may be lost under certain metabolic stressors. We hypothesized that Wistar rats challenged by composed 21% 50% carbohydrate (34.1% sucrose) for 17 wk would develop endothelial dysfunction via Toll-like receptor 4 (TLR4) signaling. diet-fed dysregulation metabolism,...
Abstract One question in lymphocyte homing is how integrins are rapidly activated to enable immediate arrest of fast rolling lymphocytes upon encountering chemokines at target vascular beds given the slow chemokine-induced integrin inside-out activation. Herein we demonstrate that chemokine CCL25-triggered Ca 2+ influx induces T cell membrane-proximal external concentration ([Ca ] ex ) drop 6 s from physiological 1.2 mM 0.3 mM, a critical extracellular threshold for inducing αLβ2 activation,...
Background— Selective atrioventricular nodal (AVN) vagal stimulation (AVN-VS) has emerged as a novel strategy for ventricular rate (VR) control in atrial fibrillation (AF). Although AVN-VS preserves the physiological activation sequence, resulting is slow but irregular. In contrast, AVN ablation with pacemaker implantation produces retrograde (starting at apex), regular rhythm. We tested hypothesis that, comparable levels of VR slowing, provides hemodynamic benefits similar to those...