A5082727410- RNA Interference and Gene Delivery
- Nicotinic Acetylcholine Receptors Study
- Cancer Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Eosinophilic Esophagitis
- Neuroscience and Neuropharmacology Research
- Antifungal resistance and susceptibility
- Plant Disease Resistance and Genetics
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Vascular Malformations Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Cardiac tumors and thrombi
- Plant Pathogens and Fungal Diseases
- Eicosanoids and Hypertension Pharmacology
- Organ Transplantation Techniques and Outcomes
- Peptidase Inhibition and Analysis
- Neurosurgical Procedures and Complications
- Transplantation: Methods and Outcomes
- Vagus Nerve Stimulation Research
- Sarcoma Diagnosis and Treatment
- Receptor Mechanisms and Signaling
- Renal Transplantation Outcomes and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Fungal Infections and Studies
Northwell Health
2015-2019
Lenox Hill Hospital
2017-2019
Hofstra University
2015-2017
North Shore University Hospital
2015
The University of Texas Health Science Center at San Antonio
2015
AF102B [(+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine], a structurally rigid analog of acetylcholine, was investigated in number neurochemical, pharmacological and behavioral tests related to cholinergic functions. induced atropine-sensitive contractions isolated guinea pig ilea trachea preparations with EC50 values 3.5 3 microM being 87- 1.3-fold less potent than respectively. Binding studies using the radioligands pirenzepine, cis-dioxolane quinuclidinyl benzilate rat cerebral...
Reperfusion injury following acute myocardial infarction is associated with significant morbidity. Activation of neuronal or non-neuronal cholinergic pathways in the heart has been shown to reduce ischemic injury, and this effect attributed primarily muscarinic acetylcholine receptors. In contrast, role nicotinic receptors, specifically α-7 subtype (α7nAChR), myocardium remains unknown, which offers an opportunity potentially repurpose several agonists/modulators that are currently under...
Primary splenic angiosarcoma carries a poor prognosis and is among the rarest forms of malignancy. An overwhelming majority patients with will develop metastases. However, osseous metastatic disease rare. We present an 83 year old hispanic female who was diagnosed primary on bone marrow biopsy performed for hematologic workup. highlight key historical, laboratory, imaging, pathological features angiosarcoma. The synthesis both imaging clinical history essential establishing early diagnosis...
Primary squamous cell carcinoma of the gallbladder is a rare entity that comprises approximately 1%-3% all primary cancers. We report case 37-year-old woman who was diagnosed with locally invasive gallbladder. Surgical pathology revealed predominantly composition tumor few microscopic foci adenocarcinoma (<1% tumor). discuss pertinent clinical features, risk factors, and imaging characteristics to prompt early diagnosis treatment, which will ultimately lead improved patient outcomes.
Phaeohyphomycosis is an uncommon mycotic infection caused by dematiaceous fungi. We report a 53-year-old male who presented with phaeohyphomycosis on his upper extremities, 6 months after renal transplantation. Biopsy revealed pigmented moniliform hyphae and cultures grew Exophiala oligosperma. The lesions completely resolved 3 of treatment posaconazole.
Pancreatic cancer is the most common lethal cancer, with annual incidence and mortality rates being approximately equal. This dismal prognosis can be attributed to late diagnosis making cancers unresectable. These respond poorly chemotherapy radiation, surgical resection remains effective treatment available. Diagnostic tests that are sensitive, specific, capable of early detection urgently needed would significantly impact upon pancreatic outcomes. Exosomes, small membrane-bound vesicles...