A5088202880- Platelet Disorders and Treatments
- Venomous Animal Envenomation and Studies
- Astrophysical Phenomena and Observations
- Pulsars and Gravitational Waves Research
- Cell Adhesion Molecules Research
- Gamma-ray bursts and supernovae
- Blood properties and coagulation
- Biochemical and Structural Characterization
- Streptococcal Infections and Treatments
- Acute Myeloid Leukemia Research
- Astrophysics and Cosmic Phenomena
- Neurofibromatosis and Schwannoma Cases
- Schizophrenia research and treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- Toxin Mechanisms and Immunotoxins
- Orthopaedic implants and arthroplasty
- Blood Coagulation and Thrombosis Mechanisms
- Bone Tissue Engineering Materials
- Bone Tumor Diagnosis and Treatments
- Blood transfusion and management
- Eosinophilic Esophagitis
- Blood groups and transfusion
- Mechanics and Biomechanics Studies
- Retinal and Macular Surgery
Tzu Chi University
2008-2025
University College London
2021-2023
Royal National Orthopaedic Hospital
2021-2023
Beijing Institute of Technology
2023
Institute of High Energy Physics
2020-2022
Chinese Academy of Sciences
2020-2022
Tri-Service General Hospital
2016
Yuli Hospital
2016
National Defense Medical Center
2016
Experimental Pathology Laboratories
2004
A straightforward method for the rapid detection of presence glutathione S-transferase (GST)-tagged proteins from sample solutions using (GSH)-bound gold nanoclusters (Au@GSH NCs) with luminescence properties as probes by simple observation naked eye was proposed in this study.
To improve the treatment effect of bone defect repair, titanium scaffolds having graded structures with porosities 78.8%, 70.8%, 62.6%, and 54.4% (denoted as P1, P2, P3, P4, respectively) were designed fabricated by selective laser melting. The manufacturability, microstructure, mechanical properties, permeability investigated theoretically experimentally. Simulation results showed that maximum von Mises stress in range 569.1–1469.0 MPa (21.7–54.6)×10−9 m2 respectively. Thereinto, P3 P4...
A potent platelet aggregation inducer, aggretin, was purified from Malayan-pit-viper (Calloselasma rhodostoma) venom by ionic-exchange chromatography, gel-filtration chromatography and HPLC. It is a heterodimeric protein (29 kDa) devoid of esterase, phospholipase thrombin-like activity. Aggretin (> 5 nM) elicited with lag period in both human platelet-rich plasma washed suspension. EDTA (5 mM), prostaglandin E1 (1 microM) 3,4,5-trimethoxybenzoic acid 8-(diethylamino)octyl ester ('TMB-8'; 100...
ABSTRACT We report on the Insight-HXMT observations of new black hole X-ray binary MAXI J1820+070 during its 2018 outburst. Detailed spectral analysis via continuum fitting method shows an evolution inferred spin high soft sate. Moreover, hardness ratio, non-thermal luminosity and reflection fraction also undergo evolution, exactly coincident to period when transition takes place. The unphysical is attributed inner disc, which caused by collapse a hot corona due condensation mechanism or may...
Nitric oxide (NO) is identified as the endothelium-derived relaxing factor and a neurotransmitter with superfusion bioassay cascade technique. By using similar technique rat superior cervical ganglion (SCG) donor tissue rabbit endothelium-denuded aortic ring detector tissue, we report here that vasodilator, which more potent than NO, released in SCG upon field electrical stimulation (FES) or addition of nicotine. Release this vasodilator was enhanced by arginine analogs, including...
The High Energy X-ray telescope (HE) on-board the Hard Modulation Telescope (\textit{Insight}-HXMT) can serve as a wide Field of View (FOV) gamma-ray monitor with high time resolution ($\mu$s) and large effective area (up to thousands cm$^2$). We developed pipeline search for Gamma-Ray Bursts (GRBs), using traditional signal-to-noise ratio (SNR) method blind coherent targeted search. By taking into account location spectrum burst detector response, is more powerful unveil weak sub-threshold...
Summary Clumping factor A (ClfA) is a surface of protein Staphylococcusaureus bacteria known for its ability to bind the C-terminus plasma fibrinogen γ chain, which participates in mediating fibrinogen- platelet interaction and fibrin cross-linking, resulting thrombus formation. With an aim develop agents that block chain C-terminus,the fibrinogen-binding segment ClfA locating at residues 221–550 was produced by recombinant technology tested inhibit functions clot Recombinant ClfA221–550...
The efficacy of clozapine clearance has been shown to be associated with smoking and genetic polymorphism CYP1A2. This study aims investigate the effect on plasma level in Taiwanese schizophrenic patients its relevance CYP1A2 gene -163A/C single nucleotide polymorphism.A total 143 hospitalized who had received therapy for at least 14 days were enrolled this study. trough concentration was measured LC/MS/MS. variant identified by DNA sequencing restriction fragment length analysis. examined...
ABSTRACT We studied the 2018 outburst of black hole transient H 1743 − 322 with a series Insight-HXMT, NICER, and NuSTAR observations, covering 1–120 keV band. With our broad-band X-ray spectral modelling, we confirm that source remained in low/hard state throughout month-long outburst, although it became marginally softer at peak flux. detected Type-C quasi-periodic oscillations (QPOs) followed evolution their properties. The QPO frequency increased from ∼0.1 to ∼0.4 Hz during rising phase...
ABSTRACT Based on Insight-HXMT data, we report the pulse fraction evolution during 2017–2018 outburst of newly discovered first Galactic ultraluminous X-ray (ULX) source Swift J0243.6+6124. The fractions 19 observation pairs selected in rising and fading phases with similar luminosity are investigated. results show a general trend increasing energy at supercritical luminosity. However, relative strength pulsation between each pair evolves strongly phase is larger below 7.71 × 1038 erg s−1,...
The blockade of platelet membrane glycoprotein IIb/IIIa by a monoclonal antibody, 7E3, was measured flow cytometry using fluorescein isothiocyanate-conjugated disintegrin, FITC-crotavirin, as the probe. After treatment platelets with 7E3 or F(ab')2, there is good correlation between inhibition aggregation and FITC-crotavirin's binding to platelets. content for subsequent FITC-crotavirin 7E3-pretreated highly correlated extent IIb/IIIa, remaining available. It evidenced observation that sum...
Coronavirus disease 2019 (COVID-19) vaccines are associated with serious thromboembolic or thrombocytopenic events including vaccine-induced immune thrombocytopenia and thrombosis thrombocytopenia, particularly AZD1222/ChAdOx1. According to the proposed mechanism, COVID-19 stimulate inflammation platelet activation. In this study, we analyzed role of AZD1222/ChAdOx1 in activation platelets release anti-PF4 antibodies inflammatory cytokines a cohort healthy donors without thrombotic (VITT)....
Granulocyte colony-stimulating factor (G-CSF) is now widely used in patients with malignant disorders receiving intensive chemotherapy to increase leukocyte count and upregulate phagocyte function during neutropenia. Monocytosis associated G-CSF has been reported anecdotal literature. We report two cases of pseudoleukemia secondary administration. Both initially presented myelodysplastic syndrome chromosome 7 abnormalities that evolved into acute myeloid leukemia. Case one had deletion 7q...
We report on our analysis of the 2019 outburst X-ray accreting pulsar 4U 1901+03 observed with Insight-HXMT and NICER. Both spectra pulse profiles evolve significantly in decaying phase outburst. Dozens flares are throughout They more frequent brighter at peak. find that flares, which have a duration from tens to hundreds seconds, generally than persistent emission by factor $\sim$ 1.5. The profile shape during can be different emission. In particular, shift is clearly many cases. interpret...
Summary Disintegrins are a group of snake venom peptides which inhibit human platelet aggregation by acting as glycoprotein Ilb-IIIa (GPIIb-Ilia) antagonists. They cysteine-rich, Arg-Gly-Asp (RGD)-containing peptides, and bind to GPIIb-Ilia complex on membrane with very high affinity (Kd, 10−7 ∼ 10−8 M). In this study, we analyzed flow cytometry using fluorescein isothiocyanate (FITC)-conjugated disintegrins probes. Of these FITC-conjugated disintegrins, FITC-Rhodostomin is the most...
The therapeutic effect of methylphenidate (MPH) in treating attention-deficit/hyperactivity disorder (ADHD) has been related to the alpha-2A adrenergic receptor (ADRA2A) gene -1291C/G single nucleotide polymorphism (SNP). We investigated MPH Taiwanese children and adolescent with ADHD its relation ADRA2A SNP. subjects DSM-IV diagnosis underwent a titration period find out dose for maintenance treatment. After 4 weeks treatment, was evaluated by Swanson, Nolan Pelham version IV total scores....
Abstract Background and Aim Secondary peristalsis contributes to the clearance of retained refluxate from esophagus. Sildenafil, a phosphodiesterase‐5 inhibitor, inhibits primary esophageal peristalsis, but its effects on secondary remain unknown. This study sought investigate whether sildenafil could influence physiological characteristics by applying high‐resolution manometry (HRM). Methods Seventeen healthy volunteers (15 men 2 women, aged 30.2 ± 6.4 years) underwent two HRM studies...