A5045022912- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neuropharmacology Research
- Cardiac Ischemia and Reperfusion
- Cardiac Arrest and Resuscitation
- Neurological Disease Mechanisms and Treatments
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disorders and Treatments
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- S100 Proteins and Annexins
- Eicosanoids and Hypertension Pharmacology
- Fatty Acid Research and Health
- Biochemical effects in animals
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer-related gene regulation
- Memory and Neural Mechanisms
- Acute Ischemic Stroke Management
- Hemoglobinopathies and Related Disorders
- Neonatal and fetal brain pathology
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- Nitric Oxide and Endothelin Effects
- Sirtuins and Resveratrol in Medicine
The University of Texas Health Science Center at Houston
2024-2025
Louisiana State University Health Sciences Center Shreveport
2016-2024
Mater Health Services
2018
Louisiana State University Health Sciences Center New Orleans
2018
Princess Alexandra Hospital
2018
University of Miami
2008-2016
Alzheimer's disease (AD) is the most common form of dementia in elderly, causing neuronal degeneration and cognitive deficits that significantly impair independence quality life for those affected their families.Though AD a major neurodegenerative with vast avenues investigation, there no effective treatment to cure or slow progression.The present work evaluated therapeutic effect long-term photobiomodulation (PBM) continuous-wave low-level laser on its underlying mechanism.Methods: PBM was...
Cardiopulmonary arrest is a leading cause of death and disability in the United States that usually occurs aged population. Cardiac (CA) induces global ischemia, disrupting cerebral circulation results ischemic brain injury leads to cognitive impairments survivors. Ischemia-induced neuronal damage hippocampus following CA can result impairment function including spatial memory. In present study, we used model asphyxial (ACA) nine month old male Fischer 344 rats investigate synaptic deficits...
Numerous epidemiological studies have reported a link between low testosterone levels and an increased risk of cerebrovascular disease in men. However, there is ongoing controversy surrounding replacement therapy due to potential side effects. PBMT has been demonstrated improve function promote synthesis peripheral tissues. Despite this, the molecular mechanisms that could connect with vascular brain photothrombosis (PT)-induced stroke rats remain largely unknown.
Background The release of cytochrome c from the mitochondria following cerebral ischemia is a key event leading to cell death. goal present study was determine mechanisms involved in post-ischemic activation protein kinase delta (δPKC) that lead release. Methods/Findings We used rat model cardiac arrest as an vivo model, and vitro analog, oxygen glucose deprivation (OGD) hippocampal synaptosomes. Cardiac triggered translocation δPKC mitochondrial fraction at 1 h reperfusion. In synaptosomes,...
Delayed neuroprotection against ischemic challenges is conferred by both preconditioning (IPC) and activation of the ε-isoform protein kinase C (εPKC-PC). In vivo, enhances GABA release ameliorates glutamate during lethal cerebral ischemia. We tested hypothesis that IPC εPKC-PC confer synapses in rat organotypic hippocampal slices. Ischemic or was induced with 15 mins oxygen-glucose deprivation (OGD) ψεRACK, a selective εPKC activator; test ischemia consisted 40 OGD. At time peak (48 h after...
Background: Evaluating mild to moderate cognitive impairment in a global cerebral ischemia (i.e. cardiac arrest) model can be difficult due poor locomotion after surgery. For example, rats who undergo surgical procedures and are subjected the Morris water maze may not able swim, thus voiding experiment. New Method: We established modified behavioral spontaneous alternation T-maze test. The major advantage of protocol is its relatively simple design that powerful enough assess functional...
Nitric oxide (NO) is identified as the endothelium-derived relaxing factor and a neurotransmitter with superfusion bioassay cascade technique. By using similar technique rat superior cervical ganglion (SCG) donor tissue rabbit endothelium-denuded aortic ring detector tissue, we report here that vasodilator, which more potent than NO, released in SCG upon field electrical stimulation (FES) or addition of nicotine. Release this vasodilator was enhanced by arginine analogs, including...
Sympathetic nervous system activity is increased after cardiopulmonary arrest, resulting in vasoconstrictor release from the perivascular sympathetic nerves of cerebral arteries. However, pathophysiological function ischemic brain remains unclear. A rat model global ischemia (asphyxial cardiac ACA) was used to investigate arteries via bilateral decentralization (preganglionic lesion) superior cervical ganglion (SCG). Decentralization SCG 5 days before ACA alleviated hypoperfusion and...
Abstract Alzheimer's disease (AD) is the leading cause of mortality, disability, and long‐term care burden in United States, with women comprising majority AD diagnoses. While AD‐related dementia associated tau amyloid beta accumulation, concurrent derangements cerebral blood flow have been observed alongside these proteinopathies humans rodent models. The homeostatic production nitric oxide synthases (NOS) becomes uncoupled which leads to decreased NO‐mediated vasodilation oxidative stress...
Background: Evaluating mild to moderate cognitive impairment in a global cerebral ischemia (i.e. cardiac arrest) model can be difficult due poor locomotion after surgery. For example, rats who undergo surgical procedures and are subjected the Morris water maze may not able swim, thus voiding experiment. New Method: We established modified behavioral spontaneous alternation T-maze test. The major advantage of protocol is its relatively simple design that powerful enough assess functional...
Abstract Protein arginine methyltransferases (PRMTs) are a family of enzymes involved in gene regulation and protein/histone modifications. PRMT8 is primarily expressed the central nervous system, specifically within cellular membrane synaptic vesicles. Recently, has been described to play key roles neuronal signaling such as regulator dendritic arborization, function maturation, differentiation plasticity. Here, we examined role response hypoxia‐induced stress brain metabolism. Our results...