A5059729786- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Anesthesia and Neurotoxicity Research
- Stress Responses and Cortisol
- Laser Applications in Dentistry and Medicine
- Adipose Tissue and Metabolism
- Hydrogen's biological and therapeutic effects
- Mitochondrial Function and Pathology
- Neurogenesis and neuroplasticity mechanisms
- Vitamin D Research Studies
- Telomeres, Telomerase, and Senescence
- Nuclear Receptors and Signaling
- Apelin-related biomedical research
- Spaceflight effects on biology
- Migraine and Headache Studies
- Neuroscience and Neuropharmacology Research
- Immune cells in cancer
- Neonatal and fetal brain pathology
- Vitamin C and Antioxidants Research
- Medical and Biological Ozone Research
- Biochemical effects in animals
- Medicinal Plants and Bioactive Compounds
- Traumatic Brain Injury and Neurovascular Disturbances
- Autism Spectrum Disorder Research
South China Normal University
2018-2025
Louisiana State University Health Sciences Center Shreveport
2022
Augusta University
2017-2022
Sichuan University
2008
West China Hospital of Sichuan University
2008
Baylor College of Medicine
2001
Alzheimer's disease (AD) is the most common form of dementia in elderly, causing neuronal degeneration and cognitive deficits that significantly impair independence quality life for those affected their families.Though AD a major neurodegenerative with vast avenues investigation, there no effective treatment to cure or slow progression.The present work evaluated therapeutic effect long-term photobiomodulation (PBM) continuous-wave low-level laser on its underlying mechanism.Methods: PBM was...
Background: Alzheimer's disease (AD), one of the most common forms dementia, is a widely studied neurodegenerative characterized by Aβ accumulation and tau hyperphosphorylation. Currently, there no effective cure available for AD.The astrocyte AQP4 polarized distribution-mediated glymphatic system essential abnormal clearance potential therapeutic target AD.However, role exercise on distribution association between phenotype polarization are poorly understood.Methods: Using streptozotocin...
This study aimed to examine the effects of swimming exercise pretreatment on a streptozotocin (STZ)-induced sporadic Alzheimer's disease (AD) rat model and provide an initial understanding related molecular mechanisms.Male 2.5-month-old Sprague-Dawley rats were divided into following four groups: (a) control, (b) swim + vehicle, (c) STZ without swim, (d) STZ. The Barnes maze task novel object recognition test used measure hippocampus-dependent spatial learning working memory, respectively....
Hypoxic-ischemic (HI) encephalopathy is a leading cause of dire mortality and morbidity in neonates. Unfortunately, no effective therapies have been developed as yet. Oxidative stress plays critical role pathogenesis progression neonatal HI. Previously, Nrf2 activator, tert-butylhydroquinone (TBHQ) has demonstrated to exert neuroprotection on brain trauma ischemic stroke models, well oxidative stress-induced cytotoxicity neurons. It is, however, still unknown whether TBHQ administration can...
Repeated closed-head injuries (rCHI) from activities like contact sports, falls, military combat, and traffic accidents pose a serious risk due to their cumulative impact on the brain. Often, rCHI is not diagnosed until symptoms of irreversible brain damage appear, highlighting need for preventive measures. This study assessed prophylactic efficacy remote photobiomodulation (PBM) targeted at lungs against rCHI-induced injury associated behavioral deficits. Utilizing "Marmarou" weight-drop...
Declining levels of physical activity and fitness in children youth are linked to negative health outcomes. This study investigates whether maternal exercise can enhance offspring's fitness. Our results demonstrate that improves endurance by changing muscle fiber composition promoting mitochondrial biogenesis, with benefits lasting across generations. improvement is associated changes DNA methylation, specifically the demethylation Slc23a2 gene, which codes for SVCT2, crucial vitamin C (VC)...
Abstract Background The role of proximal tubular autophagy in repairing kidney injury following ischemia remains unclear. Methods In this study, we utilized mice with conditional deletion the Atg5 gene tubules and monitored long-term dynamic regulation ischemic acute (AKI). Results results showed that -deficient tubule epithelial cells exhibited damaged mitochondria, concentric membranes, lysosomal accumulation 24 h after ischemia/reperfusion. However, 28 days ischemia/reperfusion, membrane...