A5101586209- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Drug Transport and Resistance Mechanisms
- Retinoids in leukemia and cellular processes
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural product bioactivities and synthesis
- Amino Acid Enzymes and Metabolism
- RNA regulation and disease
- Photoreceptor and optogenetics research
- Ocular Oncology and Treatments
- Pharmacological Effects and Toxicity Studies
- RNA and protein synthesis mechanisms
- Ginkgo biloba and Cashew Applications
- Trace Elements in Health
- Bacterial Genetics and Biotechnology
- Mesenchymal stem cell research
- Retinal Imaging and Analysis
- Single-cell and spatial transcriptomics
- FOXO transcription factor regulation
- Immune Cell Function and Interaction
- Glaucoma and retinal disorders
- MicroRNA in disease regulation
- Asthma and respiratory diseases
- Traditional Chinese Medicine Analysis
- Cancer-related molecular mechanisms research
The University of Sydney
2016-2025
Huazhong University of Science and Technology
2024-2025
Central Hospital of Wuhan
2024-2025
South China Normal University
2023-2025
Fujian Medical University
2003-2024
Wuhan University of Technology
2021-2024
Gannan Normal University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
The George Institute for Global Health
2022
Central South University
2007-2021
Müller cells are the major glia of retina that serve numerous functions essential to retinal homeostasis, yet contribution glial dysfunction diseases remains largely unknown. We have developed a transgenic model using portion regulatory region retinaldehyde binding protein 1 gene for conditional cell ablation and consequences primary been studied in adult mice. found selective led photoreceptor apoptosis, vascular telangiectasis, blood–retinal barrier breakdown and, later, intraretinal...
Toxin-antitoxin (TA) systems on the chromosomes of free-living bacteria appear to facilitate cell survival during intervals stress by inducing a state reversible growth arrest. However, upon prolonged stress, TA toxin action leads death. They have been implicated in several clinically important phenomena--bacterial persistence antibiotic treatment, biofilm formation and bacterial pathogenesis--and serve as attractive new targets for pathogens. We determined mode YafQ DinJ-YafQ system....
In Escherichia coli, programmed cell death is mediated through the system called "addiction module," which consists of a pair genes encoding stable toxin and labile antitoxin. The pemI-pemK an addiction module present on plasmid R100. It helps to maintain by post-segregational killing in E. coli population. Here we demonstrate that purified PemK, encoded module, inhibits protein synthesis cell-free system, whereas addition PemI, antitoxin against resumes synthesis. Further studies reveal...
Summary mRNA interferases are sequence‐specific endoribonucleases encoded by toxin‐antitoxin (TA) systems in bacterial genomes. Previously, we demonstrated that Mycobacterium tuberculosis contains at least seven genes encoding MazF homologues (MazF‐mt1 to ‐mt7) and determined cleavage specificities for MazF‐mt1 MazF‐mt6. Here have developed a new general method the determination of recognition sequences longer than three bases with use phage MS2 RNA as substrate CspA, an chaperone, which...
ABSTRACT Escherichia coli mRNA interferases, such as MazF and ChpBK, are sequence-specific endoribonucleases encoded by toxin-antitoxin (TA) systems present in its genome. A homologue Staphylococcus aureus (MazF Sa ) has been shown to inhibit cell growth when induced E. . Here, we determined the cleavage site for with use of phage MS2 RNA a substrate CspA, an chaperone, which prevents formation secondary structures substrate. specifically cleaves at pentad sequence, U↓ACAU. Bioinformatics...
ABSTRACT Gallic acid (GA), a polyhydroxylphenolic compound abundantly distributed in plants, fruits, and foods, has been reported to have various biological activities including an anticancer effect. In this study, we extensively investigated the effect of GA human breast carcinoma MCF‐7 cells. Our study indicated that treatment with resulted inhibition proliferation induction apoptosis Then, molecular mechanism GA's apoptotic action cells was further investigated. The results revealed...
Polymyxins are a last-line therapy to treat MDR Gram-negative bacterial infections. Nephrotoxicity is the dose-limiting factor for polymyxins and recent studies demonstrated significant accumulation of in renal tubular cells. However, little known about mechanism polymyxin uptake into these Oligopeptide transporter 2 (PEPT2) solute carrier (SLC) expressed at apical membrane proximal cells facilitates drug reabsorption kidney. In this study, we examined role PEPT2 We investigated inhibitory...
Abstract Amyloid β (Aβ)‐induced chronic inflammation is believed to be a key pathogenic process in early‐stage age‐related macular degeneration (AMD). Nucleotide oligomerization domain (NOD)‐like receptor family, pyrin containing 3 (NLRP3) inflammasome activation triggered by Aβ responsible for retinal pigment epithelium (RPE) dysfunction the onset of AMD; however, detailed molecular mechanism remains unclear. In this study, we investigated involvement NADPH oxidase‐ and mitochondria‐derived...
Photoreceptors, especially cones, which are enriched in the human macula, have high energy demands, making them vulnerable to metabolic stress. Metabolic dysfunction of photoreceptors and their supporting retinal pigment epithelium (RPE) is an important underlying cause degenerative diseases. However, how cones macula support exorbitant demand communicate with RPE unclear. By profiling metabolite uptake release analyzing genes, we found cone-rich retinas share specific features upregulated...
To compare functional and structural changes in the retina patients with aquaporin-4 immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica spectrum disorder (NMOSD) multiple sclerosis (MS).Cross-sectional study; biochemical study of human retinas.A total 181 participants, including 22 consecutive (44 eyes) NMOSD, 131 (262 (MS), 28 normal subjects (56 eyes). In addition, 8 eyeballs from healthy donors were used for analysis.Full-field electroretinography (ERG) spectral-domain OCT...
Escherichia coli contains a number of antitoxin-toxin modules on its chromosome, which are responsible for cell growth arrest and possible death. ChpBK is toxin encoded by the ChpBIK module. This module consists pair genes, chpBI chpBK encoding antitoxin ChpBI ChpBK, respectively. 116 amino acid residues, sequence shows 35% identity 52% similarity to MazF, another E. toxin. MazF has been shown be sequence-specific (ACA) endoribonuclease that cleaves cellular mRNAs effectively blocks protein...