A5043765077- Hematopoietic Stem Cell Transplantation
- Mesenchymal stem cell research
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Transplantation: Methods and Outcomes
- Lymphoma Diagnosis and Treatment
- RNA Interference and Gene Delivery
- T-cell and B-cell Immunology
- Bone and Joint Diseases
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cytomegalovirus and herpesvirus research
- Platelet Disorders and Treatments
- Neonatal Respiratory Health Research
- Blood groups and transfusion
- Virus-based gene therapy research
- Retinoids in leukemia and cellular processes
- Chronic Lymphocytic Leukemia Research
- Cancer, Hypoxia, and Metabolism
- Genetic Neurodegenerative Diseases
- Amyotrophic Lateral Sclerosis Research
- Neutropenia and Cancer Infections
- Immunodeficiency and Autoimmune Disorders
- Polyomavirus and related diseases
Air Force General Hospital PLA
2013-2025
Air Force Medical University
2025
People's Liberation Army Air Force
2011-2017
Chinese People's Liberation Army
2016
Chinese PLA General Hospital
2008
Shanghai Institute of Hematology
2001-2005
Academy of Military Medical Sciences
2001
Chinese Academy of Medical Sciences & Peking Union Medical College
2001
Mesenchymal stem cell (MSC)-based therapies exhibit beneficial effects on various forms of tissue damage, including ionizing radiation-induced lesions. However, whether radiation affects the functions human umbilical cord mesenchymal cells (hucMSCs) remains unclear. This study aimed to investigate effect and possible mechanisms proliferation differentiation hucMSCs. The hucMSCs were divided into 1 Gy group (exposure a single dose (1 Gy) X-ray Gy/min) for 14 days) control (without treatment)...
We report here the preliminary results of allogeneic hematopoietic stem cell transplantation with mesenchymal cells (MSCs) for 6 cases severe aplastic anemia. The patients ranged in age from 3 to 16 years, and median time diagnosis was 32 months (range: 3-156 months). conditioning regimens consisted fludarabine, cyclophosphamide, antithymocyte globulin or without busulfan. Graft-versus-host disease (GvHD) prevented by administration cyclosporine A, methotrexate, mycophenolate mofetil,...
Abstract Background Though accumulated evidence has demonstrated visceral organ involvement in acute graft-versus-host disease (aGVHD), how aGVHD influences the bone marrow (BM) niche and reconstitution of hematopoiesis post-hematopoietic stem cell transplantation remains largely unknown. Methods In current study, morphology, immunophenotype, multi-differentiation capacity, self-renewal promotion MSCs from non-aGVHD patients were investigated. Additionally, stemness hematopoiesis-promoting...
Haploidentical Hematopoietic stem cell transplantation (Haplo-HSCT) has provided an alternative option since virtually all patients have immediately available donor. Here, we report the results of Haplo-HSCT with granulocyte-colony-stimulating factor (G-CSF) mobilized bone marrow grafts plus peripheral blood cells as without T-cell depletion. Twenty-nine mean age 27.27 years (ranging from 15 to 51 years) were enrolled in this study, and 10 cases high risk status. The received myeloablative...
This study was aimed to investigate the effect of dendritic cell-derived exosome (DCex) on in vitro osteoblast differentiation human bone marrow mesenchymal stem cells (hBM-MSC). DCex were harvested from DC culture supernatants by ultracentrifugation. The morphology observed using transmission electron microscopy and surface marker expression detected flow cytometry. MSCs at passage 3 used this study. incorporation into under a confocal microscope. either exposed (10 µg/ml) or standard...
During human cytomegalovirus (CMV) infection after umbilical cord blood or HLA-matched hematopoietic stem cell transplantation (HSCT), a population of NKG2C-expressing natural killer (NK) cells expand and persist. The expanded NK express high levels inhibitory immunoglobulin-like receptors (KIR) specific for self-HLA potently produce IFNγ. However, it remains unknown whether similar events would occur haploidentical HSCT (haplo-HSCT). Here, we demonstrated that IFNγ-producing were in...
In this report, the authors describe a protocol for haploidentical bone marrow transplantation in children who received G-CSF-mobilized grafts without T-cell depletion from HLA-mismatched parents. Forty-two of 45 patients achieved complete donor hematopoietic engraftment; medium time neutrophil and platelet recovery was 17 19 days, respectively. Three died early transplantation-associated complications; other causes death included relapse (11 cases), fungal pneumonia (5), acute...
Abstract The clinical applications of human leukocyte antigen (HLA) haploidentical hematopoietic stem cells transplantation (haplo-HSCT) have offered most the young severe aplastic anemia (SAA) patients an opportunity to accept curative therapy at early stage bone marrow lesions. However, outcome juvenile SAA received haplo-HSCT remain be improved due high incidence graft failure and vs host disease (GVHD). Mesenchymal (MSCs) been characterized by their hematopoiesis-supporting...
Mesenchymal stem cells (MSCs) and their progenies are important supporting in the bone marrow (BM) microenvironment. However, function kinetics of MSCs post-hematopoietic cell transplant (HSCT) remain unknown. In present study, were cultured from a total 76 BM samples 15 patients receiving HSCT. Colony-forming unit fibroblasts before pre-conditioning 1, 3, 6 9 months post-HSCT counted to quantify MSCs. Hematopoiesis-supporting activity was observed with long-term culture hematopoietic...
In this study, 25 children with high-risk acute leukemia received haploidentical hematopoietic stem cell transplant (haplo-HSCT) co-transfusion of umbilical cord multipotent mesenchymal cells (UC-MSCs). Adverse effects, recovery, complications and outcome were observed during a median follow-up 12.8 months (range: 3–25 months). Myeloid engraftment was rapid, the time to neutrophil platelet recovery 15.12 days 20.08 days, respectively. Eight patients developed grade I skin graft-versus-host...
In order to study the neuroprotective mechanism of cinnamaldehyde on reserpine-induced Parkinson's disease(PD) rat models, 72 male Wistar rats were randomly divided into blank group, model Madopar and high-, medium-, low-dose groups. Except for other groups intraperitoneally injected with reserpine 0.1 mg·kg~(-1) once every morning, solutions gavaged afternoon. Open field test, rotarod oral chewing movement evaluation carried out in experiment. The brain was taken fixed. positive expression...
Here, we report the preliminary results of haploidentical hematopoietic stem cell transplantation (Haplo-HSCT) with granulocyte-colony-stimulating factor (G-CSF) mobilized bone marrow grafts without T-cell depletion for 10 patients refractory non-Hodgkin lymphoma accompanied by involvement. Eight received a conditioning regimen consisting high-doses cytarabine and cyclophosphamide total body irradiation, whereas two cases were preconditioned busulfan, thiotepa, cyclophosphamide. All had...
This study was purposed to investigate the effect of umbilical cord mesenchymal cells (UC-MSC) infusion on pulmonary infection in haploidentical hematopoietic stem cell transplantation (hi-HSCT). The 83 patients underwent hi-HSCT detected and analysed, among them 42 received hi-HSCT, 41 combined with UC-MSC infusion. results showed that 31 cases (73.81% ± 6.78%) were infected by cytomegalovirus 21 experienced infections, including infections fungal, virus, bacteria, tubercle bacillus, PCP so...
Abstract We reported a novel function of recombinant human thrombopoietin (TPO) in increasing hematopoietic stem and progenitor cell (HSPC) homing to the bone marrow (BM). Single doses TPO treatment recipients immediately after BM transplantation showed significantly improved HSPCs BM, which subsequently resulted enhanced short- long-term engraftment mice. found that could downregulate expression secretion matrix metalloproteinase 9 cells. As result, SDF-1α level was increased niche....