A5100680484- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Photoreceptor and optogenetics research
- Diet and metabolism studies
- Retinal and Macular Surgery
- Glaucoma and retinal disorders
- Ocular Disorders and Treatments
- Corneal Surgery and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Neuroscience and Neuropharmacology Research
- Biochemical effects in animals
- Neuroscience and Neural Engineering
- Drug-Induced Ocular Toxicity
- Advanced Vision and Imaging
- Advanced Optical Sensing Technologies
- Ocular Surface and Contact Lens
- Optical Coherence Tomography Applications
- Ferroptosis and cancer prognosis
- Optical measurement and interference techniques
- Mitochondrial Function and Pathology
- Medical Image Segmentation Techniques
- Adipose Tissue and Metabolism
- Neurological Disease Mechanisms and Treatments
Fujian Medical University
2024-2025
First Affiliated Hospital of Xiamen University
2024-2025
Henan Agricultural University
2024-2025
Southwest Medical University
2025
University of Wisconsin–Madison
2024
Xiamen University
2021-2024
ShanghaiTech University
2018-2024
China Railway Group (China)
2024
Chongqing Medical University
2019-2024
Ningxia Medical University
2024
The full-field electroretinogram (ERG) is a mass electrophysiological response to diffuse flashes of light and used widely assess generalized retinal function. This document, from the International Society for Clinical Electrophysiology Vision (ISCEV), presents an updated revised ISCEV Standard clinical ERG testing. Minimum protocols basic stimuli, recording methods reporting are specified, promote consistency diagnosis, monitoring inter-laboratory comparisons, while also responding evolving...
Clinical electrophysiological testing of the visual system incorporates a range noninvasive tests and provides an objective indication function relating to different locations cell types within system. This document developed by International Society for Electrophysiology Vision introduction standard electrodiagnostic procedures in widespread use including full-field electroretinogram (ERG), pattern (pattern ERG or PERG), multifocal (multifocal mfERG), electrooculogram (EOG) cortical-derived...
Abstract The multifocal electroretinogram (mfERG) is an electrophysiological test that allows the function of multiple discrete areas retina to be tested simultaneously. This document, from International Society for Clinical Electrophysiology Vision (ISCEV), presents updated and revised ISCEV standard clinical mfERG defines minimum protocols basic recording reporting so responses can recognized compared different laboratories worldwide. major changes with previous relate length m-sequences...
The treatment options for diabetic retinopathy (DR) are limited. Mesenchymal stem cells (MSCs) a promising option diabetes and its complications. In this pilot clinical trial, we evaluated the safety efficacy of intravenous autologous bone marrow MSCs (ABMSC) DR.In total, 34 eyes with non-proliferative or proliferative DR (NPDR, n = 19; PDR, 15) from 17 patients were analyzed. Treatment involved one infusion 3 × 106/kg ABSMCs. patients' vital signs monitored, along immune allergic reactions....
Abstract Objectives To evaluate the long‐term biosafety and efficacy of transplantation human embryonic stem cells‐derived retinal pigment epithelial (hESC‐RPE) cells in early‐stage Stargardt macular degeneration (STGD1). Materials methods Seven patients participated this prospective clinical study, where they underwent a single subretinal 1 × 10 5 hESC‐RPE one eye, whereas fellow eye served as control. These were reassessed for 60‐month follow‐up through systemic ophthalmic examinations....
We report a case of 34-year-old lady with multiple joint pain. Autoimmune diseases were considered first positive result anti-Ro antibody and her right knee cavity effusion. Later, bilateral interstitial changes in lungs mediastinal lymphadenopathy found after chest CT scanning. Empirical quinolone therapy was given although pathological examinations blood, sputum bronchoalveolar lavage fluid (BALF) did not find anything. Finally, Legionella pneumophila identified by target next-generation...
Traditional villages are human treasures left behind by the integration of material space and non-material culture in process agricultural civilization. Studying spatial autocorrelation characteristics, heterogeneity, quantitative attribution factors influencing traditional provides new ideas for protection villages. This study took 75 as research object. From perspective used nuclear density estimation Moran’s I index to analyze distribution patterns selected 12 construct GWR modeling...
Optical coherence tomography angiography (OCTA) is a noninvasive imaging technique that can reveal high-resolution retinal vessels. In this work, we propose an accurate and efficient neural network for vessel segmentation in OCTA images. The proposed achieves accuracy comparable to other SOTA methods, while having fewer parameters faster inference speed (e.g. 110x lighter 1.3x than U-Net), which very friendly industrial applications. This achieved by applying the modified Recurrent ConvNeXt...
Medical artificial intelligence (AI) has been moving from the research phase to clinical implementation. However, most AI-based models are mainly built using high-quality images preprocessed in laboratory, which is not representative of real-world settings. This dataset bias proves a major driver AI system dysfunction. Inspired by design flow cytometry, DeepFundus, deep-learning-based fundus image classifier, developed provide automated and multidimensional sorting address this data quality...
In our retrospective cohort study, we aim to explore whether Azvudine modifies the risk of death in COVID-19 patients. It was conducted on medical records patients, consecutively admitted for pneumonia two hospitals Chongqing, China. Based treatment exposure, patients were divided into group and non-Azvudine group. We used 1:2 ratio propensity score matching (PSM) study adjust confounding factors differences between groups. There 1072 included original cohort. With PSM, 195 390 The results...
Abstract Glial dysfunction is found in a number of retinal vascular diseases but its link with blood‐retinal barrier (BRB) breakdown remains poorly understood. The present study tested the hypothesis that glial major contributor to BRB hallmark diseases. We investigated thespecificity purportedly selective toxin, DL‐α‐aminoadipic acid (DL‐α‐AAA) on different types ocular cells vitro and then effect disruption vasculature after intraocular injection DL‐α‐AAA or siRNA targeting glutamine...
Clustering is one of the most popular methods for data analysis, which prevalent in many disciplines such as image segmentation, bioinformatics, pattern recognition and statistics etc. The simplest clustering algorithm K-means because its easy implementation, simplicity, efficiency empirical success. However, real-world applications produce huge volumes data, thus, how to efficiently handle these an important mining task has been a challenging significant issue. In addition, MPI (Message...
Retinitis pigmentosa (RP) is a hereditary retinal degeneration disease with no effective therapeutic approaches. Inflammatory and immune disorders are thought to play an important role in the pathogenesis of RP. Human umbilical cord mesenchymal stem cells (UCMSCs), multiple biological functions such as anti-inflammation immunoregulation, have been applied different systemic diseases. We conducted phase I/II clinical trial aiming evaluate safety efficacy intravenous administration UCMSCs...
Macular degeneration is a leading cause of irreversible vision loss, significantly impacting quality life. To enhance clinical practice and reduce the risk drug-related macular degeneration, we analyzed trends using real-world data. Disproportionality analysis adverse event reports from FDA Adverse Event Reporting System (FAERS, 2004–2023) identified 67,683 cases involving 1402 drugs. Among these, 42 drugs were linked to significant risks, including treatments for breast cancer (tamoxifen,...
The benefits of partially substituting inorganic fertilizers with organic have been extensively acknowledged. However, the key mechanisms behind nutrient transformation and supply for stable crop yields are still not fully understood. Based on an 11-year field experiment a wheat–maize rotation system, this study explored advantages combined straw manure substitution under various regimes. These regimes included unfertilized control (CK), nitrogen, phosphorus, potassium (NPK), NPK substituted...
Abstract Background Age-dependent accumulation of lipofuscin in the retinal pigment epithelium (RPE) is closely related to etiology autosomal recessive Stargardt’s disease (STGD1) and dry age-related macular degeneration (AMD). N -retinylidene- -retinylethanolamine (A2E) a leading component RPE that highly susceptible blue light. Ferroptosis an iron-dependent form non-apoptotic cell death characterized by lipid peroxides lethal level, which plays important role diseases. However, it remains...
Purpose This study aims to investigate the effects and mechanism of action metformin on retinal neovascularization fibrosis in a mouse model neovascular age-related macular degeneration (nAMD). Methods Very low-density lipoprotein receptor knockout ( Vldlr −/− ) mice, nAMD, were used this study. mice administered postnatal day (P) 20 for days (early stage pathological change) or at 5.5 months age 45 (late change). Retinal leakage was examined by fundus fluorescein angiography (FFA). assessed...
Abstract Ferroptosis, a form of iron‐dependent cell death, plays pivotal role in age‐related diseases; yet, its impact on cellular senescence and healthspan mammals remains largely unexplored. This study identifies ferroptosis as key regulator senescence, showing that inhibition can significantly delay aging extend across multiple species. During is progressively exacerbated, marked by increased lipid peroxidation, oxidative stress, diminished glutathione peroxidase 4 (GPX4) levels....
Retinal amyloid angiopathy (RAA) is an ocular manifestation of hereditary transthyretin (hATTR). We aimed to investigate the characteristics disease progression RAA in patients with ATTR Gly83Arg amyloidosis and evaluate effect on vision. observed clinical records 131 individuals from a seven-generation Chinese family. In this family, 18 symptomatic were our followers. And follow-up was 61.6 ± 47.5 months (range, 1-164; median, 48 months). diagnosed after vitrectomies based fundus...
Clustering is one of the most popular methods for exploratory data analysis, which prevalent in many disciplines such as image segmentation, bioinformatics, pattern recognition and statistics etc. The famous clustering algorithm K-means because its easy implementation, simplicity, efficiency empirical success. However, real-world applications produce huge volumes data, thus, how to efficiently handle these an important mining task has been a challenging significant issue. In addition, MPI...
Mammalian Müller glia (MG) possess limited regenerative capacities. However, the intrinsic capacity of mammalian MG to transdifferentiate generate mature neurons without transgenic manipulations remains speculative. Here we show that MAP4K4, MAP4K6 and MAP4K7, which are conserved Misshapen subfamily ste20 kinases homologs, repress YAP activity in therefore restrict their ability be reprogrammed. by treating with a small molecule inhibitor MAP4K4/6/7, mouse regain proliferate enter into...