A5100701680- Connexins and lens biology
- Heat shock proteins research
- Yersinia bacterium, plague, ectoparasites research
- Endoplasmic Reticulum Stress and Disease
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Advanced Glycation End Products research
- Cholesterol and Lipid Metabolism
- RNA regulation and disease
- Retinal Diseases and Treatments
- Cancer, Lipids, and Metabolism
- RNA Interference and Gene Delivery
- Air Quality and Health Impacts
- Mitochondrial Function and Pathology
- Ion channel regulation and function
- Computational Drug Discovery Methods
- Retinal Development and Disorders
- Protein Structure and Dynamics
- ATP Synthase and ATPases Research
- Biochemical effects in animals
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Power Systems and Renewable Energy
- Autophagy in Disease and Therapy
- Bacterial biofilms and quorum sensing
Second Affiliated Hospital of Zhejiang University
2018-2025
Zhejiang University
2018-2025
Fudan University
2014-2025
Huashan Hospital
2014-2025
Xizang Minzu University
2024
Southeast University
2024
Henan Polytechnic University
2024
Hunan University of Traditional Chinese Medicine
2024
Children's Hospital of Zhejiang University
2024
Affiliated Hospital of Hangzhou Normal University
2020-2024
The aim of this study was to compare transplanted mesenchymal stem cells (MSCs) with nucleus pulposus (NPCs) in a degenerative disc model rabbits determine the better candidate for cell therapy.Mesenchymal and NPCs were rabbit degeneration. Changes height, according plain radiography, T2-weighted signal intensity on MR imaging, histology, sulfated glycosaminoglycan (sGAG)/DNA, associated gene expression levels, evaluated among healthy controls without surgery, sham-operated animals which...
Recent experiments suggested that ATP can effectively stabilize protein structure and inhibit aggregation when its concentration is less than 10 mM, which significantly lower cosolvent concentrations required in conventional mechanisms. The ultrahigh efficiency of suggests a unique mechanism fundamentally different from previous models cosolvents. In this work, we used molecular dynamics simulation to study the interactions ATPs with three proteins: lysozyme, ubiquitin, malate dehydrogenase....
Bacterial biofilm is the complicated clinical issues, which usually results in bacterial resistance and reduce therapeutic efficacy of antibiotics. Although micelles have been drawn attention treatment biofilms, effectively permeate retain biofilms still facing a big challenge. In this study, we fabricated on-demand pH-sensitive surface charge-switchable azithromycin (AZM)-encapsulated (denoted as AZM-SCSMs), aiming to act agent for treating Pseudomonas aeruginosa (P. aeruginosa) biofilms....
Aims Previous studies have suggested an association between retinal artery occlusion (RAO) and ischaemic stroke (IS), both associated with elevated inflammatory factors. However, the role of high-sensitivity C-reactive protein (hs-CRP) in sequential onset these two diseases is still unclear. Based on this evidence, we evaluated hs-CRP RAO IS. Methods We examined from large multicentre cohort study UK Biobank Chinese Retinal Artery Occlusion study. Cox proportional hazard models were used to...
Abstract Endometrial cancer (EC) is a significant health threat to women, with recurrence after treatment posing major challenge. While abnormal cholesterol metabolism has been implicated in EC progression, the underlying mechanisms remain unclear. In this study, we identified lanosterol synthase (LSS) as key mediator associated EC. We found that LSS significantly upregulated tissues. Functional assays revealed promotes cell proliferation and migration, inhibits apoptosis, drives tumor...
Abstract Alzheimer’s disease is the most common cause of dementia. Although increasing evidence suggests that disruptions in lipid metabolism are closely associated with disease, overall profile and sterol changes occur brain during remains unclear. In this study, we compared tissues extracted from 32-week-old male wild-type mice 5×FAD transgenic model mice, which carry mutations amyloid precursor protein ( APP ) presenilin 1 PS1 genes. Using untargeted lipidomics sterolomics techniques,...
This article combines physical experiments and molecular simulations to explore the influence of added water on CH 4 adsorption in different metamorphism grade coal. Specifically, under pressures, when content increases from 0% 6.26%, amount high metamorphic coal decreases by approximately 76.72%, 63.82%, 59.53%, 56.10%, 50.94%. However, decrease gas fat long flame is lower than that anthracite, indicating effect adding most significant coal, while medium low relatively small. The average...
In this study, a universal protein expression enhancement RNA tool, termed RNAe, was developed by modifying recently discovered natural long non-coding RNA. At the moment, RNAe is only technology for gene enhancement, as opposed to silencing, at post-transcriptional level. With technology, an of 50–1000% achievable, with more than 200% achieved in most cases. This work identified sufficient and necessary element function, which found be merely 300 nucleotides named minRNAe. It contains 72-nt...
In the complex panorama of autoimmune diseases, characterisation pivotal contributing autoantibodies that are involved in disease progression remains challenging. This study aimed to employ a global antibody profiling strategy identify novel antibodies and investigate their association with systemic sclerosis (SSc).