A5050248453- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Corneal Surgery and Treatments
- Retinal and Macular Surgery
- Retinopathy of Prematurity Studies
- Neurosurgical Procedures and Complications
- Mitochondrial Function and Pathology
- Cerebral Venous Sinus Thrombosis
- Parasitic Infections and Diagnostics
- Neuroscience and Neural Engineering
- Neuroinflammation and Neurodegeneration Mechanisms
- Toxoplasma gondii Research Studies
- Genetic and rare skin diseases.
- Autoimmune and Inflammatory Disorders
- Neuroscience and Neuropharmacology Research
- Cytomegalovirus and herpesvirus research
- Mesenchymal stem cell research
- Intraocular Surgery and Lenses
- Photoreceptor and optogenetics research
- Ocular Diseases and Behçet’s Syndrome
- Histiocytic Disorders and Treatments
- Retinal Imaging and Analysis
Southwest Hospital
2009-2023
Army Medical University
2009-2023
ORCID
2021
The treatment options for diabetic retinopathy (DR) are limited. Mesenchymal stem cells (MSCs) a promising option diabetes and its complications. In this pilot clinical trial, we evaluated the safety efficacy of intravenous autologous bone marrow MSCs (ABMSC) DR.In total, 34 eyes with non-proliferative or proliferative DR (NPDR, n = 19; PDR, 15) from 17 patients were analyzed. Treatment involved one infusion 3 × 106/kg ABSMCs. patients' vital signs monitored, along immune allergic reactions....
Abstract Objectives To evaluate the long‐term biosafety and efficacy of transplantation human embryonic stem cells‐derived retinal pigment epithelial (hESC‐RPE) cells in early‐stage Stargardt macular degeneration (STGD1). Materials methods Seven patients participated this prospective clinical study, where they underwent a single subretinal 1 × 10 5 hESC‐RPE one eye, whereas fellow eye served as control. These were reassessed for 60‐month follow‐up through systemic ophthalmic examinations....
Retinitis pigmentosa (RP) is a hereditary retinal degeneration disease with no effective therapeutic approaches. Inflammatory and immune disorders are thought to play an important role in the pathogenesis of RP. Human umbilical cord mesenchymal stem cells (UCMSCs), multiple biological functions such as anti-inflammation immunoregulation, have been applied different systemic diseases. We conducted phase I/II clinical trial aiming evaluate safety efficacy intravenous administration UCMSCs...
In several vertebrate classes, the Müller glia are capable of de-differentiating, proliferating, and acquiring a progenitor-like state in response to acute retinal injury or exogenous growth factors. Our previous study has shown that cells can be activated de-differentiated into progenitors during Royal College Surgeons (RCS) rats' degeneration, although limited proliferation cannot maintain function. We now report rat stem (rSCs) transplanted RCS rats slowed progression morphological...
Cerebral venous sinus thrombosis or stenosis (here collectively referred to as cerebral occlusion, CVSO) can cause chronically-elevated intracranial pressure (ICP). Patients may have no neurological symptoms other than visual impairment, secondary bilateral papilledema. Correctly recognizing these conditions, through proper ophthalmological examination and brain imaging, is very important avoid delayed diagnosis treatment. We report a case series of 3 patients with chronic CVSO, who were...
To compare changes of chorioretinal blood perfusion between Bietti crystalline dystrophy (BCD) and typical retinitis pigmentosa perform a staging longitudinal analysis in BCD.Twenty-eight patients with BCD (56 eyes), 28 healthy subjects eyes) were enrolled. Macular structural parameters subfoveal choroidal thickness measured using optical coherence tomography. Retinal vessel densities calculated tomography angiography. Choroidal was assessed through indocyanine green The results the group...
Retinitis pigmentosa (RP) is a hereditary retinal degenerative disease leading to eventual blindness. When RP combined with macular edema (ME), the visual impairment further worsens. We compared modified sub-Tenon's capsule injection of triamcinolone acetonide (TA) and intravenous infusion umbilical cord mesenchymal stem cells (UCMSCs) in treatment ME (RP-ME) assess their safety efficacy eliminating restoring function. A phase I/II clinical trial enrolled 20 patients was conducted. All were...
To investigate the predisposing clinical parameters and characteristics of fundus imaging patients with persistent subretinal fluid (PSF) after successful repair rhegmatogenous retinal detachment.A retrospective study recruiting 57 was conducted. All underwent pars plana vitrectomy silicone oil tamponade. Patients were divided into two groups: presenting PSF by time removal as group no control group. followed up for 3 months or longer primary surgery. Ophthalmic examinations, including...
Huang, Xiao Yong Dr.; Zhao, Tongtao Bachelor, Xi Yu; Berrocal, Audina M. John, Vishak Dr.Editor(s): McDonald, H. Richard Author Information
Abstract Background: Retinitis pigmentosa (RP) is a hereditary retinal degenerative disease leading to eventual blindness. Macular edema (ME) frequent complication in RP. When RP combined with ME, the visual impairment further worsens. Well controlled ME crucial prevent from advancing. We compared intravenous infusion of umbilical cord mesenchymal stem cells (UCMSCs) and modified sub-Tenon’s capsule injection triamcinolone acetonide (TA) treatment assess their safety efficacy eliminating...