A5100707991- Thyroid Disorders and Treatments
- Neonatal Health and Biochemistry
- Growth Hormone and Insulin-like Growth Factors
- Neuroscience of respiration and sleep
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Acne and Rosacea Treatments and Effects
- Ion Transport and Channel Regulation
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebral Venous Sinus Thrombosis
- Intracranial Aneurysms: Treatment and Complications
- Dermatology and Skin Diseases
- Hormonal Regulation and Hypertension
- Hypothalamic control of reproductive hormones
- Neurosurgical Procedures and Complications
- Hemoglobinopathies and Related Disorders
- Autophagy in Disease and Therapy
- Heavy Metal Exposure and Toxicity
- Thyroid Cancer Diagnosis and Treatment
- Optical Polarization and Ellipsometry
- Sphingolipid Metabolism and Signaling
- Neurological diseases and metabolism
- Fetal and Pediatric Neurological Disorders
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
China National Nuclear Corporation
2020
Chengdu Medical College
2020
China Medical University
2008-2018
Army Medical University
2018
Southwest Hospital
2018
Tianjin Medical University General Hospital
2015-2018
First Hospital of China Medical University
2013-2017
Bloodworks Northwest
2013
The University of Texas Southwestern Medical Center
2010
Antibiotic resistance is a recognized and concerning public health issue. Gram-negative bacilli, such as Pseudomonas aeruginosa (P. aeruginosa), are notorious for their rapid development of drug resistance, leading to treatment failures. TanReQing injection (TRQ) was chosen explore its pharmacological mechanisms against clinical multidrug-resistant P. (MDR-PA), given antibacterial anti-inflammatory properties. We revealed the expression proteins genes in after co-culture with TRQ. This study...
Developmental iodine deficiency results in inadequate thyroid hormone (TH), which damages the hippocampus. Here, we explored roles of hippocampal doublecortin and neural cell adhesion molecule (NCAM)-180 developmental hypothyroidism.Two rat models were established with either an iodine-deficient diet, or propylthiouracil (PTU)-adulterated water (5 ppm 15 ppm) to impair function, pregnant rats from gestational day 6 until postnatal (PN) 28. Silver-stained neurons protein levels NCAM-180...
One hundred and four workers ingested excessive levels of arsenic in an accident caused by leakage pipeline a copper-smelting factory. Clinical examinations were performed physicians local hospital. Excreted urinary species determined cold trap hydride generation atomic absorption spectrometry. In the initial toxic phase, gastrointestinal symptoms predominant (83 people, 79.8%). Most patients showed leucopenia (72 69.2%), increased serum alanine aminotransferase (84 80.8%) aspartate (58...
Abstract Background Skin 16S microbiome diversity analysis indicates that the Staphylococcus genus, especially aureus ( S. ), plays a crucial role in inflammatory lesions of acne. However, current animal models for acne do not fully replicate human diseases, pustular acne, which limits development anti‐acne medications. Aims The aim is to develop mouse model establishing an more closely mimics clinical presentation This will provide new research platform screening drugs and evaluating...
The testicular hormone Insl3 is critical for mouse gubernacular development. Knockout mice exhibit bilateral intra-abdominal cryptorchidism with absent gubernaculum. Prior studies described torsion of the vas deferens in mutant mice. We performed a detailed anatomical analysis and testis to characterize associated anomalies further.Insl3 wild-type (Insl3(+/+)), heterozygous (Insl3(+/-)) knockout (Insl3(-/-)) male were examined either prepubertally (postnatal day 23) or adulthood 90 later)....
Iodine is essential for the synthesis of thyroid hormone. deficiency (ID)-induced hypothyroxinaemia and hypothyroidism during developmental period contribute to impairments function in brain, such as psychomotor motor alterations. However, mechanisms are still unclear. Therefore, present research study effects caused by mild ID severe or methimazole (MMZ) on dendritic growth filial cerebellar Purkinje cells (PCs) underlying mechanisms.A maternal model was established Wistar rats using a...
Abstract Acne vulgaris is a disorder of the pilosebaceous unit that primarily caused by hyperseborrhoea, colonization with Propionibacterium acnes , hyperkeratosis and an inflammatory response. Existing pharmacodynamic assessment methods focus on single causative factor at certain time point, making it difficult to assess multiple factors simultaneously in real time. Therefore, crucial establish dynamic nondestructive method for acne vivo. This study utilized four‐dimensional optical imaging...
Abstract Background Developmental iodine deficiency (ID) leads to inadequate thyroid hormone that impairs learning and memory with an unclear mechanism. Here, we show hippocampal extracellular signal-regulated kinase (ERK1/2) cAMP response element-binding protein (CREB) are implicated in the impaired lactational adolescent rat hippocampus following developmental ID hypothyroidism. Methods Three models were created by administrating dam rats either iodine-deficient diet or propylthiouracil...
Abstract Developmental iodine deficiency (ID) leads to inadequate thyroid hormone that impairs learning and memory with an unclear mechanism. Here, we show hippocampal neurogranin, calcium/calmodulin dependent protein kinase II (CaMKII), calmodulin (CaM) calcineurin (CaN) are implicated in the brain impairment lactational rat hippocampus following developmental ID hypothyroidism. Three models were created by administrating dam rats either iodine‐deficient diet or propylthiouracil (PTU, 5 ppm...
Parkinson's disease (PD) is one of the most common neurodegenerative diseases worldwide. Although dopamine replacement therapy mitigates motor dysfunction in PD patients, there are no therapeutics that currently available to reverse neuronal cell death substantia nigra pars compacta (SNc), which main region for loss patients. The protein concentration Pilose antler extracts (PAEs) was estimated using Bradford Protein Assay Kit. Hematoxylin and eosin (HE) staining used evaluate protective...
ABSTRACT Hypothyroxinemia induced by maternal mild iodine deficiency causes neurological deficits and impairments of brain function in offspring. is prevalent developing developed countries alike. However, the mechanism underlying these remains less well known. Given that myelin plays an important role learning memory function, we hypothesize hippocampal myelinated growth may be impaired rat offspring exposed to hypothyroxinemia deficiency. To test this hypothesis, female Wistar rats were...
Cerebral venous sinus thrombosis or stenosis (here collectively referred to as cerebral occlusion, CVSO) can cause chronically-elevated intracranial pressure (ICP). Patients may have no neurological symptoms other than visual impairment, secondary bilateral papilledema. Correctly recognizing these conditions, through proper ophthalmological examination and brain imaging, is very important avoid delayed diagnosis treatment. We report a case series of 3 patients with chronic CVSO, who were...
Developmental iodine deficiency (ID) leads to inadequate thyroid hormone that impairs the development of central nervous system with an unclear mechanism. Here, we show hippocampal apoptosis, synaptotagmin-1, and PSD-95 are involved in synaptic impairment following developmental ID.Two rat models were created by administrating dam rats either iodine-deficient diet or propylthiouracil (PTU, 15 ppm)-added drinking water from gestational day 6 till postnatal (PND) 28. Then, apoptosis...
We evaluated the role of p35 in maturation hippocampal granule neurons offspring caused by developmental iodine deficiency. Two rat models were established with either an iodine-deficient diet, or propylthiouracil-adulterated water (5 ppm) to impair thyroid function, pregnant rats from gestational day 6 until postnatal 28. The protein levels p35, cyclin-dependent kinase 5, β-catenin, and N-cadherin assessed on 14, 21, Dendritic morphogenesis newborn dentate gyrus was examined. Developmental...