A5083636779- Bacterial biofilms and quorum sensing
- Antimicrobial Resistance in Staphylococcus
- Microbial Metabolism and Applications
- Antibiotic Resistance in Bacteria
- Streptococcal Infections and Treatments
- Probiotics and Fermented Foods
- Plant-based Medicinal Research
- Vibrio bacteria research studies
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Antibiotic resistance is a recognized and concerning public health issue. Gram-negative bacilli, such as Pseudomonas aeruginosa (P. aeruginosa), are notorious for their rapid development of drug resistance, leading to treatment failures. TanReQing injection (TRQ) was chosen explore its pharmacological mechanisms against clinical multidrug-resistant P. (MDR-PA), given antibacterial anti-inflammatory properties. We revealed the expression proteins genes in after co-culture with TRQ. This study...
The rise of antibiotic resistance and dearth novel antibiotics have posed a serious health crisis worldwide. In this study, we screened combination nonantibiotics providing viable strategy to solve issue by broadening the antimicrobial spectrum. We found that chenodeoxycholic acid (CDCA), cholic derivative traditional Chinese medicine (TCM) Tanreqing (TRQ), synergizes with amikacin against Staphylococcus aureus in vitro, synergistic killing was effective diverse methicillin-resistant S....
Pseudomonas aeruginosa is an opportunistic pathogen that can infect a wide variety of hosts including humans, plants, and animals. The production virulence factors the determinant infection paradigm under orchestrated regulation via cell-to-cell communication process called quorum sensing (QS). To disable QS circuits prevent bacterial infections, large battery anti-QS agents, particularly from traditional Chinese medicine have been developed. Here, we used P. as model microorganism to...
Staphylococcus aureus has been recognized as an important human pathogen and poses a serious health threat worldwide. With the advent of antibiotic resistance, such increased number methicillin-resistant (MRSA), there is urgent need to develop new therapeutical agents. In this study, Chinese traditional medicine Tanreqing (TRQ) used alternative treating agent against MRSA we aim unravel mode action TRQ underlying inhibition. treatment affected numerous gene expression revealed by RNA-seq...
Methicillin-resistant Staphylococcus aureus (MRSA) has posed a severe global health threat. In this study, we screened an antibiotic and non-antibiotic combination that provides viable strategy to solve issue by broadening the antimicrobial spectrum. We found chenodeoxycholic acid (CDCA) could synergistically act with carbapenem antibiotics eradicate MRSA-related infections. This synergy specifically targets MRSA was also validated using 25 clinical strains time-kill analysis. speculated...