A5087970596- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Dysphagia Assessment and Management
- Liver Disease Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Gastrointestinal motility and disorders
- Liver Disease and Transplantation
- Respiratory and Cough-Related Research
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Tracheal and airway disorders
- Inflammatory Bowel Disease
- Gut microbiota and health
- Microscopic Colitis
- Ion Channels and Receptors
- Biosimilars and Bioanalytical Methods
- Voice and Speech Disorders
- Potassium and Related Disorders
- Sleep and related disorders
- Obstructive Sleep Apnea Research
- Enhanced Recovery After Surgery
- Cardiovascular Function and Risk Factors
- Myofascial pain diagnosis and treatment
Tzu Chi University
2017-2025
Tzu Chi Foundation
2018-2024
Buddhist Tzu Chi Medical Foundation
2018-2023
Hualien Tzu Chi Medical Center
2022
Mackay Memorial Hospital
2015-2017
Buddhist Tzu Chi General Hospital
2017
Summary Background The pathogenesis of gastro‐oesophageal reflux disease (GERD) is complex and multifactorial. oesophageal hypervigilance anxiety scale (EHAS) a novel cognitive‐affective evaluation visceral sensitivity. Aims To investigate the interrelationship between EHAS symptom severity, psychological stress, acid burden, phenotypes, mucosal integrity in patients with GERD. Methods Patients chronic symptoms negative endoscopy underwent 24‐hour impedance‐pH monitoring for phenotyping,...
INTRODUCTION: Laryngopharyngeal reflux (LPR) is a clinical conundrum without diagnostic gold standard. The Esophageal Hypervigilance and Anxiety Scale (EHAS) questionnaire designed for cognitive-affective evaluation of visceral sensitivity. We hypothesized that esophageal hypervigilance symptom-specific anxiety have an etiopathological role in generation LPR symptoms, especially when gastroesophageal disease (GERD) cannot explain these symptoms. METHODS: Consecutive patients with and/or GERD...
Abstract Background This nationwide prospective registry study investigated the real-world effectiveness, safety, and persistence of vedolizumab (VDZ) in inflammatory bowel disease (IBD) patients Taiwan. Disease relapse rates after VDZ discontinuation due to reimbursement restriction were assessed. Methods Data collected prospectively (January 2018 May 2020) from Taiwan Society IBD registry. Results Overall, 274 (147 ulcerative colitis [UC] patients, 127 Crohn’s [CD] patients) included....
Discerning whether laryngeal symptoms result from gastroesophageal reflux is clinically challenging and a reliable tool to stratify patients needed. We aimed develop validate model predict the likelihood of disease (GERD) among with chronic symptoms.
We explored if a score derived from parameters esophageal testing could increase confidence in diagnosing conclusive gastroesophageal reflux disease and predicting outcome.
<b><i>Background/Aims:</i></b> We aimed to investigate gastrointestinal symptoms, clinical characteristics, and psychological factors in subjects with without sleep disturbance (SD) a health screening cohort. <b><i>Methods:</i></b> enrolled 2,752 consecutive during their checkups. All participants underwent an evaluation questionnaires. Demographic characteristics biochemical data were recorded. SD was confirmed when Pittsburgh Sleep Quality...
Abstract Background and Aim Laryngopharyngeal reflux (LPR) defined as of gastric content reaching above the upper esophageal sphincter is frequently found in patients with gastroesophageal disease (GERD). This study aimed to investigate clinical psychological differences between GERD or without LPR symptoms. Methods enrolled 303 consecutive proton pump inhibitor treatment‐naïve scheduled for endoscopy because troublesome symptoms recognized by non‐dyspepsia questionnaire score. Included were...
Among patients with chronic laryngeal symptoms, ambulatory reflux monitoring off acid suppression is recommended to evaluate for laryngopharyngeal (LPR). However, systems are diverse in configuration and capabilities, which present a challenge creating diagnostic reference standard these patients. This study aimed compare yield performance between symptoms.
Background: Visual analog scales (VAS) are simple, easy for patients to comprehend, and require limited translation. We evaluated the value of esophageal global symptom severity (GSS) measured using VAS in assessing initial reflux burden as compared other validated questionnaires, burden, outcome following management. Methods: analyzed pooled data from published historical cohorts undergoing pH-impedance testing symptoms three continents (North America, Europe, Asia). Univariate (Spearman...
ABSTRACT Background and Aim With rising rates of esophageal adenocarcinoma (EAC) in Western countries, Barrett's esophagus (BE) has become a growing concern. The increasing prevalence chronic gastroesophageal reflux disease (GERD) Taiwan suggests potential rise BE cases as well. A 2007 large‐scale study reported 1.06% Taiwan. Our multicenter prospective aims to evaluate the current identify key risk factors this region. Method We assessed outpatients undergoing upper gastrointestinal...
ABSTRACT Background Managing esophageal symptoms with normal acid exposure is challenging, requiring focus on both physiological and psychological factors. However, no studies have explored how patients perceive symptom changes after using alginates or proton‐pump inhibitors (PPIs) in this context. This study examines the interrelationships among reflux severity, hypervigilance, distress treated either alginate suspension PPIs. Methods We conducted a 2‐year prospective, randomized,...
Abstract Background/Aim Reflux episodes and postreflux swallow‐induced peristaltic wave (PSPW) index are useful impedance parameters that can augment the diagnosis of gastroesophageal reflux disease (GERD). However, manual analysis pH‐impedance tracings is time consuming, resulting in limited use these novel metrics. This study aims to evaluate whether a supervised learning artificial intelligence (AI) model identify PSPW index. Methods Consecutive patients underwent 24‐h impedance‐pH...
Patients with gastroesophageal reflux disease (GERD) frequently report symptoms like dyspepsia or/and irritable bowel syndrome (IBS). The aim of the study was to investigate impact symptom overlap on GERD burden. We also whether overlapping IBS would have different clinical and psychological features as compared alone.A total 2752 subjects were screened from a health check-up population. factors among alone two or all three diseases. All participants underwent an evaluation questionnaires...
Recurrence of gastroesophageal reflux disease (GERD) is common among patients who are no longer receiving proton pump inhibitors (PPIs). This study investigated factors associated with GERD recurrence.We included 499 consecutive completed validated and psychological questionnaires before undergoing upper endoscopy. All were treated PPIs followed up.Recurrence was observed in 89 (30.4%) 293 during the 1-year follow up. Patients recurrence had a higher prevalence diabetes mellitus (p = 0.037),...
The genotypes of hepatitis C virus (HCV) are associated with the therapeutic response. racial diversity Taitung, Taiwan is heterogeneous and a distinguishing feature; how such differences influence genotype distribution treatment outcome has not been well studied. objective this study to elucidate HCV in southeastern analyze influencing clinical implications. In retrospective cohort study, we included 343 patients who had treated peginterferon-alpha plus ribavirin. predominant area was type...
Abstract Background/Aim The aim was to investigate whether there is a difference in secondary peristalsis on high‐resolution manometry (HRM) among gastroesophageal reflux disease (GERD) patients with and without ineffective esophageal motility (IEM), healthy individuals. Methods Twenty‐eight GERD seventeen controls were included. Secondary stimulated by rapid injection of 20 ml air mid‐esophagus. We compared HRM metrics the response effective rate triggering between IEM controls. Results...
Straight leg raise (SLR) can be utilized to evaluate the integrity of esophagogastric junction during high-resolution manometry (HRM). We aim assess value transient hiatal separation SLR in symptomatic reflux patients.Consecutive patients undergoing esophageal HRM and pH monitoring were included. Transient was defined by a ≥ 1 cm between lower sphincter crural diaphragm SLR. compared motor patterns parameters with normal, transiently abnormal consistently morphology SLR.Of 85 (56.3% female,...
This study aims to evaluate the effects of acute codeine administration on primary and secondary esophageal peristalsis in patients with ineffective motility (IEM).
Esophagogastroduodenoscopy (EGD) is recommended in patients with typical gastroesophageal reflux disease (GERD) symptoms (heartburn, regurgitation, chest pain) the setting of proton pump inhibitor (PPI) nonresponse. EGD evaluates for erosive disease, assesses antireflux barrier integrity, excludes non-GERD conditions, and, absence findings, followed by testing.
Gastroesophageal reflux disease (GERD) exhibits a global prevalence ranging from 8% to 33%.1 Esophagogastroduodenoscopy serves as crucial diagnostic tool for providing objective evidence of GERD, such erosive esophagitis and Barrett's esophagus, excluding other potential causes. It is the preferred initial modality GERD surveillance mandated by national health insurance policy in Taiwan.2 diagnosis typically established through synthesis clinical, endoscopic, physiological criteria, recently...
INTRODUCTION: The COuGH RefluX score has been validated to predict likelihood of gastroesophageal reflux disease (GERD) in patients with laryngopharyngeal symptoms (LPS) using parameters cough, overweight, globus, hiatal hernia, regurgitation, and male sex. aim this study was assess the real-world value predicting proton-pump inhibitor (PPI) response LPS. METHODS: Patients LPS for > 3 months were prospectively enrolled assessed Reflux Symptom Index 24-hour impedance-pH monitoring. Based...