A5033063830- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Esophageal and GI Pathology
- Dysphagia Assessment and Management
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Mechanical Circulatory Support Devices
- Pleural and Pulmonary Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- Gallbladder and Bile Duct Disorders
- Lung Cancer Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Pancreatic and Hepatic Oncology Research
- Tracheal and airway disorders
- Respiratory and Cough-Related Research
- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Vascular anomalies and interventions
- Celiac Disease Research and Management
- Motor Control and Adaptation
- Carbon Dioxide Capture Technologies
- Biliary and Gastrointestinal Fistulas
Washington University in St. Louis
2013-2025
Northwestern University
2023
Medtronic (United States)
2019
Diversitech (United States)
2019
San Francisco VA Medical Center
2012
University of California, San Francisco
2012
James Cook University Hospital
2006
Glenfield Hospital
2001-2002
Abstract Background Distal contractile integral (DCI) and esophagogastric junction (EGJ‐CI) are high‐resolution manometry (HRM) software metrics assessing esophageal motor function in gastroesophageal reflux disease (GERD). Methods Patients undergoing HRM ambulatory pH monitoring off antisecretory therapy prospectively completed symptom questionnaires burden a global score (GSS) at baseline after GERD therapy. DCI<450 mm Hg/cm/s ≥5 swallows diagnosed ineffective motility (IEM);...
Abstract Background Association between proportions of hypomotile swallows on esophageal high‐resolution manometry (HRM) and reflux burden remains incompletely understood. We investigated relationships hypomotility, acid exposure time (AET), mean nocturnal baseline impedance (MNBI) ambulatory monitoring. Methods Clinical data, HRM, pH‐impedance studies (performed off suppression) from patients with persisting symptoms were reviewed five international centers. AET (abnormal > 6%) MNBI <...
Background: High-resolution manometry (HRM) allows characterization of esophagogastric junction (EGJ) morphology and identification hiatus hernia using novel software tools. Aim: The main purpose this study was to determine the impact HRM-based EGJ lower esophageal sphincter (LES) metrics in predicting abnormal reflux burden. Methods: Total, upright, supine acid exposure times (AETs) were extracted from ambulatory monitoring performed off therapy 482 patients (54.2±0.6 y, 63.3% female...
Abstract Background Mean nocturnal baseline impedance (MNBI) augments the diagnostic yield of multichannel intraluminal impedance‐pH (MII‐pH) monitoring. While acid exposure time (AET) correlates with MNBI, it remains unclear whether esophageal motility affects MNBI values. The present study was aimed at evaluating respective roles motor function and AET on MNBI. Methods High‐resolution manometry (HRM) studies ambulatory 24‐hour MII‐pH monitoring tracings were retrospectively analyzed from...
Stress is a known trigger for flares of inflammatory bowel disease (IBD) and irritable syndrome (IBS); however, this process not well understood. Here, we find that restraint stress in mice leads to signs diarrhea, fecal dysbiosis, barrier defect via the opening goblet-cell associated passages. Notably, increases host immunity gut bacteria as assessed by immunoglobulin A (IgA)-bound bacteria. Stress-induced microbial changes are necessary sufficient elicit these effects. Moreover, similar...
We explored if a score derived from parameters esophageal testing could increase confidence in diagnosing conclusive gastroesophageal reflux disease and predicting outcome.
Background. Previous reports describe false-positive urine immunoassay screens for phencyclidine (PCP) associated with use of tramadol, dextromethorphan, or diphenhydramine. The likelihood these false positives is unknown. Objective. We sought to find the relative frequency PCP medications and look any other similar associations. Methods. In an IRB-approved study, we retrospectively reviewed charts all ED encounters positive in our hospital from 2007 through 2011, inclusive. Urine samples...
Mentore Ribolsi, Edoardo Savarino, Benjamin Rogers, Arvind Rengarajan, Marco Della Coletta, Matteo Ghisa, Michele Cicala, and C Prakash Gyawali. J Neurogastroenterol Motil 2020;26:447-54. https://doi.org/10.5056/jnm19153
Abstract Background Postreflux swallow‐induced peristaltic wave (PSPW) on pH‐impedance monitoring and contraction vigor high‐resolution manometry (HRM) both assess esophageal response. We aimed to evaluate relationships between PSPW peristalsis HRM in the context of reflux disease this multicenter cohort study. Methods studies performed patients with persisting symptoms were reviewed from 6 centers (5 Europe 1 US). Total, upright supine acid exposure time (AET) evaluated studies; index...
When esophageal acid exposure time (AET) is physiologic, ROME IV stratifies functional disorders into heartburn (FH, with negative reflux-symptom association) and reflux hypersensitivity (RH, positive association), hypothesizes that FH/RH could overlap proven gastroesophageal disease (GERD). We compared conventional diagnosed off antisecretory therapy coexisting GERD.Adult patients underwent pH-impedance testing on (proven GERD) (unproven completed validated questionnaires defining symptoms...
Abstract Background Esophagogastric junction contractile integral (EGJ‐CI) and EGJ morphology are high‐resolution manometry (HRM) metrics that assess barrier function. Normative data standardized across world regions HRM manufacturers limited. Methods Our aim was to determine normative in a large international cohort of healthy volunteers undergoing (Medtronic, Laborie, Diversatek software) acquired from 16 countries four regions. EGJ‐CI calculated by the same two investigators using distal...
Aim: Current synthetic tubular conduits are inferior to nerve autograft for the repair of segmental peripheral injuries. We examined motor outcomes with use longitudinally aligned poly (L-lactide-co-caprolactone) nanofiber gap injury in a rat model. Methods: Ten-millimeter segments sciatic were resected 44 Lewis rats. The gaps either left unrepaired (n = 6), repaired 19), or conduit 19). After 12 weeks, conduction latency, compound muscle action potential amplitude, force and mass measured....
Abstract Background Straight leg raise (SLR) is a provocative maneuver that assesses esophagogastric junction (EGJ) barrier function during high‐resolution manometry (HRM). We evaluated the value of SLR in symptomatic reflux patients undergoing ambulatory monitoring. Methods Adult being for symptoms with esophageal physiologic testing off antisecretory therapy over 12 month period were studied. Demographics, clinical presentation, HRM studies, and monitoring studies analyzed. Intra‐abdominal...