A5078805296- Total Knee Arthroplasty Outcomes
- Knee injuries and reconstruction techniques
- Shoulder Injury and Treatment
- Osteoarthritis Treatment and Mechanisms
- Shoulder and Clavicle Injuries
- Orthopaedic implants and arthroplasty
- Tendon Structure and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Orthopedic Infections and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Spinal Cord Injury Research
- Sarcoma Diagnosis and Treatment
- Nerve Injury and Rehabilitation
- Cancer-related molecular mechanisms research
- Sports injuries and prevention
- Extracellular vesicles in disease
- Venous Thromboembolism Diagnosis and Management
- Lymphoma Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Bone Tissue Engineering Materials
- RNA Research and Splicing
- Bone Metabolism and Diseases
- Foot and Ankle Surgery
- Laser Applications in Dentistry and Medicine
- Graphene and Nanomaterials Applications
Qingdao University
2016-2025
Affiliated Hospital of Qingdao University
2016-2025
Qingdao Municipal Hospital
2023-2025
Third Hospital of Hebei Medical University
2023
Hebei Medical University
2023
Qingdao Center of Resource Chemistry and New Materials
2020
Qilu Hospital of Shandong University
2014
National Natural Science Foundation of China
2014
Peking University
2010
Abstract The role of microglia in spinal cord injury (SCI) remains ambiguous, partially due to the paucity efficient methods discriminate these resident with blood-derived monocytes/macrophages. Here, we used pharmacological treatments specifically eliminate and subsequently investigate response after SCI mice. We showed that treatment colony stimulating factor 1 receptor (CSF1R) inhibitor PLX3397 eliminated ~90% did not affect other cell types mouse cord. also induced a strong decrease...
It is imperative to develop and implement newer, more effective strategies address refractory diabetic wounds. As of now, there currently no optimal solution for these Hypoxic human umbilical vein endothelial cells (HUVECs)-derived exosomes have been postulated promote wound healing, however, its effect molecular mechanism need further study. In this study, we aimed investigate whether hypoxic enhance healing in diabetics. Based on our high-throughput sequencing, differentially expressed...
Background: Periprosthetic joint infection (PJI) is a catastrophic complication after total arthroplasty (TJA). Timely and accurate diagnosis important for the management of PJI. Currently, many biomarkers are available PJI, but which inflammatory biomarker combination has best diagnostic value not been reported. Materials Methods: We retrospectively analyzed 244 patients who underwent revision knee or hip in our institution. They were divided into two groups: 87 PJI group 157 aseptic...
Background: Most studies of allograft versus autograft for anterior cruciate ligament reconstruction have been bone–patellar tendon–bone; outcome reports evaluating with hamstring tendon are rare. Purpose: This study was undertaken to compare the clinical arthroscopic allograft. Study Design: Randomized controlled trial; Level evidence, 2. Methods: Between 2000 and 2004, 208 patients who met inclusion exclusion criteria were prospectively randomized into (n = 104) or groups. All allografts...
Preoperative prediction of soft tissue sarcoma (STS) grade is important for treatment decisions. Therefore, formulation an STS model strongly needed.To develop and test magnetic resonance imaging (MRI)-based radiomics nomogram predicting the (low-grade vs. high grade).Retrospective POPULATION: One hundred eighty patients with confirmed by pathologic results at two independent institutions were enrolled (training set, N = 109; external validation 71).Unenhanced T1-weighted (T1WI)...
Advancements in tissue engineering are crucial for successfully healing tendon-bone connections, especially situations like anterior cruciate ligament (ACL) restoration. This study presents a new and innovative three-dimensional scaffold, reinforced with nanofibers, that is specifically intended acellular tendon complexes. The scaffold consists of distinct layered arrangement comprising an core, middle layer polyurethane (PU)/ type I collagen yarn, outside poly (L-lactic acid)/bioactive...
Background Cartilage injury is the main pathological manifestation of osteoarthritis (OA). Healthy chondrocyte a prerequisite for cartilage regeneration and repair. Differences between healthy OA types role these play in progression are unclear. Method This study conducted single-cell RNA sequencing (scRNA-seq) on from normal distal femur knee (NC group) (OA cartilage, atlas was constructed, differences cell subtypes two groups were compared. Pseudo-time velocity analysis both performed to...
Knee ligaments are important structures that determine the locomotor function of knee. In this paper, we identified and analyzed cell types compositions from different parts healthy knee joint. By single-cell sequencing approximately 106,077 extracted cells, established a comprehensive cellular profile in other joints 15 subjects explored more critical heterogeneity fibroblasts. Three subpopulations fibroblasts may be associated with ligament anatomy were their differentiation relationships...
ABSTRACT Aims Spinal cord ischemia–reperfusion injury (SCIRI) is a disastrous complication that cannot be completely prevented in thoracoabdominal aneurysm surgery, leading to sensory and motor dysfunction even paraparesis, causing tremendous socioeconomic burden. Ferritinophagy form of autophagic ferroptosis, which contributor SCIRI. Hydrogen sulfide (H 2 S) has been reported neuroprotective various diseases. However, it remains unclear whether H S alleviates SCIRI‐induced neural death via...
Abstract Butyrate plays a crucial role in osteoarthritis (OA) development. However, the relationship between butyrate metabolism-related genes (BMRGs) and OA remains unclear. This study investigates potential correlation BMRGs using OA-related datasets (GSE55235, GSE12021 GSE143514). Differential expression analysis identified 38 differentially expressed (DE-BMRGs) from overlap of 782 (DEGs) 385 GSE55235. Enrichment indicated that these DE-BMRGs were tightly associated with cell...