A5103153603- Cancer-related molecular mechanisms research
- Total Knee Arthroplasty Outcomes
- Cardiac electrophysiology and arrhythmias
- Orthopaedic implants and arthroplasty
- Bone and Joint Diseases
- Ion channel regulation and function
- Cancer, Hypoxia, and Metabolism
- Orthopedic Infections and Treatments
- Cancer, Lipids, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Cancer Research and Treatments
- Ocular Surface and Contact Lens
- Knee injuries and reconstruction techniques
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Glaucoma and retinal disorders
- Protein Kinase Regulation and GTPase Signaling
- PI3K/AKT/mTOR signaling in cancer
- Corneal Surgery and Treatments
- Receptor Mechanisms and Signaling
- Autophagy in Disease and Therapy
- Hip disorders and treatments
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Circular RNAs in diseases
Stony Brook University
2013-2025
Chongqing University of Technology
2025
Affiliated Hospital of Qingdao University
2016-2025
Qingdao University
2016-2025
Northwest Normal University
2025
Yangpu Hospital of Tongji University
2018-2024
Syngenta (United States)
2021-2024
South China University of Technology
2024
Guangzhou Medical University
2024
Guangzhou First People's Hospital
2024
Doxorubicin, an anthracycline chemotherapeutic agent, is widely used in the treatment of many cancers. However, doxorubicin posts a great risk adverse cardiovascular events, which are thought to be caused by oxidative stress. We recently reported that ubiquitin E3 ligase TRIM21 interacts and ubiquitylates p62 negatively regulates p62-Keap1-Nrf2 antioxidant pathway. Therefore, we sought determine role cardiotoxicity induced damage.Using knockout mice, examined effects on two damage models:...
Background— Vasoactive intestinal peptide (VIP), a pulmonary vasodilator and inhibitor of vascular smooth muscle proliferation, has been reported absent in arteries from patients with idiopathic arterial hypertension (PAH). We have tested the hypothesis that targeted deletion VIP gene may lead to PAH remodeling. Methods Results— examined knockout (VIP −/− ) mice for evidence PAH, right ventricular (RV) hypertrophy, Relative wild-type control mice, showed moderate RV hypertension, hypertrophy...
Many drugs, including some commonly used medications, can cause abnormal heart rhythms and sudden death, as manifest by a prolonged QT interval in the electrocardiogram. Cardiac arrhythmias caused drug-induced long syndrome are thought to result mainly from reductions delayed rectifier potassium ion (K(+)) current I(Kr). Here, we report mechanism for prolongation that involves changes multiple currents decrease phosphoinositide 3-kinase (PI3K) signaling. Treatment of canine cardiac myocytes...
// Min Zheng 1, 2, * , Ya-ping Jiang Wei Chen 3, Kai-de Li 1 Xin Liu Shi-yu Gao Hao Feng Sha-sha Wang Jian Xiang-rui Ma Xiao Cen Ya-jie Tang 4 Yu Yun-feng Lin Ya-ling 5 Xin-hua Liang 6 State Key Laboratory of Oral Diseases West China Hospital Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic 2 Department Stomatology, Zhoushan Hospital, Zhoushan, Zhejiang 316000, 3 and Maxillofacial Surgery, Tianjin Stomatological 300041, Fermentation Engineering (Ministry...
Background: Periprosthetic joint infection (PJI) is a catastrophic complication after total arthroplasty (TJA). Timely and accurate diagnosis important for the management of PJI. Currently, many biomarkers are available PJI, but which inflammatory biomarker combination has best diagnostic value not been reported. Materials Methods: We retrospectively analyzed 244 patients who underwent revision knee or hip in our institution. They were divided into two groups: 87 PJI group 157 aseptic...
Diabetes is an independent risk factor for sudden cardiac death and ventricular arrhythmia complications of acute coronary syndrome. Prolongation the QT interval on electrocardiogram also a arrhythmias death, increased prevalence prolongation cardiovascular in diabetic patients. The pathophysiological mechanisms responsible this lethal complication are poorly understood. associated with reduction phosphoinositide 3-kinase (PI3K) signaling, which regulates action potential duration (APD)...
Background— Although multiple approaches have been used to create biological pacemakers in animal models, induced pluripotent stem cell–derived cardiomyocytes (iPSC-CMs) not investigated for this purpose. We now report pacemaker function of iPSC-CMs a canine model. Methods and Results— Embryoid bodies were derived from human keratinocytes, their action potential characteristics determined, gene expression profiles markers differentiation identified. Atrioventricular blocked dogs...
Bone defects are primarily the result of high-energy trauma, pathological fractures, bone tumor resection, or infection debridement. The treatment remains a huge clinical challenge. current options for include traction, autologous/allogeneic transplantation, gene therapy, and tissue engineering amongst others. With recent developments in field, composite scaffolds prepared using techniques to repair used more often. Among various scaffolds, hydrogel exhibits advantages good biocompatibility,...
Efficient genotype-independent transformation and genome editing are highly desirable for plant biotechnology research product development efforts. We have developed a novel approach to enable fast, high-throughput, genotype-flexible Agrobacterium-mediated using the important crop soybean as test system. This new method is called GiFT (genotype-independent fast transformation) involves only few simple steps. The uses germinated seeds explants, DNA delivery achieved through Agrobacterium...
Phosphoinositide 3-kinase (PI3K) p110alpha plays a key role in insulin action and tumorigenesis. Myocyte contraction is initiated by an inward Ca(2+) current (I(Ca,L)) through the voltage-dependent L-type channel (LTCC). The aim of this study was to evaluate whether also controls cardiac contractility regulating LTCC.Genetic ablation (also known as Pik3ca), but not p110beta Pik3cb), myocytes adult mice reduced I(Ca,L) blocked signaling heart. p110alpha-null had number LTCCs on cell surface...
Contraction of cardiac myocytes is initiated by Ca(2+) entry through the voltage-dependent L-type channel (LTCC). Previous studies have shown that phosphatidylinositol (PI) 3-kinase signaling modulates LTCC function. Because PI 3-kinases are key mediators insulin action, we investigated whether function affected in diabetic animals due to reduced signaling.We used whole-cell patch clamping and biochemical assays compare insulin-deficient mice heterozygous for Ins2(Akita) mutation versus...
A highly organized transverse tubule (T-tubule) network is necessary for efficient Ca(2+)-induced Ca(2+) release and synchronized contraction of ventricular myocytes. Increasing evidence suggests that T-tubule remodeling due to junctophilin-2 (JP-2) downregulation plays a critical role in the progression heart failure. However, mechanisms underlying JP-2 dysregulation remain incompletely understood.A mouse model reversible failure driven by conditional activation heterotrimeric G protein Gαq...
Adipose tissue is a highly insulin-responsive organ that contributes to metabolic regulation. Insulin resistance in the adipose affects systemic lipid and glucose homeostasis. Phosphoinositide 3-kinase (PI3K) mediates downstream insulin signaling tissue, but its physiological role vivo remains unclear. Using Cre recombinase driven by aP2 promoter, we created mice lack class 1A PI3K catalytic subunit p110α or p110β specifically white brown tissue. The loss of p110α, not p110β, resulted...
Abstract Asian soybean rust (ASR), caused by Phakopsora pachyrhizi , is a devastating disease that present in all major soybean-producing regions. The limited availability of resistant germplasm has resulted scarcity commercial cultivars are to the disease. To date, only Chinese landrace SX6907 demonstrated an immune response ASR. In this study, we isolation and characterization Rpp6907-7 Rpp6907-4 gene pair confer broad-spectrum resistance encode atypic nucleotide-binding leucine-rich...
In cultured cells, growth factor-induced phosphorylation of two translation modulators, p70 S6 kinase and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), is blocked by nanomolar concentrations the immunosuppressant rapamycin. Rapamycin also attenuates liver regeneration after partial hepatectomy, but it not known if this growth-suppressive effect due to dephosphorylation and/or 4E-BP1. We found that hepatectomy induced a transient increase in activity 4E-BP1 as compared with...
Loss-of-function mutations in SMN1 cause spinal muscular atrophy (SMA), a leading genetic of infant mortality. The related SMN2 gene expresses suboptimal levels functional SMN protein, due to splicing defect. Many SMA patients reach adulthood, and there is also adult-onset (type IV) SMA. There currently no animal model for SMA, the tissue-specific pathogenesis post-developmental deficiency remains elusive. Here, we use an antisense oligonucleotide (ASO) exacerbate mis-splicing....
Background Phosphoinositide 3-kinases (PI3Ks) regulate numerous physiological processes including some aspects of cardiac function. Although regulation contraction by individual PI3K isoforms has been studied, little is known about the consequences downregulating multiple PI3Ks concurrently. Methods and Results Genetic ablation both p110α p110β in myocytes throughout development or adult mice caused heart failure death. Ventricular from double knockout animals showed transverse tubule...
The emerging evidence showed that long noncoding RNAs (lncRNAs) are involved in cell growth and apoptosis as well cancer progression metastasis of malignant tumor, however, limited data available on the role lncRNAs human papillomavirus (HPV)-associated Head neck squamous carcinomas (HNSCC). Here, we demonstrated 23.98% 196 HNSCC cases Southwest China could be classified HPV16 infection. number MDSCs HPV-positive was significantly higher than normal control, indicating HPV infection may...
Cancer stem cells (CSCs) have gained much attention due to their roles in the invasion and metastasis of numerous kinds human cancers. Here, we showed that positive expression CD133, stemness marker, was positively associated with vasculogenic mimicry (VM) formation, local regional recurrence, distant poorer prognosis salivary adenoid cystic carcinoma (ACC) specimens. Compared CD133- ACC cells, CD133+ cancer stem-like had more migration capabilities, as well VM formation. The levels...